Steroid 12-alpha-Hydroxylase [steroid-12-alfa-hydroxylasa]

topical
1
Terms

12-alfa-hydroxylasa
12-alfa-hydroxyláza
CYP8B1
cytochrom P450 8B1
cytochrom P450 CYP8B1
steroid-12-alfa-hydroxyláza
steroid-12-monooxygenasa
steroid-12-monooxygenáza

 

12-alpha-Hydroxylase
12alpha-Hydroxylase
CYP8B1
Cytochrome P450 8B1
Cytochrome P450 CYP8B1
Steroid 12-Hydroxylase
Steroid 12-Monooxygenase
Steroid-12-Hydroxylase
Steroid-12-Monooxygenase
Sterol 12 alpha-Hydroxylase
Sterol 12-alpha-Hydroxylase

Persistent link   https://www.medvik.cz/link/D013253
Definition

A liver microsomal cytochrome P450 enzyme that catalyzes the 12-alpha-hydroxylation of a broad spectrum of sterols in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP8B1gene, converts 7-alpha-hydroxy-4-cholesten-3-one to 7-alpha-12-alpha-dihydroxy-4-cholesten-3-one and is required in the synthesis of BILE ACIDS from cholesterol.

DUI
D013253 MeSH Browser
CUI
M0020522
CAS
Steroid, hydrogen-donor:oxygen oxidoreductase (12-alpha-hydroxylating)
Previous indexing
Steroid Hydroxylases (1973-1977)
History note
2003 (1978)
Public note
2003; see STEROID 12-MONOOXYGENASE 1997-2002, see STEROID 12-HYDROXYLASE 1991-1996, see STEROID HYDROXYLASES 1978-1990; for STEROID 12-MONOOXYGENASE see STEROID 12-HYDROXYLASE 1978-1996

Allowable subheadings

AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis 1
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine

D Chemicals and Drugs
D08 Enzymes and Coenzymes 7
D08.244 Cytochromes 121
D08.244.453 Cytochrome P-450 Enzyme System 692
D08.244.453.900 Cytochrome P450 Family 8
D08.244.453.900.500 Steroid 12-alpha-Hydroxylase 1
D08.244.453.915 Steroid Hydroxylases 16
D08.244.453.915.025 Cholesterol 24-Hydroxylase
D08.244.453.915.050 Cytochrome P-450 CYP11B2 11
D08.244.453.915.099 Aromatase 72
D08.244.453.915.149 Cholestanetriol 26-Monooxygenase 4
D08.244.453.915.200 Cholesterol 7-alpha-Hydroxylase 19
D08.244.453.915.212 Cholesterol Side-Chain Cleavage Enzyme 6
D08.244.453.915.400 25-Hydroxyvitamin D3 1-alpha-Hydroxylase 3
D08.244.453.915.730 Steroid 12-alpha-Hydroxylase 1
D08.244.453.915.737 Steroid 16-alpha-Hydroxylase 5
D08.244.453.915.748 Steroid 17-alpha-Hydroxylase 21
D08.244.453.915.750 Steroid 11-beta-Hydroxylase 3
D08.244.453.915.760 Steroid 21-Hydroxylase 63
D08.244.453.915.880 Sterol 14-Demethylase 2
D08.811 Enzymes 1 547
D08.811.682 Oxidoreductases 446
D08.811.682.690 Oxygenases 76
D08.811.682.690.708 Mixed Function Oxygenases 68
D08.811.682.690.708.170 Cytochrome P-450 Enzyme System 692
D08.811.682.690.708.170.900 Cytochrome P450 Family 8
D08.811.682.690.708.170.900.500 Steroid 12-alpha-Hydroxylase 1
D08.811.682.690.708.170.915 Steroid Hydroxylases 16
D08.811.682.690.708.170.915.025 Cholesterol 24-Hydroxylase
D08.811.682.690.708.170.915.050 Cytochrome P-450 CYP11B2 11
D08.811.682.690.708.170.915.099 Aromatase 72
D08.811.682.690.708.170.915.150 Cholestanetriol 26-Monooxygenase 4
D08.811.682.690.708.170.915.200 Cholesterol 7-alpha-Hydroxylase 19
D08.811.682.690.708.170.915.212 Cholesterol Side-Chain Cleavage Enzyme 6
D08.811.682.690.708.170.915.400 25-Hydroxyvitamin D3 1-alpha-Hydroxylase 3
D08.811.682.690.708.170.915.730 Steroid 12-alpha-Hydroxylase 1
D08.811.682.690.708.170.915.737 Steroid 16-alpha-Hydroxylase 5
D08.811.682.690.708.170.915.748 Steroid 17-alpha-Hydroxylase 21
D08.811.682.690.708.170.915.750 Steroid 11-beta-Hydroxylase 3
D08.811.682.690.708.170.915.760 Steroid 21-Hydroxylase 63
D08.811.682.690.708.170.915.880 Sterol 14-Demethylase 2
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 577
D12.776.422 Hemeproteins 16
D12.776.422.220 Cytochromes 121
D12.776.422.220.453 Cytochrome P-450 Enzyme System 692
D12.776.422.220.453.900 Cytochrome P450 Family 8
D12.776.422.220.453.900.500 Steroid 12-alpha-Hydroxylase 1
D12.776.422.220.453.915 Steroid Hydroxylases 16
D12.776.422.220.453.915.025 Cholesterol 24-Hydroxylase
D12.776.422.220.453.915.050 Cytochrome P-450 CYP11B2 11
D12.776.422.220.453.915.099 Aromatase 72
D12.776.422.220.453.915.150 Cholestanetriol 26-Monooxygenase 4
D12.776.422.220.453.915.200 Cholesterol 7-alpha-Hydroxylase 19
D12.776.422.220.453.915.212 Cholesterol Side-Chain Cleavage Enzyme 6
D12.776.422.220.453.915.400 25-Hydroxyvitamin D3 1-alpha-Hydroxylase 3
D12.776.422.220.453.915.730 Steroid 12-alpha-Hydroxylase 1
D12.776.422.220.453.915.737 Steroid 16-alpha-Hydroxylase 5
D12.776.422.220.453.915.748 Steroid 17-alpha-Hydroxylase 21
D12.776.422.220.453.915.750 Steroid 11-beta-Hydroxylase 3
D12.776.422.220.453.915.760 Steroid 21-Hydroxylase 63
D12.776.422.220.453.915.880 Sterol 14-Demethylase 2

7 alpha-hydroxy-4-cholesten-3-one-12 alpha monooxygenase Chemical MeSH Browser

7-hydroxycholesterol-12-alpha-hydroxylase Chemical MeSH Browser

chenodeoxycholate hydroxylase Chemical MeSH Browser

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