It is now suggested that the inhibition of biological programs that are associated with the tumor microenvironment may be critical to the diagnostics, prevention and treatment of cancer. On the other hand, a suitable wound microenvironment would accelerate tissue repair and prevent extensive scar formation. In the present review paper, we define key signaling molecules (growth factors, cytokines, chemokines, and galectins) involved in the formation of the tumor microenvironment that decrease overall survival and increase drug resistance in cancer suffering patients. Additional attention will also be given to show whether targeted modulation of these regulators promote tissue regeneration and wound management. Whole-genome transcriptome profiling, in vitro and animal experiments revealed that interleukin 6, interleukin 8, chemokine (C-X-C motif) ligand 1, galectin-1, and selected proteins of the extracellular matrix (e.g., fibronectin) do have similar regulation during wound healing and tumor growth. Published data demonstrate remarkable similarities between the tumor and wound microenvironments. Therefore, tailor made manipulation of cancer stroma can have important therapeutic consequences. Moreover, better understanding of cancer cell-stroma interaction can help to improve wound healing by supporting granulation tissue formation and process of reepithelization of extensive and chronic wounds as well as prevention of hypertrophic scars and formation of keloids.

• Klíčová slova
• cancer, cytokine, galectin, stem cell, tissue repair,
• MeSH
• buněčné mikroprostředí MeSH
• cytokiny metabolismus   MeSH
• galektiny metabolismus   MeSH
• hojení ran MeSH
• imunitní systém cytologie   imunologie   metabolismus   MeSH
• keloid metabolismus   patologie   MeSH
• lidé MeSH
• mezibuněčné signální peptidy a proteiny metabolismus   MeSH
• nádorové kmenové buňky metabolismus   patologie   MeSH
• nádorové mikroprostředí * MeSH
• nádory imunologie   metabolismus   patologie   MeSH
• rány a poranění imunologie   metabolismus   patologie   MeSH
• signální transdukce * MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• Názvy látek
• cytokiny MeSH
• galektiny MeSH
• mezibuněčné signální peptidy a proteiny MeSH

Inflammation and injury influence plasma proteins and immunoglobulins. They respond to noxious agents by a rise of c-reactive protein (CRP), orosomucoid, fibrinogen, haptaglobulin, alpha-1 antitrypsin, ceruloplasmin, C 3 and C 4 components of complement. The rate of rise and return to normal values varies. CRP reacts most'promptly. The following substances react by a decline of the levels: albumin, prealbumin, transferrin, alpha-1 lipoprotein and immunoglobulins. Investigation of the patient's immunological state is of prognostic value. CRP, orosomucoid, albumin and prealbumin are considered the most valuable indicators; from their values the so-called PINI index can be calculated and the patients can be divided into five prognostic zones. To threatened patients all-round care must be devoted incl. aimed provision of ATB and immunoprotective substances.

• MeSH
• C-reaktivní protein analýza   MeSH
• dítě MeSH
• imunoglobuliny analýza   MeSH
• infekce krev   imunologie   MeSH
• komplement analýza   MeSH
• lidé MeSH
• proteiny akutní fáze analýza   MeSH
• rány a poranění krev   imunologie   MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• Názvy látek
• C-reaktivní protein MeSH
• imunoglobuliny MeSH
• komplement MeSH
• proteiny akutní fáze MeSH

The effect of human recombinant interleukin-2 (IL-2) on the proliferative and cytotoxic response of peripheral blood mononuclear cells was analyzed in 12 severely injured patients. The in vitro proliferative response (measured from tritiated thymidine uptake) was normal during the first post-injury week, but rapidly decreased from the second week. The cytotoxic response to natural killer cell-resistant target T24 was likewise diminished from the second week. To clarify if the defect in cytotoxic response was due to numerical reduction of precursors or to reduced responsiveness, limiting dilution assay was introduced. No post-trauma reduction in precursor numbers was observed. These data collectively suggest that, in addition to impaired IL-2 production, there is an endogenous defect in IL-2 responsiveness. In the context of high incidence of septic complications, the observations may be clinically important.

• MeSH
• buněčné dělení MeSH
• buňky NK imunologie   MeSH
• cytotoxické testy imunologické MeSH
• dospělí MeSH
• interleukin-2 farmakologie   MeSH
• kultivované buňky MeSH
• leukocyty mononukleární imunologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• polytrauma imunologie   MeSH
• rány a poranění imunologie   MeSH
• senioři MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• interleukin-2 MeSH

• MeSH
• aktivace lymfocytů MeSH
• enterální výživa * MeSH
• lidé MeSH
• parenterální výživa * MeSH
• rány a poranění imunologie   terapie   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH

Immunocomplexes from the blood serum of 129 autopsied males and females from newborn age up to 95 years were examined by means of the PEGIKEM test. In cases of sudden death without inflammatory changes the mean value of immunocomplexes x = 22.794, s = 23.426; in cases of death due to injury without inflammatory changes x = 22.935, s = 21.947. In sudden death with inflammatory changes x = 41.154, s = 50.97; in death due to injury with inflammatory changes x = 54.500, s = 34.757. In inflammatory changes the values of immunocomplexes are increased statisticaly significantly; in sudden death p = 0.0485, in death due to injury p = 0.0193 when compared with controls without inflammatory changes. In sudden death, no statistically significant differences were found between the age groups 0-1 year, 2-15 years and above 16 years. In sudden death and that due to injury, the lowest values of immunocomplexes were found in infants to 1 year of age. Increased values of immunocomplexes may also be found in cases without inflammatory changes and, in contrast to it, may be low in inflammatory changes. Dependence of immunocomplexes upon the duration of the postmortem period was neither proved nor excluded by means of the statistical method. It is suitable to examine immunocomplexes immediately after the withdrawal of blood sample, fluctuation of values may occur in vitro (in cases of drowning and phylonephritis). The examination of immunocomplexes in postmortem blood is possible and in some cases suitably supplements the spectrum of diagnostic methods.

• MeSH
• dítě MeSH
• dospělí MeSH
• imunokomplex analýza   MeSH
• kojenec MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• náhlá smrt MeSH
• novorozenec MeSH
• předškolní dítě MeSH
• rány a poranění imunologie   MeSH
• senioři MeSH
• soudní lékařství * MeSH
• Check Tag
• dítě MeSH
• dospělí MeSH
• kojenec MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• novorozenec MeSH
• předškolní dítě MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• Názvy látek
• imunokomplex MeSH