• MeSH
• alopecie farmakoterapie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• melanom etiologie   MeSH
• mezoterapie * MeSH
• nádory kůže etiologie   MeSH
• skalp patologie   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• dopisy MeSH
• kazuistiky MeSH

The skin of the scalp differs from the skin on the other areas of the body because of a higher density of hair follicles and higher sebum production. These, together with the presence of hair, provide a suitable environment for superficial infections, infestations and inflammatory diseases. The good condition of the scalp has a significant impact on the patient's mental well-being and social interaction. The visibility of this part of the skin and the presence of hair itself restrict the range of possible therapeutic agents that can be used due to the complicated application and poor cosmetic outcome. That is the reason why different galenic forms are usually chosen for the scalp compared to the other sites of the skin. The article provides an overview of the most common scalp disorders, the diagnostic approach and recommendations for the treatment.

• Klíčová slova
• atopic dermatitis contact dermatitis., lice infestations, psoriasis, seborrheic dermatitis, tinea capitis,
• MeSH
• dermatózy skalpu * diagnóza   terapie   MeSH
• lidé MeSH
• psoriáza MeSH
• seboroická dermatitida * diagnóza   terapie   MeSH
• skalp patologie   MeSH
• tinea capitis MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

We report the case of a 34-year - old male with meningothelial hamartoma. The patient had a subcutaneous tumor of the scalp, clinically diagnosed as a lipoma. Histologically, the tumor consisted of mature connective tissue elements, adipose tissue, blood vessels and clusters of cuboidal or polygonal cells with scant eosinophilic or amphophilic cytoplasm and regular nuclei. Mitoses were absent. Immunohistochemically, these cells showed diffuse positivity for vimentin, epithelial membrane antigen (EMA) and progesterone receptors. Other markers examined, including α-smooth muscle actin, CD34, desmin, cytokeratin AE1/AE3, cytokeratin CAM 5.2, α-inhibin, estrogen receptors, synaptophysin, chromogranin A and S100 protein, were negative. Meningothelial hamartoma is a rare benign lesion known under many synonyms and the exact number of reported cases is difficult to establish.

• Klíčová slova
• meningothelial hamartoma - scalp - vimentin - EMA - progesterone receptor.,
• MeSH
• dospělí MeSH
• hamartom patologie   MeSH
• kožní nemoci patologie   MeSH
• lidé MeSH
• skalp patologie   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

Psoriasis is a lifelong chronic inflammatory disease affecting 2-3% of the worldwide population. Scalp psoriasis is a particular form of psoriasis characterized by lesions on the scalp, which may occur isolated or in association with other skin lesions. The aim of this study was to investigate the efficacy and safeness of an innovative treatment of scalp psoriasis, which is based on the topical application of natural products. Fifty adult subjects with scalp psoriasis (23 females, 27 males) from different European dermatological centres were included in the study. Forty-six patients with severely infiltrated psoriatic lesions were invited to use the products of Dr Michaels® (Soratinex®), according to a three-phase application, twice a day (morning and evening). The other 4 patients followed a different regimen: after a shampoo in the evening, they applied the conditioner in the night and washed it in the morning with the cleansing gel. The application time of Dr Michaels® (Soratinex®) products was 8 weeks. The treatment was evaluated at 0, 1, 2, 3, 4, 5, 6, 7, and 8 weeks. The evaluation was based on the Psoriasis Scalp Severity Index (PSSI) and on a photographic analysis at each of the medical evaluation points. At the end of the study, all patients showed an outstanding improvement. Five patients referred a transient pruritus, which regressed spontaneously without discontinuing the application. No other side effects have been described. We observe that Dr Michaels® (Soratinex®) natural product family can be considered as a valid therapeutic tool for scalp psoriasis when considering the exclusion criteria. The tested products provided an outstanding improvement of lesions in all the patients, without side effects.

