Steroid 21-Hydroxylase [steroid-21-hydroxylasa]

topical
63
Terms

21-hydroxyláza
cytochrom P-450 21
cytochrom P-450 CYP21
cytochrom P-450(c-21)
cytochrom P450c21
enzym P450c21
progesteron-21-hydroxylasa
progesteron-21-hydroxyláza
steroid-21-hydroxyláza
steroid-21-monooxygenasa
steroid-21-monooxygenáza

 

21-Hydroxylase
Cytochrome P-450 21-Hydroxylase
Cytochrome P-450 c21
Cytochrome P-450 CYP21
Cytochrome P-450(c-21)
Cytochrome P450c21
Progesterone 21-Hydroxylase
Steroid 21-Monooxygenase
Steroid-21-Hydroxylase

Persistent link   https://www.medvik.cz/link/D013255
Definition

An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP21 gene, converts progesterones to precursors of adrenal steroid hormones (CORTICOSTERONE; HYDROCORTISONE). Defects in CYP21 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).

DUI
D013255 MeSH Browser
CUI
M0020524
CAS
Steroid,hydrogen-donor:oxygen oxidoreductase (21-hydroxylating)
Previous indexing
Steroid Hydroxylases (1973-1977)
History note
2003 (1978)
Public note
2003; see STE see STEROID 21-MONOOXYGENASE 1997-2002, see STEROID 21-HYDROXYLASE 1991-1996, see STEROID HYDROXYLASES 1978-1990; for STEROID 21-MONOOXYGENASE see STEROID 21-HYDROXYLASE 1978-1996; CYTOCHROME P-450 C21 was indexed under STEROID 21-HYDROXYLASE 2004 & under CYTOCHROME P-450 ENZYME SYSTEM 1996-2003

Combination

deficiency
Adrenal Hyperplasia, Congenital

Allowable subheadings

AD
administration & dosage
AE
adverse effects 1
AN
analysis 2
AI
antagonists & inhibitors 3
BI
biosynthesis 1
BL
blood 7
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DE
drug effects
EC
economics
GE
genetics 19
HI
history
IM
immunology 1
IP
isolation & purification
ME
metabolism 8
PK
pharmacokinetics
PD
pharmacology
PH
physiology 1
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use 1
TO
toxicity
UL
ultrastructure
UR
urine

D Chemicals and Drugs
D08 Enzymes and Coenzymes 7
D08.244 Cytochromes 121
D08.244.453 Cytochrome P-450 Enzyme System 692
D08.244.453.493 Cytochrome P450 Family 21
D08.244.453.493.500 Steroid 21-Hydroxylase 63
D08.244.453.915 Steroid Hydroxylases 16
D08.244.453.915.025 Cholesterol 24-Hydroxylase
D08.244.453.915.050 Cytochrome P-450 CYP11B2 11
D08.244.453.915.099 Aromatase 72
D08.244.453.915.149 Cholestanetriol 26-Monooxygenase 4
D08.244.453.915.200 Cholesterol 7-alpha-Hydroxylase 19
D08.244.453.915.212 Cholesterol Side-Chain Cleavage Enzyme 6
D08.244.453.915.400 25-Hydroxyvitamin D3 1-alpha-Hydroxylase 3
D08.244.453.915.730 Steroid 12-alpha-Hydroxylase 1
D08.244.453.915.737 Steroid 16-alpha-Hydroxylase 5
D08.244.453.915.748 Steroid 17-alpha-Hydroxylase 21
D08.244.453.915.750 Steroid 11-beta-Hydroxylase 3
D08.244.453.915.760 Steroid 21-Hydroxylase 63
D08.244.453.915.880 Sterol 14-Demethylase 2
D08.811 Enzymes 1 547
D08.811.682 Oxidoreductases 446
D08.811.682.690 Oxygenases 76
D08.811.682.690.708 Mixed Function Oxygenases 68
D08.811.682.690.708.170 Cytochrome P-450 Enzyme System 692
D08.811.682.690.708.170.463 Cytochrome P450 Family 21
D08.811.682.690.708.170.463.500 Steroid 21-Hydroxylase 63
D08.811.682.690.708.170.915 Steroid Hydroxylases 16
D08.811.682.690.708.170.915.025 Cholesterol 24-Hydroxylase
D08.811.682.690.708.170.915.050 Cytochrome P-450 CYP11B2 11
D08.811.682.690.708.170.915.099 Aromatase 72
D08.811.682.690.708.170.915.150 Cholestanetriol 26-Monooxygenase 4
D08.811.682.690.708.170.915.200 Cholesterol 7-alpha-Hydroxylase 19
D08.811.682.690.708.170.915.212 Cholesterol Side-Chain Cleavage Enzyme 6
D08.811.682.690.708.170.915.400 25-Hydroxyvitamin D3 1-alpha-Hydroxylase 3
D08.811.682.690.708.170.915.730 Steroid 12-alpha-Hydroxylase 1
D08.811.682.690.708.170.915.737 Steroid 16-alpha-Hydroxylase 5
D08.811.682.690.708.170.915.748 Steroid 17-alpha-Hydroxylase 21
D08.811.682.690.708.170.915.750 Steroid 11-beta-Hydroxylase 3
D08.811.682.690.708.170.915.760 Steroid 21-Hydroxylase 63
D08.811.682.690.708.170.915.880 Sterol 14-Demethylase 2
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 577
D12.776.422 Hemeproteins 16
D12.776.422.220 Cytochromes 121
D12.776.422.220.453 Cytochrome P-450 Enzyme System 692
D12.776.422.220.453.493 Cytochrome P450 Family 21
D12.776.422.220.453.493.500 Steroid 21-Hydroxylase 63
D12.776.422.220.453.915 Steroid Hydroxylases 16
D12.776.422.220.453.915.025 Cholesterol 24-Hydroxylase
D12.776.422.220.453.915.050 Cytochrome P-450 CYP11B2 11
D12.776.422.220.453.915.099 Aromatase 72
D12.776.422.220.453.915.150 Cholestanetriol 26-Monooxygenase 4
D12.776.422.220.453.915.200 Cholesterol 7-alpha-Hydroxylase 19
D12.776.422.220.453.915.212 Cholesterol Side-Chain Cleavage Enzyme 6
D12.776.422.220.453.915.400 25-Hydroxyvitamin D3 1-alpha-Hydroxylase 3
D12.776.422.220.453.915.730 Steroid 12-alpha-Hydroxylase 1
D12.776.422.220.453.915.737 Steroid 16-alpha-Hydroxylase 5
D12.776.422.220.453.915.748 Steroid 17-alpha-Hydroxylase 21
D12.776.422.220.453.915.750 Steroid 11-beta-Hydroxylase 3
D12.776.422.220.453.915.760 Steroid 21-Hydroxylase 63
D12.776.422.220.453.915.880 Sterol 14-Demethylase 2

CYP21A2 protein, human Chemical MeSH Browser

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Cyp21a1 protein, mouse Chemical MeSH Browser

Cyp21a1 protein, rat Chemical MeSH Browser

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