The effects of therapeutic or preventive-therapeutic administration of water-soluble echinochrome analog U-441 on arrhythmia severity assessed by a set of myocardial spatio-temporal depolarization and repolarization parameters were examined on the model of acute myocardial ischemia in cats. Coronary occlusion increased activation time and decreased repolarization time in the ischemic zone; in addition, it increased both global and borderline (local) dispersions of repolarization. The linear regression model showed that only activation time values measured at the initial state and at termination of occlusion were associated with total arrhythmia score during ischemia (regression coefficient β=0.338, 95%CI=0.074-0.602, p=0.015 and β=0.720, 95%CI=0.323-1.117, p=0.001, respectively). The study revealed no association between administration of echinochrome analog U-441 and arrhythmia severity.

• MeSH
• antiarytmika izolace a purifikace   farmakologie   MeSH
• elektrokardiografie MeSH
• ischemická choroba srdeční farmakoterapie   patofyziologie   MeSH
• ježovky chemie   MeSH
• kočky MeSH
• koronární okluze chirurgie   MeSH
• modely nemocí na zvířatech MeSH
• myokard patologie   MeSH
• naftochinony izolace a purifikace   farmakologie   MeSH
• převodní systém srdeční účinky léků   patofyziologie   MeSH
• rozpustnost MeSH
• srdeční arytmie farmakoterapie   patofyziologie   MeSH
• stupeň závažnosti nemoci MeSH
• terapie neúspěšná MeSH
• voda chemie   MeSH
• zvířata MeSH
• Check Tag
• kočky MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH