cytochrom P450 CYP11B2 [Cytochrome P-450 CYP11B2]

tematický
13
Termíny

aldosteronsyntáza
CYP 11B2
CYP11B2
cytochrom P-450 11B2
kortikosteron-18-hydroxylasa
kortikosteron-18-hydroxyláza
kortikosteron-18-monooxygenasa
kortikosteron-18-monooxygenáza
P450c11AS
steroid-18-hydroxylasa
synthasa aldosteronu

 

Aldosterone Synthase
Aldosterone Synthase Cytochrome P-450
Aldosynthase
Corticosterone 18-hydroxylase
Corticosterone 18-monooxygenase
CYP 11B2
CYP11B2
Cytochrome P-450c11AS
Cytochrome P450 11B2
Cytochrome P450Aldo
P450c11AS
Steroid 18-Hydroxylase

Perzistentní odkaz   https://www.medvik.cz/link/D019405
Definice

Mitochondriální enzym cytochromu P450, který katalyzuje 18-hydroxylaci steroidů za přítomnosti molekulárního kyslíku a flavoproteinu specifického pro NADPH. Tento enzym, kódovaný genem CYP11B2, je důležitý při konverzi kortikosteronu na 18-hydroxykortikosteron a následné přeměně na aldosteron.

A mitochondrial cytochrome P450 enzyme that catalyzes the 18-hydroxylation of steroids in the presence of molecular oxygen and NADPH-specific flavoprotein. This enzyme, encoded by CYP11B2 gene, is important in the conversion of CORTICOSTERONE to 18-hydroxycorticosterone and the subsequent conversion to ALDOSTERONE.

Anotace
/antag: coordinate with CYTOCHROME P-450 ENZYME INHIBITORS
podheslo /antagonisté a inhibitory: kombinuj s deskriptorem INHIBITORY CYTOCHROMU P450
DUI
D019405 MeSH Prohlížeč
CUI
M0028872
Předchozí užití
Cytochrome P-450 (1984-1996); Desoxycorticosterone (1979-1982); Steroid 11 beta-Monooxygenase (1994-1996); Steroid Hydroxylases (1979-1993)
Historická pozn.
2015 (1979)
Veřejná pozn.
2015; see ALDOSTERONE SYNTHASE 2003-2014; see CYTOCHROME P-450 CYP11B2 1977-2002; for STEROID 18-HYDROXYLASE see CYTOCHROME P-450 1984-1996, see STEROID 11-HYDROXYLASE 1994-1996, see STEROID HYDROXYLASES 1979-1993, & see DESOXYCORTICOSTERONE 1979-1982

D Chemikálie a léčiva
D08.244 cytochromy 121
D08.244.453.484.500 cytochrom P450 CYP11B2 13
D08.244.453.484.750 steroid-11-beta-hydroxylasa 5
D08.244.453.915 steroidhydroxylasy 16
D08.244.453.915.025 cholesterol-24-hydroxylasa
D08.244.453.915.050 cytochrom P450 CYP11B2 13
D08.244.453.915.099 aromatasa 72
D08.244.453.915.149 cytochrom P450 CYP271 4
D08.244.453.915.200 cholesterol-7-alfa-hydroxylasa 19
D08.244.453.915.730 steroid-12-alfa-hydroxylasa 1
D08.244.453.915.737 steroid-16-alfa-hydroxylasa 5
D08.244.453.915.748 steroid-17-alfa-hydroxylasa 21
D08.244.453.915.750 steroid-11-beta-hydroxylasa 5
D08.244.453.915.760 steroid-21-hydroxylasa 64
D08.244.453.915.880 sterol-14-demethylasa 2
D08.811 enzymy 1 556
D08.811.682 oxidoreduktasy 448
D08.811.682.690 oxygenasy 77
D08.811.682.690.708 oxygenasy se smíšenou funkcí 68
D08.811.682.690.708.170 systém (enzymů) cytochromů P-450 696
D08.811.682.690.708.170.425 rodina 11 cytochromu P450
D08.811.682.690.708.170.425.500 cytochrom P450 CYP11B2 13
D08.811.682.690.708.170.425.750 steroid-11-beta-hydroxylasa 5
D08.811.682.690.708.170.915 steroidhydroxylasy 16
D08.811.682.690.708.170.915.025 cholesterol-24-hydroxylasa
D08.811.682.690.708.170.915.050 cytochrom P450 CYP11B2 13
D08.811.682.690.708.170.915.099 aromatasa 72
D08.811.682.690.708.170.915.150 cytochrom P450 CYP271 4
D08.811.682.690.708.170.915.200 cholesterol-7-alfa-hydroxylasa 19
D08.811.682.690.708.170.915.400 1-alfa-hydroxylasa 25-hydroxyvitaminu D3 4
D08.811.682.690.708.170.915.730 steroid-12-alfa-hydroxylasa 1
D08.811.682.690.708.170.915.737 steroid-16-alfa-hydroxylasa 5
D08.811.682.690.708.170.915.748 steroid-17-alfa-hydroxylasa 21
D08.811.682.690.708.170.915.750 steroid-11-beta-hydroxylasa 5
D08.811.682.690.708.170.915.760 steroid-21-hydroxylasa 64
D08.811.682.690.708.170.915.880 sterol-14-demethylasa 2
D12.776 proteiny 2 595
D12.776.422 hemoproteiny 16
D12.776.422.220 cytochromy 121
D12.776.422.220.453.484 rodina 11 cytochromu P450
D12.776.422.220.453.484.500 cytochrom P450 CYP11B2 13
D12.776.422.220.453.484.750 steroid-11-beta-hydroxylasa 5
D12.776.422.220.453.915 steroidhydroxylasy 16
D12.776.422.220.453.915.025 cholesterol-24-hydroxylasa
D12.776.422.220.453.915.050 cytochrom P450 CYP11B2 13
D12.776.422.220.453.915.099 aromatasa 72
D12.776.422.220.453.915.150 cytochrom P450 CYP271 4
D12.776.422.220.453.915.200 cholesterol-7-alfa-hydroxylasa 19
D12.776.422.220.453.915.400 1-alfa-hydroxylasa 25-hydroxyvitaminu D3 4
D12.776.422.220.453.915.730 steroid-12-alfa-hydroxylasa 1
D12.776.422.220.453.915.737 steroid-16-alfa-hydroxylasa 5
D12.776.422.220.453.915.748 steroid-17-alfa-hydroxylasa 21
D12.776.422.220.453.915.750 steroid-11-beta-hydroxylasa 5
D12.776.422.220.453.915.760 steroid-21-hydroxylasa 64
D12.776.422.220.453.915.880 sterol-14-demethylasa 2

Cyp11b3 protein, rat Chemical MeSH Prohlížeč

corticosterone methyl oxidase I Chemical MeSH Prohlížeč

corticosterone methyl oxidase II Chemical MeSH Prohlížeč