Angiotensinogen (AGT) represents a key component of the renin-angiotensin-aldosterone system (RAAS). Polymorphisms in the 3' untranslated region (3'UTR) of the AGT gene may alter miRNA binding and cause disbalance in the RAAS. Within this study, we evaluated the possible association of AGT +11525C/A (rs7079) with the clinical characteristics of patients with coronary artery diseases (CAD). Selective coronarography was performed in 652 consecutive CAD patients. Clinical characteristics of the patients, together with peripheral blood samples for DNA isolation, were collected. The genotyping of rs7079 polymorphism was performed with TaqMan® SNP Genotyping Assays. We observed that patients with the CC genotype were referred for coronarography at a younger age compared to those with the AA+CA genotypes (CC vs. AA+CA: 59.1 ± 9.64 vs. 60.91 ± 9.5 (years), p = 0.045). Moreover, according to the logistic regression model, patients with the CC genotype presented more often with restenosis than those with the CA genotype (p = 0.0081). In conclusion, CC homozygotes for rs7079 present with CAD symptoms at a younger age compared with those with the AA+CA genotype, and they are more prone to present with restenosis compared with heterozygotes.
Hemolytic uremic syndrome (HUS) is a type of thrombotic microangiopathy, in the course of which some patients may develop chronic kidney disease (CKD). It is clinically important to investigate the markers of a poor prognosis. The levels of angiotensinogen (AGT) and interleukin-18 (IL-18) in serum and urine were evaluated. Study was conducted in 29 children with a history of HUS. Serum and urine AGT concentration was significantly higher in children after HUS as compared to the control group. No differences depending on the type of HUS and gender were noted. The serum concentration of IL-18 in children after HUS was significantly lower, whereas in urine did not differ significantly between the sick and healthy children. A negative correlation between the concentration of AGT in serum and albuminuria in patients after HUS was detected. The results indicate that the concentration of AGT in serum and urine in children after HUS increases, which may indicate the activation of the intrarenal renin-angiotensin-aldosterone system. The statement, that AGT may be a good biomarker of CKD after acute kidney injury due to HUS requires prospective studies with follow-up from the acute phase of the disease on a larger group of patients. Reduced IL-18 serum concentration in children after HUS with no difference in its urine concentration may indicate a loss of the protective effects of this cytokine on renal function due to previously occurred HUS.
- MeSH
- angiotensinogen krev metabolismus moč MeSH
- biologické markery krev moč MeSH
- chronické selhání ledvin diagnóza metabolismus MeSH
- dítě MeSH
- hemolyticko-uremický syndrom diagnóza metabolismus MeSH
- interleukin-18 krev metabolismus moč MeSH
- kojenec MeSH
- lidé MeSH
- mladiství MeSH
- předškolní dítě MeSH
- reprodukovatelnost výsledků MeSH
- senzitivita a specificita MeSH
- Check Tag
- dítě MeSH
- kojenec MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Klíčová slova
- klinické zkoušky LCZ696 a RLX030,
- MeSH
- aminobutyráty aplikace a dávkování škodlivé účinky terapeutické užití MeSH
- angiotensinogen MeSH
- blokátory receptoru 1 pro angiotenzin II aplikace a dávkování škodlivé účinky terapeutické užití MeSH
- financování organizované MeSH
- hypertenze * farmakoterapie komplikace prevence a kontrola MeSH
- inhibitory ACE aplikace a dávkování škodlivé účinky terapeutické užití MeSH
- lidé MeSH
- metaanalýza jako téma MeSH
- natriuretické peptidy MeSH
- relaxin terapeutické užití MeSH
- renin-angiotensin systém fyziologie imunologie účinky léků MeSH
- srdeční selhání * farmakoterapie komplikace prevence a kontrola MeSH
- statistika jako téma MeSH
- tetrazoly aplikace a dávkování škodlivé účinky terapeutické užití MeSH
- Check Tag
- lidé MeSH
Cíl: Zjistit, zda existuje asociace mezi (–6)A/G a M235T polymorfizmy genu pro angiotenzinogen (ATG) a vnímavostí k roztroušené skleróze a/nebo formou tohoto onemocnění. Soubor a metodika: Celkem 195 nepříbuzných pacientů (49 mužů, 146 žen) s diagnózou roztroušené sklerózy a 126 zdravých kontrol bylo genotypizováno pro dva ATG polymorfizmy metodou polymerázové řetězové reakce s následnou restrikční analýzou. Konečné výsledky byly získány pomocí těchto statistických testů: Fisherův exaktní test, chí-kvadrát a Holmova testu mnohonásobného srovnání. Pro další statistické zpracování bylo využito programu Statistica, verze 8.0 (StratSoft, Inc., Tulsa, OK, USA). Výsledky: Neprokázali jsme statisticky signifikantní rozdíl v genotypové či alelické distribuci pro zkoumané polymorfizmy mezi skupinou nemocných a kontrolními osobami. Ve skupině pacientů se sice dvojnásobní homozygoti MMGG vyskytovali méně často (p = 0,029; OR = 0,57; CI 0,33–0,98), ale přepočtem pomocí Holmova testu výsledky pozbyly signifikance (pcorr = 0,17). Nenalezli jsme statisticky významné rozdíly v distribuci genotypů mezi pacienty s rozdílnými formami onemocnění. Závěr: Naše studie neprokázala, že by (–6)A/G a M235T ATG polymorfizmy měly vliv na vnímavost k roztroušené skleróze, ani že by asociovaly s různými formami tohoto onemocnění.
Aim: To investigate whether there is an association between (–6)A/G a M235T polymorphisms of angiotensinogen (ATG) and susceptibility to multiple sclerosis and/or the course of the disease. Materials and methods: A total of 195 patients (49 men and 146 women) with multiple sclerosis (MS) and 126 healthy controls were investigated for two angiotensinogen polymorphisms using PCR and restriction analysis. The data were analysed with the support Statistica software, version 8.0 (StratSoft, Inc., Tulsa, OK, USA) and using the Fisher’s, Chi-squared and Holm’s tests. Results: We observed no significant differences in genotype or allelic distribution between groups of patients and control subjects for tested ATG polymorphisms. Double homozygotes MMGG were less frequent in the group of MS patients (p = 0.029, Odds ratio = 0.57, CI 0.33–0.98). However, using the Holm’s test for multiple comparisons, the results lacked statistical significance (pcorr= 0.17). We did not find significant differences either in genotype distribution or in allele frequencies among MS patients with the different disease courses. Conclusions: Our study did not find an association between (–6)A/G a M235T polymorphisms of ATG and susceptibility to multiple sclerosis or the course of this disease.
- Klíčová slova
- renin-angiotenzinový systém, angiotenzinogen, polymorfizmus,
- MeSH
- angiotensinogen genetika krev MeSH
- chronicko-progresivní roztroušená skleróza genetika MeSH
- dospělí MeSH
- financování organizované MeSH
- genotyp MeSH
- genotypizační techniky MeSH
- lidé středního věku MeSH
- lidé MeSH
- polymerázová řetězová reakce MeSH
- polymorfismus genetický genetika MeSH
- relabující-remitující roztroušená skleróza genetika MeSH
- renin-angiotensin systém genetika MeSH
- restrikční mapování MeSH
- statistika jako téma MeSH
- studie případů a kontrol MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
Numerous association studies have been involved in studying the angiotensinogen (AGT) variants, AGT plasma levels and relations to cardiovascular diseases, such as hypertension, myocardial infarction, coronary heart disease. To investigate a role of AGT G(-6)A and M235T genetic variants for chronic heart failure (CHF) and advanced atherosclerosis (AA), a total of 240 patients with CHF and 200 patients with AA of the Czech origin were evaluated for the study. The study shows the role of polymorphism AGT G(-6)A in genetic background among advanced atherosclerosis patients and chronic heart failure patients (Pg=0.001). This difference was also observed in comparison of AA patients with subgroup of CHF with dilated cardiomyopathy (Pg=0.02; Pa=0.009), and ischemic heart disease (Pg=0.007). The greatest difference between triple-vessel disease and chronic heart failure groups was observed in frequency of GT haplotype (P<0.001) and GGMT associated genotype (P<0.001). Retrospectively, we found the same trend when the subgroups of CHF were compared to AA group (AA vs. IHD with CHF P<0.001; AA vs. DCM P<0.001). These results suggest AGT genetic variants as a risk factor for chronic heart failure compared to advanced atherosclerosis disease without heart failure, with a strong difference between IHD patients and chronic heart failure patients with ischemic heart disease, especially in haplotypes and associated genotypes. PMID:20945963[PubMed - in process] Free Article LinkOut - more resourcesFull Text SourcesInstitute of Physiology, Academy of Sciences of the Czech Republic, Prague - PDFEBSCO • Supplemental Content Related citations Association of two angiotensinogen gene polymorphisms, M235T and G(-6)A, with chronic heart failure. [Int J Cardiol. 2003] Association of two angiotensinogen gene polymorphisms, M235T and G(-6)A, with chronic heart failure. Goldbergova M, Spinarova L, Spinar J, Toman J, Vasku A, Vacha J. Int J Cardiol. 2003 Jun; 89(2-3):267-72. Association between variants in the genes for leptin, leptin receptor, and proopiomelanocortin with chronic heart failure in the Czech population. [Heart Vessels. 2009] Association between variants in the genes for leptin, leptin receptor, and proopiomelanocortin with chronic heart failure in the Czech population. Bienertová-Vasků JA, Spinarová L, Bienert P, Vasků A. Heart Vessels. 2009 Mar; 24(2):131-7. Epub 2009 Apr 1.Angiotensinogen M235T polymorphism is associated with plasma angiotensinogen and cardiovascular disease. [Am Heart J. 1999] Angiotensinogen M235T polymorphism is associated with plasma angiotensinogen and cardiovascular disease. Winkelmann BR, Russ AP, Nauck M, Klein B, Böhm BO, Maier V, Zotz R, Matheis G, Wolf A, Wieland H, et al. Am Heart J. 1999 Apr; 137(4 Pt 1):698-705. Renin-angiotensin system gene polymorphisms: assessment of the risk of coronary heart disease. [Kardiol Pol. 2003] Renin-angiotensin system gene polymorphisms: assessment of the risk of coronary heart disease. Buraczyńska M, Pijanowski Z, Spasiewicz D, Nowicka T, Sodolski T, Widomska - Czekajska T, Ksiazek A. Kardiol Pol. 2003 Jan; 58(1):1-9. Review A haplotype of the angiotensinogen gene is associated with hypertension in african americans. [Clin Exp Pharmacol Physiol. 2005] Review A haplotype of the angiotensinogen gene is associated with hypertension in african americans. Kumar A, Li Y, Patil S, Jain S. Clin Exp Pharmacol Physiol. 2005 May-Jun; 32(5-6):495-502. See reviews... See all... All links from this record Related Citations Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.Gene Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.Gene (GeneRIF) Gene records that have the current articles as Reference into Function citations (GeneRIFs). NLM staff reviewing the literature while indexing MEDLINE add GeneRIFs manually.HomoloGene HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.Nucleotide Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
- MeSH
- angiotensinogen genetika MeSH
- ateroskleróza genetika MeSH
- dospělí MeSH
- financování organizované MeSH
- frekvence genu genetika MeSH
- genotyp MeSH
- haplotypy MeSH
- hypertenze MeSH
- koronární nemoc genetika MeSH
- lidé středního věku MeSH
- lidé MeSH
- polymorfismus genetický MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- srdeční selhání genetika MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
A total of 195 patients with multiple sclerosis (MS) and 126 controls were investigated for angiotensinogen/(-6)A/G, M235T/and angiotensin converting enzyme I/D gene polymorphisms to test their association with MS susceptibility and/or disease progression using Global Multiple Sclerosis Severity Score (MSSS). We demonstrated a significant association of M235T polymorphism with MSSS. The MM homozygotes had the lowest (3.8), heterozygotes MT higher (5.2) and homozygotes TT the highest (5.4) mean MSSS values (P=0.02). For polymorphisms (-6)A/G of ATG, only a trend was observed (P=0.06), where the homozygotes GG carried lower MSSS values than heterozygotes and homozygotes AA. No significant association with susceptibility was observed. For ACE I/D polymorphism, neither significant differences in the genotype-phenotype study nor in the case-control study were observed.
- MeSH
- alely MeSH
- angiotensin konvertující enzym genetika MeSH
- angiotensinogen krev genetika MeSH
- dospělí MeSH
- genetická predispozice k nemoci MeSH
- genetická variace MeSH
- genotyp MeSH
- heterozygot MeSH
- homozygot MeSH
- lidé MeSH
- polymorfismus genetický MeSH
- progrese nemoci MeSH
- renin-angiotensin systém genetika MeSH
- roztroušená skleróza genetika patologie MeSH
- studie případů a kontrol MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
The objective of the study was to evaluate the prevalence of ACE/ID, AGT/M235T, AT1R/A1166C, CYP11B2/C344T, B2ВKR/ 9-9, ecNOS/4a4b, GNB3/C825T, and ARB2/Gln27Glu gene polymorphisms and their association with endothelium dysfunction (ED) in Uzbek hypertensive patients. The study found an association between ED and AGT M235T gene polymorphism. Genetic models disclosed that the T-allele, MT-, and TT-genotypes of the AGT gene were associated with an increased risk of ED. However, multivariate logistic regression analysis confirmed the negative association between the MM genotype of the AGT gene and positive association between IMT and ED. An association between essential hypertension (EH) in Uzbek males with ACE/ID and GNB3/C825T gene polymorphisms has been demonstrated. There is an
- Klíčová slova
- bradykinin B2-receptor, beta2-adrenoreceptor,
- MeSH
- alely MeSH
- analýza polymorfismu délky amplifikovaných restrikčních fragmentů MeSH
- angiotensin konvertující enzym genetika MeSH
- angiotensinogen genetika MeSH
- cévní endotel * patofyziologie MeSH
- cytochrom P450 CYP11B2 genetika MeSH
- dospělí MeSH
- genotyp MeSH
- heterotrimerní G-proteiny genetika MeSH
- hypertenze * MeSH
- lidé středního věku MeSH
- lidé MeSH
- multivariační analýza MeSH
- polymorfismus genetický * MeSH
- receptor angiotensinu typ 1 genetika MeSH
- synthasa oxidu dusnatého, typ III genetika MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Geografické názvy
- Uzbekistán MeSH
BACKGROUND: Genetic variability in obesity-related genes and the resulting phenotypes are being recognized as major risk factors for colorectal cancer and/or severity of the disease.
- MeSH
- angiotensinogen genetika MeSH
- běloši genetika MeSH
- fenotyp MeSH
- genetická predispozice k nemoci MeSH
- genotyp MeSH
- interleukin-6 genetika MeSH
- jednonukleotidový polymorfismus genetika MeSH
- kolorektální nádory genetika komplikace MeSH
- leptin genetika MeSH
- leptinové receptory genetika MeSH
- lidé MeSH
- obezita genetika komplikace MeSH
- senioři MeSH
- studie případů a kontrol MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Geografické názvy
- Česká republika MeSH