• MeSH
• aplikace lokální MeSH
• biologické přípravky aplikace a dávkování   škodlivé účinky   terapeutické užití   MeSH
• dospělí MeSH
• lidé MeSH
• psoriáza farmakoterapie   patologie   terapie   MeSH
• skalp účinky léků   patologie   MeSH
• vlasové přípravky aplikace a dávkování   škodlivé účinky   terapeutické užití   MeSH
• výsledek terapie MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• klinické zkoušky MeSH
• Geografické názvy
• Evropa MeSH
• Názvy látek
• biologické přípravky MeSH
• vlasové přípravky MeSH

This article reports an unusual case of aggressive extraocular sebaceous carcinoma located on the scalp with subsequent usurpation of the bone and penetrating through the bone and meninges to the brain in a 56-year-old man affected by Muir-Torre syndrome. Microscopically, the sebaceous neoplasm was located in the middle to deep dermis without any connection to the epidermis and showed a multinodular growth with neoplastic nodules with a central comedo-type necrosis separated from each other by fibrovascular stroma. The nodules were composed of varying proportions of mature sebaceous cells and atypical basaloid cells with high degree of atypia, including high nuclear/cytoplasmic ratio, nuclear pleomorphism, macronucleoli, atypical mitoses, and necrosis. The neoplasm was totally removed. Histopathological examinations of the recurrent lesion showed identical morphological features and, in addition, signs of the tumors growing through the periosteum were noted. In the final excision specimen, both the dura mater and the brain tissue were infiltrated by the sebaceous carcinoma. The diagnosis of Muir-Torre syndrome was confirmed by molecular genetic investigation that revealed an identical germline mutation in MSH2 gene in several family members, some of whom had colorectal tumors.

• MeSH
• biopsie MeSH
• dospělí MeSH
• fatální výsledek MeSH
• fenotyp MeSH
• genetická predispozice k nemoci MeSH
• homolog 2 proteinu MutS genetika   MeSH
• imunohistochemie MeSH
• invazivní růst nádoru MeSH
• karcinom genetika   patologie   chirurgie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• magnetická rezonanční tomografie MeSH
• mozek patologie   MeSH
• mutační analýza DNA MeSH
• nádory hlavy a krku genetika   patologie   chirurgie   MeSH
• nádory mazových žláz genetika   patologie   chirurgie   MeSH
• počítačová rentgenová tomografie MeSH
• progrese nemoci MeSH
• rodokmen MeSH
• skalp patologie   chirurgie   MeSH
• Torrého-Muirův syndrom genetika   patologie   chirurgie   MeSH
• zárodečné mutace MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• Názvy látek
• homolog 2 proteinu MutS MeSH
• MSH2 protein, human MeSH Prohlížeč

The authors report a case of cutaneous angiosarcoma, composed predominantly of cytologically bland foamy cells, mimicking cutaneous xanthoma, dermal clear cell mesenchymal neoplasm, or clear cell dermatofibroma. The tumor occurred on the forehead and scalp of an 86-year-old white man with no history of radiation exposure. The tumor cells were positive for CD31, CD34, D2-40, FLI-1, and ERG, and were negative for CD68 and CD163. Conventional vasoformative areas, with atypia and mitoses that led to the correct final diagnosis, were found only in 1 of the 2 performed biopsies. Foamy cell angiosarcoma is probably one of the least common variants of cutaneous angiosarcoma and represents an important diagnostic pitfall.

• MeSH
• biopsie MeSH
• diferenciální diagnóza MeSH
• hemangiosarkom chemie   patologie   MeSH
• imunohistochemie MeSH
• kožní nemoci metabolismus   patologie   MeSH
• lidé MeSH
• nádorové biomarkery analýza   MeSH
• nádory hlavy a krku chemie   patologie   MeSH
• nádory kůže chemie   patologie   MeSH
• prediktivní hodnota testů MeSH
• senioři nad 80 let MeSH
• skalp chemie   patologie   MeSH
• xantomatóza metabolismus   patologie   MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• Názvy látek
• nádorové biomarkery MeSH

The authors report on a case of panfolliculoma with sebaceous differentiation occurring on the scalp of a 53-year-old white man and discuss the pertinent literature.

• MeSH
• biopsie MeSH
• buněčná diferenciace * MeSH
• lidé středního věku MeSH
• lidé MeSH
• mazové žlázy patologie   MeSH
• nádory hlavy a krku patologie   chirurgie   MeSH
• nádory kůže patologie   chirurgie   MeSH
• skalp patologie   chirurgie   MeSH
• vlasový folikul patologie   chirurgie   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

The presence of foreign biological substances in the human body can lead to violent immune reactions. This is the report of a very rare case involving not only the presence of a biological substance, but also a symbiotic relationship between a living plant (the common wheat grain, Triticum aestivum L.) and the human body. Black coal particles and one cereal grain were removed from the subgalea of the right parietal region of a 35-year-old man who had sustained injuries in a motor vehicle accident 16 days earlier. There were signs of germination of the grain, but no macroscopic or microscopic evidence of an inflammatory reaction. Grain germination was verified microscopically. There are various explanations for the absence of an immune reaction, but only coal-tar-induced immunosuppression can explain the observed phenomenon.

• MeSH
• cizí tělesa diagnóza   MeSH
• dopravní nehody MeSH
• dospělí MeSH
• lidé MeSH
• penetrující poranění hlavy etiologie   MeSH
• pšenice * MeSH
• semena rostlinná * MeSH
• skalp zranění   patologie   MeSH
• uhlí * MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• práce podpořená grantem MeSH
• Názvy látek
• uhlí * MeSH

Presented here are three cutaneous sebaceous tumors (one carcinoma and two sebaceomas), each demonstrating a focal glandular pattern representing apocrine differentiation. The patients, two males and one female, each clinically presented with a small solitary nodule or tumor on the scalp. None of the patients had features of Muir-Torre syndrome. Surgical removal of the lesions was performed in all cases. None of the patients developed recurrence or metastasis after surgery (follow-up ranged from 18 to 24 months). The glandular areas represented a minor but significant component of the lesions and appeared as glands of various complexity, mostly as simple round or elongated tubular structures lined by a row of cuboidal to columnar cells with eosinophilic cytoplasm and round nuclei, with or without a distinct nucleolus. Decapitation secretion was evident but not prominent. In both sebaceomas, at least a portion of the glands had a peripheral small-cell layer that appeared similar to the basal/myoepithelial cells of normal eccrine and apocrine ducts. In some glands, the basal/myoepithelial cells seemed to have undergone hyperplasia, resulting in two or more rows of cells that even formed small islands, with an overall appearance reminiscent of basal cell hyperplasia in the prostate, arising in the basal layer of the prostatic glands. The descriptive terms seboapocrine carcinoma or seboapocrine sebaceoma are proposed for such lesions. These tumors may be viewed as rare histopathological variants of sebaceous carcinoma and sebaceoma, with a second type of differentiation along the lines of the folliculosebaceous-apocrine unit.

• MeSH
• apokrinní žlázy patologie   MeSH
• buněčné jadérko ultrastruktura   MeSH
• buněčné jádro ultrastruktura   MeSH
• cytoplazma ultrastruktura   MeSH
• dospělí MeSH
• hyperplazie MeSH
• karcinom patologie   MeSH
• lidé MeSH
• myocyty hladké svaloviny patologie   MeSH
• nádory mazových žláz patologie   MeSH
• následné studie MeSH
• sebum * MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• skalp patologie   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

BACKGROUND: Cutaneous lymphomas co-expressing CD56 and CD30 are very rare. They share a clinicopathological overlap with natural killer- (NK)/T-cell lymphomas and anaplastic large-cell lymphomas (ALCLs), two entities with widely disparate clinical behavior. METHODS: We present a case of an immunocompetent 57-year-old Caucasian woman with a rapidly growing, angiodestructive and neuroinvasive primary cutaneous ALCL (PCALCL). The neoplastic population of large anaplastic CD30+ and CD56+ T cells was masked by a massive admixture of histiocytes and neutrophils. The partially ulcerated and pus-secreting tumor involved the forehead and scalp and was assessed as clinical stage IAE. RESULTS: After chemotherapy (cyclophosphamide, doxorubicin, vincristine, and prednisone), the patient achieved a complete remission. Additionally, high-dose chemotherapy with autologous peripheral blood stem-cell transplantation was administered as a consolidation of complete remission, in which she has remained for 6 years. CONCLUSIONS: This is the first CD30+ and CD56+ primary skin lymphoma to be reported on the head. The presented case carries a remarkable combination of clinicopathological features of PCALCL and NK-/T-cell lymphoma.

• MeSH
• antigen CD56 analýza   MeSH
• antigen Ki-1 analýza   MeSH
• čelo MeSH
• difúzní velkobuněčný B-lymfom farmakoterapie   imunologie   patologie   MeSH
• histiocyty cytologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• nádory hlavy a krku krevní zásobení   farmakoterapie   imunologie   patologie   MeSH
• nádory kůže krevní zásobení   farmakoterapie   imunologie   patologie   MeSH
• neutrofily cytologie   MeSH
• skalp krevní zásobení   účinky léků   inervace   patologie   MeSH
• transplantace kmenových buněk MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• práce podpořená grantem MeSH
• Názvy látek
• antigen CD56 MeSH
• antigen Ki-1 MeSH