repair and defence function
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... SKIN STRUCTURE AND FUNCTION 10 -- 3.1 Functions of the skin 10 -- 3.1.1 Barrier function 10 -- 3.1.2 ... ... Temperature control 11 -- 3.1.3 Defence and repair 11 -- 3.2 Skin structure 12 -- 3.2.1 Epidermis 12 ...
Environmental health criteria, ISSN 0250-863X 235
xix, 197 s. : il., tab. ; 21 cm
- Konspekt
- Veřejné zdraví a hygiena
- NLK Obory
- dermatovenerologie
- environmentální vědy
- NLK Publikační typ
- publikace WHO
Terminally-differentiated cells cease to proliferate and acquire specific sets of expressed genes and functions distinguishing them from less differentiated and cancer cells. Mature granulocytes show lobular structure of cell nuclei with highly condensed chromatin in which HP1 proteins are replaced by MNEI. These structural features of chromatin correspond to low level of gene expression and the loss of some important functions as DNA damage repair, shown in this work and, on the other hand, acquisition of a new specific function consisting in the release of chromatin extracellular traps in response to infection by pathogenic microbes. Granulocytic differentiation is incomplete in myeloid leukemia and is manifested by persistence of lower levels of HP1γ and HP1β isoforms. This immaturity is accompanied by acquisition of DDR capacity allowing to these incompletely differentiated multi-lobed neutrophils of AML patients to respond to induction of DSB by γ-irradiation. Immature granulocytes persist frequently in blood of treated AML patients in remission. These granulocytes contrary to mature ones do not release chromatin for NETs after activation with phorbol myristate-12 acetate-13 and do not exert the neutrophil function in immune defence. We suggest therefore the detection of HP1 expression in granulocytes of AML patients as a very sensitive indicator of their maturation and functionality after the treatment. Our results show that the changes in chromatin structure underlie a major transition in functioning of the genome in immature granulocytes. They show further that leukemia stem cells can differentiate ex vivo to mature granulocytes despite carrying the translocation BCR/ABL.
- MeSH
- akutní myeloidní leukemie genetika metabolismus patologie MeSH
- buněčná diferenciace * MeSH
- chromatin genetika MeSH
- chromozomální proteiny, nehistonové genetika metabolismus MeSH
- fluorescenční protilátková technika MeSH
- granulocyty metabolismus patologie MeSH
- hematopoetické kmenové buňky metabolismus patologie MeSH
- kultivované buňky MeSH
- kvantitativní polymerázová řetězová reakce MeSH
- lidé MeSH
- messenger RNA genetika MeSH
- neutrofily patologie MeSH
- polymerázová řetězová reakce s reverzní transkripcí MeSH
- poškození DNA * MeSH
- proliferace buněk MeSH
- tetradekanoylforbolacetát MeSH
- western blotting MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
sv.
- MeSH
- nemoci dýchací soustavy MeSH
- Publikační typ
- periodika MeSH
- Konspekt
- Patologie. Klinická medicína
- NLK Obory
- pneumologie a ftizeologie
... Structure and Function of Mesothelial Cells 1 -- Introduction 1 -- Structure of Mesothelial Cells 1 - ... ... - Mesothelial Cell Functions 3 -- Slippery Protective Layer 3 -- Inflammation and Immune Response 4 - ... ... - Tissue Repair 6 -- Fibrin Regulation 6 -- Role of Mesothelial Cells in Tumour Dissemination 7 -- Cell ... ... Immunotherapy of Peritoneal Carcinomatosis 483 -- Immunological Defence Mechanisms of the Peritoneal ...
Cancer treatment and research ; 134
xxxi, 533 stran : ilustrováno ; 25 cm
- MeSH
- klinické lékařství MeSH
- peritoneální nádory terapie MeSH
- týmová péče o pacienty MeSH
- Publikační typ
- monografie MeSH
- Konspekt
- Patologie. Klinická medicína
- NLK Obory
- vnitřní lékařství
- onkologie
... . : The measuring of individual DNA repair capacity using comet assay 154 -- BIORHYTMS lt5D -- LeGture ... ... spindle of the ciliate nucleus 172 -- Sedlárova M., Lebeda A., Binarová P.: Plant cytoskeleton in defence ... ... apterus 200 h N Siboni L., De la Fuente M.: A Single acupuncture session Guayerbas • | jm’mune cell functions ... ... Effects of neuropeptide Y -- Puerto /w., / jne on severa| macrophage and lymphocyte functions 204 -- ...
242 s. ; 22 cm
- MeSH
- entomologie MeSH
- fyziologie buňky MeSH
- hematologie MeSH
- kompartmentace buňky MeSH
- nádorové procesy MeSH
- Publikační typ
- kongresy MeSH
- Konspekt
- Biologické vědy
- NLK Obory
- biologie
- biologie
- onkologie
