The aim of this study is to evaluate the usefulness of heart rate recovery (HRRec) for assessing risk of death in heart failure (HF) patients. Echocardiographic and clinical exercise data were analyzed retrospectively on 712 HF patients (EF < or = 45%). HRRec was calculated as peak exercise heart rate - heart rate at 1 min of active recovery. Patients were followed for all-cause mortality (5.9 +/- 3.3 years follow-up). Groups were identified according to HRRec: group-1 (HRR < or = 4 bpm), group-2 (5 < or = HRR < or = 9 bpm), and group-3 (HRR > or = 10). Kaplan-Meier analysis estimated survival of 91, 64, and 43% (group-1); 94, 76, and 63% (group-2); and 92, 82, and 70% (group-3) at 1, 5, and 10 years, respectively. Ranked HRRec independently predicted mortality after adjusting for age, gender, NYHA class, LVEF and BMI, but was not independent of exercise time, peak V(O)(2) and V(E)/V(CO)(2) at nadir. HRRec is a useful prognostic marker in patients with HF, particularly when gas exchange measures are not available.

• MeSH
• elektrokardiografie MeSH
• lidé středního věku MeSH
• lidé MeSH
• následné studie MeSH
• obnova funkce MeSH
• prognóza MeSH
• retrospektivní studie MeSH
• senioři MeSH
• spotřeba kyslíku fyziologie   MeSH
• srdeční frekvence fyziologie   MeSH
• srdeční selhání mortalita   patofyziologie   MeSH
• zátěžový test MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH

PURPOSE: To assess the diagnostic performance of the skinfold (SKF) method to detect obesity in patients enrolled in an outpatient cardiac rehabilitation (CR) program. METHODS: This study involves outpatients attending a phase II CR program who underwent air displacement plethysmography (ADP) to assess body composition. We measured body fat percentage (BF%), using a 3-site SKF method calculated through the Jackson-Pollock equation utilizing a Harpenden caliper. Air displacement plethysmography calculated BF% using a bicompartmental model, deriving the body composition after the direct calculation of body density (BD), using the Siri equation [(BF% = 495/BD) - 450]. We calculated the diagnostic performance of SKF to detect obesity, utilizing a BF% cutoff of ≥35% for women and ≥25% for men determined by SKF and ADP to define obesity. RESULTS: Our sample (n = 310) was 80% men, 60.2 ± 11 years of age, had a mean weight of 89.88 ± 17.96 kg, height 173.38 ± 8.68 cm, body mass index (BMI) 29.78 ± 5.01 kg/m, waist circumference 100.55 ± 14.38 cm, and waist-to-hip ratio of 0.96 ± 0.09. The evaluation of the diagnostic performance of SKF to detect obesity showed a sensitivity of 57%, specificity of 93%, a positive predictive value of 97%, and a negative predictive value of 33%. These values were not different from the diagnostic performance of BMI to detect obesity as defined by BF%. SKF and BMI misclassified 43% and 49% of obese patients as nonobese, respectively. CONCLUSION: Our findings underscore the limitation of using SKF to assess body fatness in the CR setting.

• MeSH
• lidé středního věku MeSH
• lidé MeSH
• nemoci srdce komplikace   rehabilitace   MeSH
• obezita komplikace   diagnóza   MeSH
• odchylka pozorovatele MeSH
• pletysmografie metody   MeSH
• průřezové studie MeSH
• retrospektivní studie MeSH
• senioři MeSH
• senzitivita a specificita MeSH
• tloušťka kožní řasy * MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

BACKGROUND: Mechanisms of decreased exercise capacity in patients with hypertrophic cardiomyopathy (HCM) are not well understood. Sleep-disordered breathing (SDB) is a highly prevalent but treatable disorder in patients with HCM. The role of comorbid SDB in the attenuated exercise capacity in HCM has not been studied previously. METHODS: Overnight oximetry, cardiopulmonary exercise testing, and echocardiographic studies were performed in consecutive patients with HCM seen at the Mayo Clinic. SDB was considered present if the oxygen desaturation index (number of >= 4% desaturations/h) was >= 10. Peak oxygen consumption (VO2 peak) (the most reproducible and prognostic measure of cardiovascular fitness) was then correlated with the presence and severity of SDB. RESULTS: A total of 198 patients with HCM were studied (age, 53 +/- 16 years; 122 men), of whom 32% met the criteria for the SDB diagnosis. Patients with SDB had decreased VO2 peak compared with those without SDB (16 mL O2/kg/min vs 21 mL O2/kg/min, P < .001). SDB remained significantly associated with VO2 peak after accounting for confounding clinical variables (P < .001) including age, sex, BMI, atrial fibrillation, and coronary artery disease. CONCLUSIONS: In patients with HCM, the presence of SDB is associated with decreased VO2 peak. SDB may represent an important and potentially modifiable contributor to impaired exercise tolerance in this unique population.

• MeSH
• dospělí MeSH
• hypertrofická kardiomyopatie * epidemiologie   patofyziologie   MeSH
• komorbidita MeSH
• lidé středního věku MeSH
• lidé MeSH
• oxymetrie MeSH
• prevalence MeSH
• průřezové studie MeSH
• senioři MeSH
• spánková apnoe centrální * MeSH
• spotřeba kyslíku fyziologie   MeSH
• srdeční frekvence fyziologie   MeSH
• stupeň závažnosti nemoci MeSH
• tepový objem fyziologie   MeSH
• tolerance zátěže * fyziologie   MeSH
• zátěžový test MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH