Indian perspective of human nature and personality are often viewed through a trigunas perspective-Sattva, Rajas and Tamas. The current study investigated the triadic gunas and well-being dimensions across 3 nations India (n=493; 194 males and 299 females; mean age=21.73 years, SD=3.23), USA (n=302; 80 males and 222 females; mean age=22.90years, SD=2.78) and Czech Republic (n=353; 67 males and 286 females; mean age=22.29years, SD=2.29) with a total of 1148 participants. Triguna Personality (Vedic Personality inventory) and well- being dimensions measured by Mental Health Continuum- Short Form, Flourishing scale and the Scale of Positive and Negative Experiences (MHC-SF, FS and SPANE) differed across countries. Triguna were correlated with MHC-SF and its clusters, FS and SPANE. Regression analysis revealed that Trigunas accounted significantly for well-being dimensions, for instance, Sattva accounted for 48% variance in Czechs, 56% in Indians and 55% in Americans, Rajas accounted for 21% variance in Czechs, 08% in Indians and 54% in Americans and Tamas accounted for 50% variance in Czechs, 20% in Indians and 64% in Americans. The results reinforce that trigunas personality significantly predict well-being dimensions.

• MeSH
• dospělí MeSH
• lidé MeSH
• mladý dospělý MeSH
• osobní uspokojení * MeSH
• osobnost fyziologie   MeSH
• srovnání kultur * MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Česká republika etnologie   MeSH
• Indie etnologie   MeSH
• Spojené státy americké etnologie   MeSH

The single-stranded RNA genome of SARS-CoV-2 is highly structured. Numerous helical stem-loop structures interrupted by mismatch motifs are present in the functionally important 5'- and 3'-UTRs. These mismatches modulate local helical geometries and feature unusual arrays of hydrogen bonding donor and acceptor groups. However, their conformational and dynamical properties cannot be directly inferred from chemical probing and are difficult to predict theoretically. A mismatch motif (SL1-motif) consisting of three consecutive U•U base pairs is located in stem-loop 1 of the 3'-UTR. We combined NMR-spectroscopy and MD-simulations to investigate its structure and dynamics. All three U•U base pairs feature two direct hydrogen bonds and are as stable as Watson-Crick A:U base pairs. Plasmodium falciparum 25S rRNA contains a triple U•U mismatch motif (Pf-motif) differing from SL1-motif only with respect to the orientation of the two closing base pairs. Interestingly, while the geometry of the outer two U•U mismatches was identical in both motifs the preferred orientation of the central U•U mismatch was different. MD simulations and potassium ion titrations revealed that the potassium ion-binding mode to the major groove is connected to the different preferred geometries of the central base pair in the two motifs.

• MeSH
• 3' nepřekládaná oblast * MeSH
• chybné párování bází * MeSH
• COVID-19 virologie   MeSH
• genom virový MeSH
• konformace nukleové kyseliny MeSH
• lidé MeSH
• nukleotidové motivy * MeSH
• párování bází MeSH
• Plasmodium falciparum genetika   MeSH
• RNA virová * chemie   genetika   MeSH
• SARS-CoV-2 * genetika   chemie   MeSH
• simulace molekulární dynamiky MeSH
• vodíková vazba MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH