In order to determine whether central serotonin (5-HT) activity is related to sensitivity of insulin receptors, 19 healthy volunteers with normal basal glycemia and HbAlc were studied. The relationship between prolactin response to D-fenfluramine (delta PRL) in a challenge test and metabolic clearance rates (MCR) of glucose during the hyperinsulinemic-euglycemic clamp technique was evaluated. delta PRL had been chosen as a correlate of central 5-HT activity. Two levels of insulin concentration of approximately 70 mU/l (MCRsubmax) and 2000 mU/l (MCRmax) were used in a clamp, each for a duration of 120 min. A negative correlation was found between delta PRL and MCRsubmax (r = -0.55, P < 0.02) and between delta PRL and MCRmax (r = -0.51, P < 0.03). We did not find any correlation between the prolactin response to D-fenfluramine and body weight, body mass index (BMI) or waist and hip circumference (WHR). The data support the hypothesis of a close connection between 5-HT activity in the brain and peripheral sensitivity to insulin. The possible physiological mechanisms of this connection are discussed.

• MeSH
• dospělí MeSH
• fenfluramin MeSH
• glykemický clamp MeSH
• glykovaný hemoglobin metabolismus   MeSH
• index tělesné hmotnosti MeSH
• inzulinová rezistence fyziologie   MeSH
• krevní glukóza metabolismus   MeSH
• lidé MeSH
• mozek fyziologie   MeSH
• prolaktin krev   MeSH
• receptor inzulinu fyziologie   MeSH
• serotonin fyziologie   MeSH
• serotoninové látky MeSH
• tělesná konstituce MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• fenfluramin MeSH
• glykovaný hemoglobin MeSH
• krevní glukóza MeSH
• prolaktin MeSH
• receptor inzulinu MeSH
• serotonin MeSH
• serotoninové látky MeSH

The relationship between specific insulin binding to insulin receptors on erythrocytes and erythrocyte membrane phospholipid fatty acid pattern was evaluated in 11 healthy men. A significant negative correlation between insulin binding and the proportion of w-6 family essential fatty acids, especially linoleic acid (r = -0.82, p less than 0.01) and arachidonic acid (r = -0.73, p less than 0.05) in erythrocyte membrane was found. On the other hand significant positive correlation between insulin binding and the content of nonessential fatty acids (r = +0.65, p less than 0.05) was seen. Data presented support the hypothesis that the fatty acid composition of membrane phospholipids may modify properties of insulin receptors.

• MeSH
• dospělí MeSH
• erytrocytární membrána analýza   MeSH
• erytrocyty metabolismus   MeSH
• fosfolipidy krev   MeSH
• inzulin metabolismus   MeSH
• kyseliny arachidonové krev   MeSH
• kyseliny linolové krev   MeSH
• lidé středního věku MeSH
• lidé MeSH
• mastné kyseliny krev   MeSH
• membránové lipidy krev   MeSH
• receptor inzulinu fyziologie   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• fosfolipidy MeSH
• inzulin MeSH
• kyseliny arachidonové MeSH
• kyseliny linolové MeSH
• mastné kyseliny MeSH
• membránové lipidy MeSH
• receptor inzulinu MeSH

The term compound receptors (C.R.) is used here to describe reversible molecular complexes in the cell membrane which attain their final biologically active structure by rearrangement and assembly of several structural subunits. The C.R. to be discussed involve the participation of the glycoproteins belonging to the major histocompatibility complex (MHC), notably of class I molecules which are themselves reversible compounds of a heavy chain and a light chain (beta 2-m). The main thesis of this discussion is the postulate that the fundamental immunological phenomenon known as MHC restriction is due to the formation in the membrane of reversible C.R. with additional roles in the physiology of the cell. The interaction between MHC class I molecules and insulin receptor molecules will be mentioned as an illustration of the general hypothesis.

• MeSH
• bezobratlí genetika   imunologie   MeSH
• biologická evoluce MeSH
• buněčná membrána imunologie   fyziologie   MeSH
• hlavní histokompatibilní komplex * MeSH
• krysa rodu Rattus MeSH
• lidé MeSH
• myši MeSH
• receptor inzulinu fyziologie   MeSH
• receptory buněčného povrchu fyziologie   MeSH
• T-lymfocyty imunologie   MeSH
• zvířata MeSH
• Check Tag
• krysa rodu Rattus MeSH
• lidé MeSH
• myši MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• receptor inzulinu MeSH
• receptory buněčného povrchu MeSH

• MeSH
• diabetes mellitus metabolismus   MeSH
• glukosa metabolismus   MeSH
• inzulin metabolismus   MeSH
• inzulinová rezistence MeSH
• lidé MeSH
• receptor inzulinu fyziologie   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• Názvy látek
• glukosa MeSH
• inzulin MeSH
• receptor inzulinu MeSH