25-Hydroxyvitamin D3 1-alpha-Hydroxylase [1-alfa-hydroxylasa 25-hydroxyvitaminu D3]

topical
3
Terms

25-hydroxycholekalciferol-1-hydroxylasa
CYP27B1
cytochrom P-450 27B1
kalcidiol-1-monooxygenáza

 

25-Hydroxycholecalciferol 1-Hydroxylase
25-Hydroxycholecalciferol-1-Hydroxylase
25-Hydroxyergocalciferol 1-alpha-Hydroxylase
25-Hydroxyvitamin D 1-alpha-Hydroxylase
25-Hydroxyvitamin D(3) 1 alpha-Hydroxylase
25-Hydroxyvitamin D2 1-hydroxylase
Calcidiol 1-Monooxygenase
CYP27B1
Cytochrome P-450 CYP27B1

Persistent link   https://www.medvik.cz/link/D015090
Definition

A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).

DUI
D015090 MeSH Browser
CUI
M0023210
CAS
Calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)
Previous indexing
Hydroxycholecalciferols (1973-1974); Steroid Hydroxylases (1973-1974)
History note
2003 (1975); for 25-HYDROXYVITAMIN D2 1-HYDROXYLASE use STEROID HYDROXYLASES (NM) 1976-2002
Public note
2003; see 25-HYDROXYCHOLECALCIFEROL 1-HYDROXYLASE 1991-2002, see STEROID HYDROXYLASES 1975-1990; 25-HYDROXYVITAMIN D2 1-HYDROXYLASE was indexed under STEROID HYDROXYLASES 1976-2002

Allowable subheadings

AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood 1
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics 2
HI
history
IM
immunology
IP
isolation & purification 1
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine

D Chemicals and Drugs
D08 Enzymes and Coenzymes 7
D08.244 Cytochromes 121
D08.244.453 Cytochrome P-450 Enzyme System 692
D08.244.453.499 Cytochrome P450 Family 27
D08.244.453.499.500 25-Hydroxyvitamin D3 1-alpha-Hydroxylase 3
D08.244.453.499.750 Cholestanetriol 26-Monooxygenase 4
D08.244.453.915 Steroid Hydroxylases 16
D08.244.453.915.025 Cholesterol 24-Hydroxylase
D08.244.453.915.050 Cytochrome P-450 CYP11B2 11
D08.244.453.915.099 Aromatase 72
D08.244.453.915.149 Cholestanetriol 26-Monooxygenase 4
D08.244.453.915.200 Cholesterol 7-alpha-Hydroxylase 19
D08.244.453.915.212 Cholesterol Side-Chain Cleavage Enzyme 6
D08.244.453.915.400 25-Hydroxyvitamin D3 1-alpha-Hydroxylase 3
D08.244.453.915.730 Steroid 12-alpha-Hydroxylase 1
D08.244.453.915.737 Steroid 16-alpha-Hydroxylase 5
D08.244.453.915.748 Steroid 17-alpha-Hydroxylase 21
D08.244.453.915.750 Steroid 11-beta-Hydroxylase 3
D08.244.453.915.760 Steroid 21-Hydroxylase 63
D08.244.453.915.880 Sterol 14-Demethylase 2
D08.811 Enzymes 1 547
D08.811.682 Oxidoreductases 446
D08.811.682.690 Oxygenases 76
D08.811.682.690.708 Mixed Function Oxygenases 68
D08.811.682.690.708.170 Cytochrome P-450 Enzyme System 692
D08.811.682.690.708.170.493 Cytochrome P450 Family 27
D08.811.682.690.708.170.493.500 25-Hydroxyvitamin D3 1-alpha-Hydroxylase 3
D08.811.682.690.708.170.493.750 Cholestanetriol 26-Monooxygenase 4
D08.811.682.690.708.170.915 Steroid Hydroxylases 16
D08.811.682.690.708.170.915.025 Cholesterol 24-Hydroxylase
D08.811.682.690.708.170.915.050 Cytochrome P-450 CYP11B2 11
D08.811.682.690.708.170.915.099 Aromatase 72
D08.811.682.690.708.170.915.150 Cholestanetriol 26-Monooxygenase 4
D08.811.682.690.708.170.915.200 Cholesterol 7-alpha-Hydroxylase 19
D08.811.682.690.708.170.915.212 Cholesterol Side-Chain Cleavage Enzyme 6
D08.811.682.690.708.170.915.400 25-Hydroxyvitamin D3 1-alpha-Hydroxylase 3
D08.811.682.690.708.170.915.730 Steroid 12-alpha-Hydroxylase 1
D08.811.682.690.708.170.915.737 Steroid 16-alpha-Hydroxylase 5
D08.811.682.690.708.170.915.748 Steroid 17-alpha-Hydroxylase 21
D08.811.682.690.708.170.915.750 Steroid 11-beta-Hydroxylase 3
D08.811.682.690.708.170.915.760 Steroid 21-Hydroxylase 63
D08.811.682.690.708.170.915.880 Sterol 14-Demethylase 2
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 577
D12.776.422 Hemeproteins 16
D12.776.422.220 Cytochromes 121
D12.776.422.220.453 Cytochrome P-450 Enzyme System 692
D12.776.422.220.453.499 Cytochrome P450 Family 27
D12.776.422.220.453.499.500 25-Hydroxyvitamin D3 1-alpha-Hydroxylase 3
D12.776.422.220.453.499.750 Cholestanetriol 26-Monooxygenase 4
D12.776.422.220.453.915 Steroid Hydroxylases 16
D12.776.422.220.453.915.025 Cholesterol 24-Hydroxylase
D12.776.422.220.453.915.050 Cytochrome P-450 CYP11B2 11
D12.776.422.220.453.915.099 Aromatase 72
D12.776.422.220.453.915.150 Cholestanetriol 26-Monooxygenase 4
D12.776.422.220.453.915.200 Cholesterol 7-alpha-Hydroxylase 19
D12.776.422.220.453.915.212 Cholesterol Side-Chain Cleavage Enzyme 6
D12.776.422.220.453.915.400 25-Hydroxyvitamin D3 1-alpha-Hydroxylase 3
D12.776.422.220.453.915.730 Steroid 12-alpha-Hydroxylase 1
D12.776.422.220.453.915.737 Steroid 16-alpha-Hydroxylase 5
D12.776.422.220.453.915.748 Steroid 17-alpha-Hydroxylase 21
D12.776.422.220.453.915.750 Steroid 11-beta-Hydroxylase 3
D12.776.422.220.453.915.760 Steroid 21-Hydroxylase 63
D12.776.422.220.453.915.880 Sterol 14-Demethylase 2

CYP27B1 protein, human Chemical MeSH Browser

Back Add