Background: Lipocalin-2 (LCN2) is a protein that has been associated with skeletal muscle regeneration, but details regarding its role in Arthritis remain unclear. The aim of the current study was to investigate LCN2 levels of Arthritis patients and its relationship with oxidative and antioxidative factors.Methods: The study includes (125) blood samples of persons aged 20-65 years were divided into a control group (apparently healthy) consisting of 55 samples [31female, 24 males] and a Patient group consisting of 70 samples [37female, 33 males] who were attending the bone diseases consultation unit at the Ibn Sina Teaching Hospital in Mosul, Iraq. Venous blood samples (10 ml) were collected after overnight fasting. To conduct Clinical analyses: Serum LCN2 level was determined by ELISA, also Malonaldehyde, glutathione, vitamin E, vitamin C, peroxy nitrite, peroxidase, and aryl esterase were estimated.Results: The findings revealed a significant increase in the levels of LCN2 in Arthritis compared to the control group and there was a significant decrease in the concentration of vitamin C, glutathione, vitamin E and the activity of the arylesterase in serum of patients with arthritis compared with the control group. Also, a significant increase in the activity of peroxidase, concentration of peroxynitrite and malondialdehyde for patients than a control group.Conclusion: These findings imply that LCN2 may play a substantial role in iron-related oxidative stress damage in arthritis. Thus a therapeutic candidate target for treatment.
- MeSH
- adrenalektomie MeSH
- adrenokortikotropní hormon MeSH
- artritida enzymologie chemicky indukované krev MeSH
- ceruloplasmin analýza krev sekrece MeSH
- experimenty na zvířatech MeSH
- katecholoxidasa analýza krev MeSH
- klinické enzymatické testy MeSH
- krysa rodu rattus MeSH
- Check Tag
- krysa rodu rattus MeSH
- MeSH
- artritida * diagnóza imunologie krev MeSH
- biologické markery krev MeSH
- C-reaktivní protein imunologie izolace a purifikace MeSH
- chronická nemoc MeSH
- glykoproteiny izolace a purifikace MeSH
- hemaglutinační testy metody využití MeSH
- imunoglobuliny imunologie krev MeSH
- imunologické testy * metody využití MeSH
- lidé MeSH
- sérum chemie imunologie MeSH
- synoviální tekutina * imunologie metabolismus MeSH
- synovitida imunologie krev MeSH
- transaminasy imunologie krev MeSH
- Check Tag
- lidé MeSH