Excessive connective tissue accumulation, a hallmark of hypertrophic scaring, results in progressive deterioration of the structure and function of organs. It can also be seen during tumor growth and other fibroproliferative disorders. These processes result from a wide spectrum of cross-talks between mesenchymal, epithelial and inflammatory/immune cells that have not yet been fully understood. In the present review, we aimed to describe the molecular features of fibroblasts and their interactions with immune and epithelial cells and extracellular matrix. We also compared different types of fibroblasts and their roles in skin repair and regeneration following burn injury. In summary, here we briefly review molecular changes underlying hypertrophic scarring following burns throughout all basic wound healing stages, i.e. during inflammation, proliferation and maturation.
- Klíčová slova
- burn, cell interaction, pathological scar, skin, stem cell, wound healing,
- MeSH
- epitelové buňky metabolismus patologie MeSH
- extracelulární matrix metabolismus patologie MeSH
- fibroblasty metabolismus patologie MeSH
- hojení ran genetika MeSH
- jizva hypertrofická genetika imunologie patologie MeSH
- lidé MeSH
- popálení genetika patologie MeSH
- proliferace buněk genetika MeSH
- zánět genetika patologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
It is now suggested that the inhibition of biological programs that are associated with the tumor microenvironment may be critical to the diagnostics, prevention and treatment of cancer. On the other hand, a suitable wound microenvironment would accelerate tissue repair and prevent extensive scar formation. In the present review paper, we define key signaling molecules (growth factors, cytokines, chemokines, and galectins) involved in the formation of the tumor microenvironment that decrease overall survival and increase drug resistance in cancer suffering patients. Additional attention will also be given to show whether targeted modulation of these regulators promote tissue regeneration and wound management. Whole-genome transcriptome profiling, in vitro and animal experiments revealed that interleukin 6, interleukin 8, chemokine (C-X-C motif) ligand 1, galectin-1, and selected proteins of the extracellular matrix (e.g., fibronectin) do have similar regulation during wound healing and tumor growth. Published data demonstrate remarkable similarities between the tumor and wound microenvironments. Therefore, tailor made manipulation of cancer stroma can have important therapeutic consequences. Moreover, better understanding of cancer cell-stroma interaction can help to improve wound healing by supporting granulation tissue formation and process of reepithelization of extensive and chronic wounds as well as prevention of hypertrophic scars and formation of keloids.
- Klíčová slova
- cancer, cytokine, galectin, stem cell, tissue repair,
- MeSH
- buněčné mikroprostředí MeSH
- cytokiny metabolismus MeSH
- galektiny metabolismus MeSH
- hojení ran MeSH
- imunitní systém cytologie imunologie metabolismus MeSH
- keloid metabolismus patologie MeSH
- lidé MeSH
- mezibuněčné signální peptidy a proteiny metabolismus MeSH
- nádorové kmenové buňky metabolismus patologie MeSH
- nádorové mikroprostředí * MeSH
- nádory imunologie metabolismus patologie MeSH
- rány a poranění imunologie metabolismus patologie MeSH
- signální transdukce * MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- cytokiny MeSH
- galektiny MeSH
- mezibuněčné signální peptidy a proteiny MeSH
