Biological role of reactive oxygen species in skin*
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[1st ed.] XIV, 282 s. : tab., grafy ; 21 cm
- MeSH
- fagocyty fyziologie MeSH
- kůže patofyziologie MeSH
- kyslík metabolismus škodlivé účinky MeSH
- světlo škodlivé účinky MeSH
- volné radikály metabolismus MeSH
- Publikační typ
- kongresy MeSH
- sborníky MeSH
- Konspekt
- Patologie. Klinická medicína
- NLK Obory
- dermatovenerologie
- biochemie
- dermatovenerologie
Nrf2 and NF-κB transcription factors act in wound healing via their anti-inflammatory and anti-oxidant effects or through the immune response. Studying this process is a matter of some importance given the high cost of wound treatment. A major contribution in this regard is being made by models that enable investigation of the involvement of multiple factors in wound healing and testing new curative substances. This literature review was carried out via searches in the PubMed and Web of Science databases up to 2016. It covers skin wound healing, available models for its study (part I), the role of Nrf2 and NF-κB, substances that influence them and whether they can be used as markers (part II). Was found that in vitro assays are used for their availability but a holistic view must be established in vivo. In silico approaches are facilitating assessment of a vast amount of research data. Nfr2 and NF-κB play a crucial and reciprocal role in wound healing. Nrf2 controls repair-associated inflammation and protects against excessive accumulation of ROS while Nf-κB activates the innate immune reaction, proliferation and migration of cells, modulates expression of matrix metalloproteinases, secretion and stability of cytokines and growth factors for wound healing.
- MeSH
- biologické modely MeSH
- biotest metody MeSH
- faktor 2 související s NF-E2 antagonisté a inhibitory fyziologie MeSH
- hojení ran imunologie fyziologie MeSH
- kůže * MeSH
- lidé MeSH
- NF-kappa B antagonisté a inhibitory fyziologie MeSH
- oxidační stres fyziologie MeSH
- pohyb buněk imunologie fyziologie MeSH
- přirozená imunita fyziologie MeSH
- proliferace buněk fyziologie MeSH
- reaktivní formy kyslíku metabolismus MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
... Extracellular Messengers and Channel Regulation, 22 Second Messengers, 22 Cellular Metabolism, 25 Role ... ... Oxygen Species—Oxidative Stress, 59 Chemical Injury, 62 -- Unintentional and Intentional Injuries, 70 ... ... Role and Kathryn L. ... ... Huether Structure and Function of the Skin, 1616 Layers of the Skin, 1616 Subcutaneous Layer, 1618 AGING ... ... and Skin Integrity, 1619 Tests of Skin Function, 1619 Clinical Manifestations of Skin Dysfunction, 1619 ...
7th ed. xxvi, 1810 s. : il. (převážně barev.) ; 29 cm
- MeSH
- biomedicínský výzkum MeSH
- dítě MeSH
- dospělí MeSH
- fyziologie MeSH
- klinické lékařství MeSH
- patologie MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- Konspekt
- Experimentální medicína
- Učební osnovy. Vyučovací předměty. Učebnice
- NLK Obory
- patologie
- fyziologie
- NLK Publikační typ
- učebnice vysokých škol
- kolektivní monografie
... Specialize 23 -- Choosing the Right Experimental Organism for the Job 25 -- The Most Successful Biological ... ... Dissociation Constants of Binding Reactions Reflect the Affinity of Interacting Molecules 50 -- Biological ... ... Biochemical Energetics 54 -- Several Forms of Energy Are Important in -- Biological Systems 54 -- Cells ... ... Proteomics 105 -- Proteomics Is the Study of All or a Large Subset of Proteins in a Biological System ... ... Oxygen Species During Photoelectron Transport 521 -- Cyclic Electron Flow Through PSI Generates a -- ...
6th ed. xxxvii, 1150 s. : il., tab. ; 29 cm
- MeSH
- biologie buňky MeSH
- molekulární biologie MeSH
- Publikační typ
- monografie MeSH
- Konspekt
- Biochemie. Molekulární biologie. Biofyzika
- NLK Obory
- biologie
- cytologie, klinická cytologie
