- Keywords
- OUABAIN-STROFANTÍN G,
- MeSH
- Heparin MeSH
- Drug Evaluation pharmacokinetics MeSH
- Carbamates pharmacokinetics MeSH
- Guinea Pigs MeSH
- Ouabain adverse effects MeSH
- Propafenone analogs & derivatives pharmacokinetics MeSH
- Arrhythmias, Cardiac drug therapy MeSH
- In Vitro Techniques MeSH
- Animals MeSH
- Check Tag
- Guinea Pigs MeSH
- Animals MeSH
- MeSH
- Immunochemistry methods MeSH
- Pesticides analysis MeSH
- Publication type
- Review MeSH
The work deals with the design, synthesis and biolog-icalactivityofnewcarbamatecholinesteraseinhibitors.Itis focused on selected syntheses of new carbamate deriva-tives, which were tested for their anticholinesterase activi-ty against acetylcholinesterase as well as butyrylcholines-terase. Despite various theories in the pathogenesis of Alz-heimer's disease, drugs that can inhibit these two enzymes still represent the major approach to the treatment of this neurodegenerative disease. Many of the newly synthesized compounds have unique chemical structure. Recently, the approach to the synthesis of new cholinesterase inhibitors has focused on the preparation of potential drugs, contain-ing in their chemical structure fragments of already known drugs, commonly used in the pharmacotherapy of Alzhei-mer's disease, but also other diseases. The aim of prepar-ing these compounds is to affect several biological systems simultaneously. These multipotent compounds have been termed "multi-target-directed ligands"; the molecules of drugs used to treat Alzheimer's disease always contain a pharmacophore acting as a cholinesterase inhibitor, which represents the mainstay of therapy
- MeSH
- Acetylcholinesterase MeSH
- Alzheimer Disease diagnosis drug therapy pathology MeSH
- Butyrylcholinesterase MeSH
- Cholinesterase Inhibitors * chemistry pharmacology therapeutic use MeSH
- Carbamates chemistry therapeutic use MeSH
- Humans MeSH
- Rivastigmine analogs & derivatives therapeutic use MeSH
- Drug Development methods MeSH
- Check Tag
- Humans MeSH
Autorka uvádí přehled používaných antidot pro intoxikaci organofosforovými a karbamátovými insekticidy. Při otravě organo- fosfáty lze použít injekční přípravky: Atropin + Toxogonin + Diazepam, při intoxikaci karbamáty se Toxogonin nepodává. Jsou uvedeny kazuistiky otrav.
The author presents a survey of antidotes use in cases of poisoning with organophosphate and carbamate insecticides. In cases of organophosphate poisoning it is possible to use injection preparations: Atropin + Toxogonin + Diazepam, in cases of carbamate poisoning Toxogonin should not be administered. Case reports poisoning are described.
- MeSH
- Antidotes therapeutic use MeSH
- Insecticides poisoning MeSH
- Humans MeSH
- Occupational Diseases etiology therapy MeSH
- Organophosphorus Compounds MeSH
- Poisoning etiology therapy MeSH
- Check Tag
- Humans MeSH
- Publication type
- Case Reports MeSH
- MeSH
- Anti-Arrhythmia Agents pharmacology chemical synthesis MeSH
- Cardiac Complexes, Premature chemically induced prevention & control MeSH
- Atrial Fibrillation chemically induced prevention & control MeSH
- Carbamates pharmacology chemical synthesis MeSH
- Rats MeSH
- Guinea Pigs MeSH
- Arrhythmias, Cardiac chemically induced prevention & control MeSH
- Tocainide analogs & derivatives chemical synthesis MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Guinea Pigs MeSH
- Animals MeSH
- Publication type
- Comparative Study MeSH
Transkarbam 12, an ammonium carbamate formed by the reaction of dodecyl 6-aminohexanoate with carbon dioxide, is a highly active, broad-spectrum, nontoxic, and nonirritant transdermal permeation enhancer. It probably acts by a dual mechanism: a part of its activity is associated with the carbamic acid salt and/or its decomposition in the acidic stratum corneum. The ammonium ester thereby released is an active enhancer species as well, and its activity highly depends on the position of the ester group.
- MeSH
- Administration, Cutaneous MeSH
- Esters MeSH
- Carbamates administration & dosage chemical synthesis chemistry MeSH
- Skin drug effects MeSH
- Permeability drug effects MeSH
- Swine MeSH
- Drug Delivery Systems MeSH
- Structure-Activity Relationship MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
