Cadmium (Cd) is a heavy metal that occurs in all areas of the environment, including the food chain. In the body, it causes oxidative stress by producing free radicals that are harmful to the cells. Grape seed extract (GSE) contains a wide range of biologically active components that help to neutralize the adverse effects of free radicals. In this study, the effects of GSE prepared form semi-resistant grapevine cultivar Cerason, which is rich in phenolics, on biochemical markers of brown rats exposed to the effects of cadmium were monitored. GSE increased the plasma antioxidant activity and, in the kidneys and the liver, Cd content was significantly lowered by GSE co-administration. Accordingly, the increase in creatinine content and alanine aminotransferase activity and the decrease of catalase and superoxide dismutase activities caused by cadmium were slowed down by GSE co-administration. The results of this work reveal that grape seed extract offers a protective effect against the intake of heavy metals into the organism.
- MeSH
- Alanine Transaminase blood MeSH
- Antioxidants analysis MeSH
- Aspartate Aminotransferases blood MeSH
- Biomarkers metabolism MeSH
- Grape Seed Extract pharmacology MeSH
- Phytochemicals analysis MeSH
- Liver drug effects enzymology metabolism MeSH
- Cadmium blood MeSH
- Catalase metabolism MeSH
- Creatinine blood MeSH
- Kidney drug effects metabolism MeSH
- Metallothionein metabolism MeSH
- Urea blood MeSH
- Rats, Wistar MeSH
- Seeds chemistry MeSH
- Superoxide Dismutase metabolism MeSH
- Health * MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
This review is focused on the study of the effects of grape seed and skin extract (GSSE) on human health. GSSE contains high concentrations of important polyphenolic substances with high biological activity. This review is a summary of studies that investigate the effects of GSSE on diabetes mellitus, cardiovascular disease and cancer, its neuroprotective effect, and its effects on the gastrointestinal tract and other health complications related to these diseases. The results of the studies confirm that the anti-inflammatory, antiapoptotic, and pro-proliferative effects of "Vitis vinifera L." seed extract reduce the level of oxidative stress and improve the overall lipid metabolism.
- MeSH
- Biomarkers metabolism MeSH
- Grape Seed Extract pharmacology MeSH
- Humans MeSH
- Lipids blood MeSH
- Disease MeSH
- Neuroprotective Agents pharmacology MeSH
- Health * MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
