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MeSH: nenasycené mastné kyseliny-terapeutické užití

7 záznamů v PubMed Filtry

Článek

Omega-3 PUFA of marine origin limit diet-induced obesity in mice by reducing cellularity of adipose tissue

Lipids. 2004 Dec ; 39 (12) : 1177-85.

ISSN 0024-4201
Zdroj

Omega-3 PUFA of marine origin reduce adiposity in animals fed a high-fat diet. Our aim was to learn whether EPA and DHA could limit development of obesity and reduce cellularity of adipose tissue and whether other dietary FA could influence the effect of EPA/DHA. Weight gain induced by composite high-fat diet in C57BL/6J mice was limited when the content of EPA/DHA was increased from 1 to 12% (wt/wt) of dietary lipids. Accumulation of adipose tissue was reduced, especially of the epididymal fat. Low ratio of EPA to DHA promoted the effect. A higher dose of EPA/DHA was required to reduce adiposity when admixed to diets that did not promote obesity, the semisynthetic high-fat diets rich in EFA, either alpha-linolenic acid (ALA, 18:3 n-3, the precursor of EPA and DHA) or linoleic (18:2 n-6) acid. Quantification of adipose tissue DNA revealed that except for the diet rich in ALA the reduction of epididymal fat was associated with 34-50% depression of tissue cellularity, similar to the 30% caloric restriction in the case of the high-fat composite diet. Changes in plasma markers and adipose gene expression indicated improvement of lipid and glucose metabolism due to EPA/DHA even in the context of the diet rich in ALA. Our results document augmentation of the antiadipogenic effect of EPA/DHA during development of obesity and suggest that EPA/DHA could reduce accumulation of body fat by limiting both hypertrophy and hyperplasia of fat cells. Increased dietary intake of EPA/DHA may be beneficial regardless of the ALA intake.

MeSH
dieta MeSH
myši MeSH
nenasycené mastné kyseliny terapeutické užití MeSH
obezita dietoterapie etiologie patologie MeSH
omega-3 mastné kyseliny terapeutické užití MeSH
tuková tkáň patologie MeSH
zvířata MeSH
Check Tag
myši MeSH
zvířata MeSH
Publikační typ
časopisecké články MeSH
práce podpořená grantem MeSH
Názvy látek
nenasycené mastné kyseliny MeSH
omega-3 mastné kyseliny MeSH

Článek

Essential fatty acids and related molecular and cellular mechanisms in multiple sclerosis: new looks at old concepts

Mayer, M
Autor Mayer, M Department of Rehabilitation, Faculty Hospital, Olomouc, Czech Republic. michal@tunw.upol.cz

Folia biologica. 1999 ; 45 (4) : 133-41.

Folia Biol (Praha)
ISSN 0015-5500
Zdroj

Essential polyunsaturated fatty acids, their metabolism and their effects represent a ubiquitous system important for cellular membrane stability, for immunological and inflammatory regulations, for inter- and intracellular signalling. There are complex links to other regulatory and effector mechanisms - to the reactive oxygen species, nitric oxide and peroxynitrite anion, to eicosanoids and related compounds. The relation of polyunsaturated acids to multiple sclerosis was extensively discussed some time ago. Recently, a number of data placing these concepts in a new light have emerged, which are reviewed in the present article. The recent knowledge indicates that this topic deserves further attention in both the basic and the clinical research of multiple sclerosis.