BACKGROUND: During the coronavirus disease (COVID-19) pandemic, people volunteered for sewing hand-made face masks. However, sewing-machine operating might be associated with high ergonomic risk and a negative impact on musculoskeletal health. OBJECTIVE AND METHODS: This paper describes an ultrasonographic diagnosis of a foot ganglion - after sewing 300 face masks within two months using a foot-operated sewing machine. RESULTS: The patient significantly improved after an ultrasound-guided aspiration and corticosteroid injection. CONCLUSION: In short, we highlight the importance of ultrasound examination in the management of work (overuse)-related disorders in occupational medicine practice.

• Klíčová slova
• Coronavirus, mask, seamstress, sewing machine, ultrasound,
• MeSH
• anestetika lokální aplikace a dávkování   MeSH
• antiflogistika aplikace a dávkování   MeSH
• COVID-19 * epidemiologie   prevence a kontrola   MeSH
• cystická ganglia diagnostické zobrazování   etiologie   MeSH
• dobrovolní pracovníci * MeSH
• drenáž metody   MeSH
• intervenční ultrasonografie MeSH
• lidé středního věku MeSH
• lidé MeSH
• masky MeSH
• methylprednisolon acetát aplikace a dávkování   MeSH
• nemoci nohy (od hlezna dolů) diagnostické zobrazování   etiologie   MeSH
• nemoci z povolání diagnostické zobrazování   etiologie   MeSH
• pandemie MeSH
• poranění nohy (od hlezna dolů) komplikace   MeSH
• poranění z opakovaného přetěžování komplikace   MeSH
• SARS-CoV-2 MeSH
• textilní průmysl * MeSH
• trimekain aplikace a dávkování   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• Názvy látek
• anestetika lokální MeSH
• antiflogistika MeSH
• methylprednisolon acetát MeSH
• trimekain MeSH

Low back pain (LBP) represents an important subgroup of vertebrogenic pain with estimated prevalence around 80 %. Locally acting injectable collagen for topical application has recently extended the limited range of treatment options. The aim of the study was to evaluate the efficacy and safety of injectable collagen in patients with LBP. Patients suffering from LBP (< three months) were enrolled. They were administered either collagen 4 ml or trimecaine 1 % 4 ml in the form of subcutaneous paravertebral injections into eight pre-specified points (0.5 ml per each point) in the following schedule: two administrations in the first and second week, one in the third week. The pain intensity, Thomayer distance, Oswestry disability index, Lasseque test, quality of life, consumption of rescue medication and safety were evaluated. Exertional and rest pain, evaluated by a visual analogue scale, gradually decreased in both groups. Both treatments showed a statistically significant improvement in mobility and quality of life. The consumption of paracetamol as a rescue medication was significantly lower in patients treated with collagen than in the group treated with trimecaine (p=0.048). The analgesic efficacy of locally acting injectable collagen, as well as an analgesic sparing effect when compared to local anesthetics were demonstrated.

• MeSH
• akutní bolest farmakoterapie   MeSH
• analgetika aplikace a dávkování   MeSH
• dospělí MeSH
• Hamamelis MeSH
• jednoduchá slepá metoda MeSH
• kolagen aplikace a dávkování   MeSH
• kořeny rostlin chemie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• lumbalgie farmakoterapie   MeSH
• prospektivní studie MeSH
• rostlinné extrakty aplikace a dávkování   MeSH
• senioři MeSH
• trimekain aplikace a dávkování   MeSH
• výsledek terapie MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• randomizované kontrolované studie MeSH
• srovnávací studie MeSH
• Názvy látek
• analgetika MeSH
• kolagen MeSH
• rostlinné extrakty MeSH
• trimekain MeSH

PURPOSE OF THE STUDY: Both the range of motion and load transfer of the sacroiliac (SI) joint improve considerably after lumbar spine surgery. When, following surgery, SI joint pain develops in spite of appropriate physical therapy, injection of an anaesthetic with added corticosteroid into the SI joint is a first choice treatment. The aim of this presentation is to provide information on our experience with this therapy. MATERIAL AND METHODS: Thirty-four patients after lumbar spine fusion reported lumbalgia different form pain before surgery. In 14 (41%) of them, pain in one of the SI joints was diagnosed as the cause. This group included 12 women and two men at an average age of 56 (range, 47 to 68) years. Ten patients underwent lumbosacral fixation and four had segmental ("floating") lumbar spine fusion. All patients experienced lumbalgia at more than 3 months following surgery, at 8 months on the average (range, 4 to 12 months). None of them had SI joint pain before surgery. The diagnosis was based on specific manoeuvres on physical examination of the joint. Each patient was given an injection of 20 mg (0.5 ml) Methylprednisolone (Depo-Medrol®, Pfizer, Puurs, Belgium) and 4.5 ml 1% Mesocain (Zentiva, Praha, CR).They were inquired as to pain relief 24 h later and then at 1, 3 and 6 months after injection. Subjective feelings were assessed by a visual analogue scale (VAS). The results were analysed using descriptive statistics. RESULTS: All patients reported pain relief within 24 h of injection, but not its complete resolution. The average VAS score before and after the blockage of the SI joint was 9.1 points (8-10) and 4.8 points (2-7), respectively; this implies improvement by an average of 4.3 points (1-6), i.e., approximately by 47.3% (12.5-62.5). The duration of effects varied greatly from patient to patient. The average interval between injection and pain recurrence lasted for 5 weeks (1-28). Most frequently, relief was experienced for 2 weeks, or for 6.8 weeks with the standard deviation included. DISCUSSION Sacroiliac joint dysfunction is a very frequent cause of lumbalgia, particularly after lumbar spine surgery. Physical therapy may not always be effective. SI joint arthrodesis is indicated only in rare cases. One of the few possibilities of pain relief involves intra-articular injection of an anaesthetic with corticosteroid for booster effect. The treatment of SI joint blockage after spinal fusion has recently been dealt with in three reports in the international literature; their conclusions are in accordance with the results of this study. CONCLUSIONS: Lumbar spine stabilisation surgery may result in overloading the SI joints as the "adjacent segments". An intra-articular injection of anaesthetic can be considered a reliable method for ascertaining the SI joint as the source of a patient's problems. However, even with corticosteroid added, pain relief is not usually long-lasting.

• MeSH
• anestetika lokální aplikace a dávkování   MeSH
• bederní obratle chirurgie   MeSH
• fúze páteře * MeSH
• injekce intraartikulární MeSH
• lidé středního věku MeSH
• lidé MeSH
• lumbalgie terapie   MeSH
• měření bolesti MeSH
• methylprednisolon acetát MeSH
• methylprednisolon aplikace a dávkování   analogy a deriváty   MeSH
• sakroiliakální kloub MeSH
• senioři MeSH
• trimekain aplikace a dávkování   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• anestetika lokální MeSH
• methylprednisolon acetát MeSH
• methylprednisolon MeSH
• trimekain MeSH

This paper presents two cases of using erroneous concentrations of epinephrine during endonasal surgery. The two patients discussed were part of a larger study aimed at monitoring the absorption of epinephrine upon injection into the nasal mucosa. During this study, we observed major cardiovascular reactions in two consecutive patients--ventricular tachycardia with ventricular extrasystole and a significant rise in systolic and diastolic blood pressure and pulse rate. This state required pharmacological intervention. In hindsight, it was found that an erroneous application of ten times higher (1:10,000) concentration of epinephrine than the usual was injected. The applied solution was prepared in our institutional pharmacy and was labelled incorrectly (1:100,000 instead of 1:10,000). The authors have analysed the steps leading to the erroneous applications and recommend safety precautions for the prevention of errors in the concentration levels of epinephrine. Epinephrine injections in concentrations of 1:10,000, followed by analyses of epinephrine levels in venous blood, have not yet been described in available literature.

• MeSH
• adrenalin aplikace a dávkování   škodlivé účinky   MeSH
• anestetika lokální aplikace a dávkování   MeSH
• dospělí MeSH
• injekce MeSH
• lidé středního věku MeSH
• lidé MeSH
• medikační omyly škodlivé účinky   MeSH
• nos chirurgie   MeSH
• retrospektivní studie MeSH
• srdeční arytmie chemicky indukované   MeSH
• trimekain aplikace a dávkování   MeSH
• vazokonstriktory aplikace a dávkování   škodlivé účinky   MeSH
• vztah mezi dávkou a účinkem léčiva MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• Názvy látek
• adrenalin MeSH
• anestetika lokální MeSH
• trimekain MeSH
• vazokonstriktory MeSH

OBJECTIVES: To compare the analgesic potency and side effects of epidural combination trimecaine with morphine and bupivacaine with fentanyl in postoperative analgesia after a major urological surgery. METHODS: We randomised 150 consecutive patients. In the trimecain/morphine group (n = 75) trimecaine 50 mg with 4 mg morphine was given epidurally in 8 hour intervals. In the bupivacain/fentanyl group (n = 75) the infusion of 0.25 % bupivacaine and fentanyl 2 microg/ml was administered at an infusion rate of 8 ml/h. RESULTS: The postoperative pain scores were lower in the trimecain/morphine group, the difference was significant during the first 6 hours after surgery, there was also a trend toward higher postoperative SpO2 values in this group, the difference was significant 36 hours after surgery. The total sum of postoperative complications and side effects was significantly higher in the bupivacian/fentanyl group (p = 0.002). CONCLUSION: The combination of epidural trimecaine with morphine after a major urological surgery provides a superior analgesia with fewer side effects when compared to epidurally delivered bupivacaine with fentanyl (Tab. 2, Fig. 5, Ref. 17). Full Text (Free, PDF) www.bmj.sk.

