Many types of tumors harbor a mutation in the gene for the metabolic enzyme isocitrate dehydrogenase result-ing in the production of the oncometabolite d-2-hydroxy glutarate with a pleiotropic effect on the cell. The paper provides an overview of the latest knowledge of the me-chanism of carcinogenesis, of specific drugs suppressingd-2-hydroxy glutarate production and of the causes of resistance complicating treatment based on specific inhibi-tors of oncogenic forms of isocitate dehydrogenase.

• MeSH
• isocitrátdehydrogenasa * chemie   metabolismus   MeSH
• lidé MeSH
• mutace * MeSH
• nádorová transformace buněk * chemie   MeSH
• protinádorové látky terapeutické užití   MeSH
• Check Tag
• lidé MeSH