Mitochondriální cytochrom P450, který katalyzuje 1-alfa-hydroxylaci 25-hydroxyvitaminu D3 (známého také jako 25-hydroxycholekalciferol) za přítomnosti molekulárního kyslíku a NADPH-cytochrom c-reduktázy. Tento enzym je kódovaný genem CYP27B1. Přeměňuje 25-hydroxyvitamin D3 na 1-alfa,25-dihydroxyvitamin D3, který je aktivní formou vitaminu D pro regulaci růstu kostí a metabolismu vápníku. Tento enzym také působí na rostlinný 25-hydroxyvitamin D2 (ergokalciferol).

A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).

DUI

D015090 MeSH Prohlížeč

CUI

M0023210

CAS

Calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)

Předchozí užití

Hydroxycholecalciferols (1973-1974); Steroid Hydroxylases (1973-1974)

Historická pozn.

2003 (1975); for 25-HYDROXYVITAMIN D2 1-HYDROXYLASE use STEROID HYDROXYLASES (NM) 1976-2002

Veřejná pozn.

2003; see 25-HYDROXYCHOLECALCIFEROL 1-HYDROXYLASE 1991-2002, see STEROID HYDROXYLASES 1975-1990; 25-HYDROXYVITAMIN D2 1-HYDROXYLASE was indexed under STEROID HYDROXYLASES 1976-2002