Gastric cancer is a common oncological disease. Although enormous efforts have been expended, possible therapeutic modalities are still limited. For this reason, new therapeutic approaches and agents are highly requested and intensively developed. One strategy is the application of natural agents, such as curcumin, with proven anticancer effects and low toxicity for patients. Therefore, this review discusses the potential application of curcumin in the therapy of gastric cancer and its potential incorporation in therapeutic regimens. Because one of the largest impediments for widespread curcumin application is its limited bioavailability (caused mainly by its very low water solubility), studied strategies (drug delivery systems and curcumin derivatization) aimed to solve this obstacle are discussed in more detail.

1st Department of Surgery Department of Abdominal Thoracic Surgery and Traumatology 1st Faculty of Medicine Charles University and General University Hospital Prague U Nemocnice 2 128 08 Prague 2 Czech Republic

BIOCEV 1st Faculty of Medicine Charles University Průmyslová 595 252 50 Vestec Czech Republic

BIOCEV 1st Faculty of Medicine Charles University Průmyslová 595 252 50 Vestec Czech Republic; Department of Analytical Chemistry Faculty of Chemical Engineering University of Chemistry and Technology Technická 5 166 28 Prague 6 Czech Republic

BIOCEV 1st Faculty of Medicine Charles University Průmyslová 595 252 50 Vestec Czech Republic; Department of Pediatrics and Adolescent Medicine 1st Faculty of Medicine Charles University and General University Hospital Prague Ke Karlovu 2 121 00 Prague 2 Czech Republic

BIOCEV 1st Faculty of Medicine Charles University Průmyslová 595 252 50 Vestec Czech Republic; Department of Pediatrics and Adolescent Medicine 1st Faculty of Medicine Charles University and General University Hospital Prague Ke Karlovu 2 121 00 Prague 2 Czech Republic; Department of Analytical Chemistry Faculty of Chemical Engineering University of Chemistry and Technology Technická 5 166 28 Prague 6 Czech Republic

BIOCEV 1st Faculty of Medicine Charles University Průmyslová 595 252 50 Vestec Czech Republic; Research and Development Center C2P s r o Jungmannova 101 503 51 Chlumec nad Cidlinou Czech Republic

Department of Analytical Chemistry Faculty of Chemical Engineering University of Chemistry and Technology Technická 5 166 28 Prague 6 Czech Republic

Department of Pediatrics and Adolescent Medicine 1st Faculty of Medicine Charles University and General University Hospital Prague Ke Karlovu 2 121 00 Prague 2 Czech Republic

Food Research Institute Prague Radiová 1285 7 1285 7 Prague 10 Czech Republic

Research and Development Center C2P s r o Jungmannova 101 503 51 Chlumec nad Cidlinou Czech Republic

Citace poskytuje Crossref.org

Curcumin: A Potential Weapon in the Prevention and Treatment of Head and Neck Cancer

Investigating antibacterial and anti-inflammatory properties of synthetic curcuminoids

Circulating Tumour Cells (CTCs) in NSCLC: From Prognosis to Therapy Design