Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder in the elderly population. Numerous epidemiological and experimental studies have demonstrated that patients who suffer from obesity or type 2 diabetes mellitus have a higher risk of cognitive dysfunction and AD. Several recent studies demonstrated that food intake-lowering (anorexigenic) peptides have the potential to improve metabolic disorders and that they may also potentially be useful in the treatment of neurodegenerative diseases. In this review, the neuroprotective effects of anorexigenic peptides of both peripheral and central origins are discussed. Moreover, the role of leptin as a key modulator of energy homeostasis is discussed in relation to its interaction with anorexigenic peptides and their analogs in AD-like pathology. Although there is no perfect experimental model of human AD pathology, animal studies have already proven that anorexigenic peptides exhibit neuroprotective properties. This phenomenon is extremely important for the potential development of new drugs in view of the aging of the human population and of the significantly increasing incidence of AD.

• Klíčová slova
• Alzheimer’s disease pathology, anorexigenic neuropeptides, experimental rodent models, leptin,
• MeSH
• Alzheimerova nemoc metabolismus   prevence a kontrola   MeSH
• anorektika metabolismus   farmakologie   MeSH
• energetický metabolismus účinky léků   MeSH
• homeostáza účinky léků   MeSH
• kyselina pyrrolidonkarboxylová analogy a deriváty   metabolismus   farmakologie   MeSH
• leptin metabolismus   MeSH
• lidé MeSH
• modely nemocí na zvířatech MeSH
• neuroprotektivní látky farmakologie   MeSH
• oligopeptidy metabolismus   farmakologie   MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• přehledy MeSH
• Názvy látek
• anorektika MeSH
• kyselina pyrrolidonkarboxylová MeSH
• leptin MeSH
• neuroprotektivní látky MeSH
• oligopeptidy MeSH
• pyroglutamyl-histidyl-glycine MeSH Prohlížeč

An anorectic substance similar to satietin was purified from ethanolic-acid precipitate of rat urine by gel filtration and ion exchange chromatography. The obtained glycoprotein (molecular mass 67 kDa) reduced food intake after intraperitoneal and intracisternal administration in mice in a dose-dependent manner (in the range of 5-80 mg/kg). The anorectic effect was specific. In the presence of sodium dodecylsulphate the substance dissociated into small proteins with a molecular mass of 9-11 kDa. Its anorectic effect was long lasting and differed from that of the anorectic peptide cholecystokinin octapeptide. Our finding supports the idea that anorectic protein isolated from plasma, membranes, and urine may be related substances.

• MeSH
• anorektika metabolismus   MeSH
• glykopeptidy chemie   moč   MeSH
• glykoproteiny moč   MeSH
• krysa rodu Rattus MeSH
• morčata MeSH
• myši MeSH
• nechutenství metabolismus   MeSH
• potkani Wistar MeSH
• přijímání potravy účinky léků   MeSH
• sinkalid farmakologie   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• morčata MeSH
• mužské pohlaví MeSH
• myši MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• anorektika MeSH
• glykopeptidy MeSH
• glykoproteiny MeSH
• satietin MeSH Prohlížeč
• sinkalid MeSH