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Fischer, Natalie* Dotaz Zobrazit nápovědu

2 záznamů v Medvik

Článek

Shortening the washout to 4 weeks when switching from natalizumab to fingolimod and risk of disease reactivation in multiple sclerosis

BACKGROUND: There is limited evidence about the optimal length of washout when switching from natalizumab ...

Naegelin, Y
Autor Naegelin, Y Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, Biomedicine and Biomedical Engineering, University Hospital and University of Basel, Petersgraben 4, Basel 4031, Switzerland. Electronic address: Yvonne.naegelin@usb.ch
Rasenack, M
Autor Rasenack, M Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, Biomedicine and Biomedical Engineering, University Hospital and University of Basel, Petersgraben 4, Basel 4031, Switzerland
Andelova, M
Autor Andelova, M Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, Biomedicine and Biomedical Engineering, University Hospital and University of Basel, Petersgraben 4, Basel 4031, Switzerland Medical Image Analysis Center, University Hospital Basel, Marktgasse 8, Basel 4051, Switzerland Department of Neurology, First Faculty of Medicine, Charles University and General Hospital Prague, Ovocný trh 560/5, Prague 1 116 36, Czech Republic
Von Felten, S
Autor Von Felten, S Clinical Trial Unit, Department of Clinical Research, University Hospital Basel, Schanzenstrasse 55, Basel 4056, Switzerland
Fischer-Barnicol, B
Autor Fischer-Barnicol, B Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, Biomedicine and Biomedical Engineering, University Hospital and University of Basel, Petersgraben 4, Basel 4031, Switzerland
Amann, M
Autor Amann, M Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, Biomedicine and Biomedical Engineering, University Hospital and University of Basel, Petersgraben 4, Basel 4031, Switzerland Medical Image Analysis Center, University Hospital Basel, Marktgasse 8, Basel 4051, Switzerland Department of Radiology and Nuclear Medicine, University Hospital Basel, Petersgraben 4, Basel 4031, Switzerland
Mehling, M
Autor Mehling, M Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, Biomedicine and Biomedical Engineering, University Hospital and University of Basel, Petersgraben 4, Basel 4031, Switzerland
Kappos, L
Autor Kappos, L Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, Biomedicine and Biomedical Engineering, University Hospital and University of Basel, Petersgraben 4, Basel 4031, Switzerland
Sprenger, T
Autor Sprenger, T Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, Biomedicine and Biomedical Engineering, University Hospital and University of Basel, Petersgraben 4, Basel 4031, Switzerland Medical Image Analysis Center, University Hospital Basel, Marktgasse 8, Basel 4051, Switzerland Department of Neurology, DKD HELIOS Klinik Wiesbaden, Aukammallee 33, 65191 Wiesbaden, Germany
Derfuss, T
Autor Derfuss, T Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, Biomedicine and Biomedical Engineering, University Hospital and University of Basel, Petersgraben 4, Basel 4031, Switzerland

Multiple sclerosis and related disorders. 2018 ; 25 (-) : 14-20. [pub] 20180706

Mult Scler Relat Disord
ISSN 2211-0356
Medvik
Zdroj

BACKGROUND: There is limited evidence about the optimal length of washout when switching from natalizumab to fingolimod. OBJECTIVE: To study if a washout period of 4 weeks is associated with less disease activity compared to 8 weeks. METHODS: 25 patients with Relapsing Remitting Multiple Sclerosis were included in an open label, prospective study with a follow-up of 108 weeks. The primary endpoint (PE) was defined as "time to first relapse or MRI disease activity up to week 56". In addition, a recurrent event analysis (REA) was performed up to week 108. RESULTS: The PE was not met (HR 0.67, 95% CI [0.22,1.97], p = 0.462). Number of relapses before stopping natalizumab was positively associated with the hazard of relapse (HR 3.91, p = 0.0117, 95% CI [1.36, 11.28]). The REA showed a reduction of the hazard to develop a relapse by 77% (HR 0.23, 95% CI [0.08, 0.69], p = 0.00854) in favor of the cohort with 4 weeks washout. CONCLUSIONS: Our study suggests that switching from natalizumab to fingolimod with a shorter washout of 4 weeks might reduce the risk of disease reactivation after switching.

Článek

A large multi-country outbreak of monkeypox across 41 countries in the WHO European Region, 7 March to 23 August 2022

Euro surveillance. 2022 ; 27 (36) : . [pub] -

Euro Surveill
ISSN 1560-7917
Medvik
Zdroj

Following the report of a non-travel-associated cluster of monkeypox cases by the United Kingdom in May 2022, 41 countries across the WHO European Region have reported 21,098 cases and two deaths by 23 August 2022. Nowcasting suggests a plateauing in case notifications. Most cases (97%) are MSM, with atypical rash-illness presentation. Spread is mainly through close contact during sexual activities. Few cases are reported among women and children. Targeted interventions of at-risk groups are needed to stop further transmission.

MeSH
dítě MeSH
epidemický výskyt choroby MeSH
exantém * MeSH
lidé MeSH
opičí neštovice * diagnóza epidemiologie MeSH
Světová zdravotnická organizace MeSH
virus opičích neštovic MeSH
zvířata MeSH
Check Tag
dítě MeSH
lidé MeSH
ženské pohlaví MeSH
zvířata MeSH
Publikační typ
časopisecké články MeSH

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Fischer, Natalie* Dotaz Zobrazit nápovědu

Fischer, Natalie* Dotaz Zobrazit nápovědu

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