Biocides are very effective against huge spectrum of microorganisms and are used in wide range. Recent research pointed out on fact that there could be connection between use of biocides and development of antibiotic resistance. This paper assesses long-term effect of common biocides in subinhibitory concentrations on the development of antibiotic resistance in Enterococcus faecalis. We have studied effect of three common biocides – NaClO, ClO2 and H2O2/Ag. Obtained data showed, that all biocides decreased susceptibility of E. faecalis to ampicillin. In case of H2O2/Ag also gentamicin resistance has developed after long-term treatment. On the other hand, this biocide has caused loss of vancomycin resistance in E. faecalis. This suggests very important fact; however vancomycin resistant enterococci are according to WHO classified as pathogens with high priroty.

• Klíčová slova
• subinhibiční koncentrace, křížová rezistence,
• MeSH
• ampicilin MeSH
• antibakteriální látky klasifikace   MeSH
• bakteriální léková rezistence * účinky léků   MeSH
• ciprofloxacin MeSH
• dezinficiencia * klasifikace   MeSH
• Enterococcus faecalis účinky léků   MeSH
• gentamiciny MeSH
• mikrobiální testy citlivosti MeSH
• vankomycin MeSH
• výzkum MeSH