Steroid 17-alpha-Hydroxylase [steroid-17-alfa-hydroxylasa]
- Terms
-
17-alfa-hydroxylasa
17-alfa-hydroxyláza
17-alfa-hydroxyprogesteronaldolasa
17-alfa-hydroxyprogesteronaldoláza
17,20-desmolasa
17,20-desmoláza
17,20-lyasa
17,20-lyáza
CYP17
cytochrom P-450(17 alfa)
P450(c17)
steroid-17-alfa-hydroxyláza
steroid-17-alfa-monooxygenasa
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17 alpha-Hydroxylase
17 alpha-Hydroxylase Cytochrome P-450
17 alpha-Hydroxyprogesterone Aldolase
17,20-Desmolase
17,20-Lyase
CYP17
Cytochrome P-450(17 alpha)
Cytochrome P-450(17-alpha)
Cytochrome P450(17 alpha)
Hydroxyprogesterone Aldolase
P450(c17)
Steroid 17 alpha-Hydroxylase
Steroid 17 alpha-Monooxygenase
Steroid 17-Hydroxylase
Steroid 17-Monooxygenase
Steroid-17-Hydroxylase
A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.
- DUI
- D013254 MeSH Browser
- CUI
- M0020523
- CAS
- Steroid, hydrogen-donor:oxygen oxidoreductase (17 alpha-hydroxylating)
- Previous indexing
- Steroid Hydroxylases (1973-1977)
- History note
- 2003 (1978)
- Public note
- 2003; see STEROID 17 ALPHA-MONOOXYGENASE 1997-2002, see STEROID 17-HYDROXYLASE 1991-1996, see STEROID HYDROXYLASES 1990; for STEROID-17-HYDROXYLASE see STEROID HYDROXYLASES 1978-1989; for 17,20-LYASE see 17 ALPHA-HYDROXYPROGESTERONE ALDOLASE 1996-1997
Combination
- deficiency
- Adrenal Hyperplasia, Congenital
Allowable subheadings
- AD
- administration & dosage 7
- AE
- adverse effects 6
- AN
- analysis
- AI
- antagonists & inhibitors 11
- BI
- biosynthesis
- BL
- blood 2
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry
- CL
- classification
- DE
- drug effects
- EC
- economics
- GE
- genetics 2
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism 2
- PK
- pharmacokinetics 6
- PD
- pharmacology 1
- PH
- physiology
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use 8
- TO
- toxicity
- UL
- ultrastructure
- UR
- urine
CYP17A1 protein, human Chemical MeSH Browser
CYP17A1 protein, rat Chemical MeSH Browser
Cyp17a1 protein, mouse Chemical MeSH Browser
cyp17a1 protein, zebrafish Chemical MeSH Browser
cyp17a2 protein, zebrafish Chemical MeSH Browser
pregnenolone 17-alpha-hydroxylase Chemical MeSH Browser
progesterone 17-alpha-hydroxylase Chemical MeSH Browser