• MeSH
• anestetika lokální * aplikace a dávkování   MeSH
• bupivakain aplikace a dávkování   MeSH
• epidurální analgezie * MeSH
• fentanyl aplikace a dávkování   MeSH
• fixní kombinace léků MeSH
• lidé středního věku MeSH
• lidé MeSH
• měření bolesti MeSH
• morfin aplikace a dávkování   MeSH
• opioidní analgetika * aplikace a dávkování   MeSH
• pooperační bolest prevence a kontrola   MeSH
• trimekain aplikace a dávkování   MeSH
• urologické chirurgické výkony * MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• randomizované kontrolované studie MeSH
• srovnávací studie MeSH
• Názvy látek
• anestetika lokální * MeSH
• bupivakain MeSH
• fentanyl MeSH
• fixní kombinace léků MeSH
• morfin MeSH
• opioidní analgetika * MeSH
• trimekain MeSH

The proportion of fucosylated glycoconjugate-containing rabbit tracheal goblet cells after intratracheal application of trimecaine was studied to evaluate its possible unfavourable effects. This lapine model is comparable with diagnostic findings in humans because airway epithelia in humans and rabbits are similar; tracheal epithelium is also practically identical to bronchial epithelium in both species. Local trimecaine anaesthesia caused a proportional decrease in percentage of the tracheal goblet cells containing both alpha(1-2)- and alpha(1-6)-, alpha(1-3)- and alpha(1-4)-fucosylated glycoconjugates as revealed 10 min postexposure using lectin histochemistry. In previous studies, only mild ultrastructural damage to the airway's epithelium was revealed, but a conspicuous decrease in sialylated glycoconjugate-containing tracheal goblet cells and the dominance of acidic sulphated glycoconjugates were observed as after-effects of the same treatment. Glycoconjugate changes can influence the inner environment of airways (e.g. viscoelastic properties of the airways' mucus and mucosal barrier functions) and thus the patient's defence barriers in airways may be weakened. Concurrently, the histochemical properties of goblet cells can be altered in bronchoscopic specimens. Since trimecaine is widely used as local anaesthesia in airways in bronchoscopy, it is necessary to heed these aforementioned effects.

• MeSH
• anestetika lokální aplikace a dávkování   škodlivé účinky   MeSH
• aplikace lokální MeSH
• fukosa metabolismus   MeSH
• glykokonjugáty analýza   metabolismus   MeSH
• histocytochemie metody   MeSH
• intratracheální anestezie škodlivé účinky   MeSH
• králíci MeSH
• lektiny metabolismus   MeSH
• pohárkové buňky chemie   účinky léků   metabolismus   MeSH
• rozvrh dávkování léků MeSH
• trachea MeSH
• trimekain aplikace a dávkování   škodlivé účinky   MeSH
• zvířata MeSH
• Check Tag
• králíci MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• anestetika lokální MeSH
• fukosa MeSH
• glykokonjugáty MeSH
• lektiny MeSH
• trimekain MeSH

In a prospective randomized study the hypothesis was tested whether infiltration of the thyroid capsule by a local anaesthetic will reduce the haemodynamic response to surgical trauma, consumption of anaesthetics and opioids during surgery and will shorten the time of arousal. A total of 64 patients indicated for planned goitre surgery were divided at random into a control group (C, n = 32) and experimental group (LA, n = 32). The preoperative medication and anesthesia did not differ in the two groups. In group C into the thyroid capsule a maximum of 40 ml saline was administered, in LA the same volume of 0.5% trimecain. A highly significant difference was found (p < 0.001) in the incidence of hypertension during surgery (21 C vs. 5 LA) and the need of further pharmacological interventions (21 vs. 8). In the control group was a higher consumption (p < 0.95) of the opioid phentanyl (167.5 +/- 111 micrograms vs. 125 +/- 93.5 micrograms), a trend of longer arousal and the need to antagonize the effect of opioid (p < 0.1). The substitution of saline by a local anaesthetic for infiltration of the thyroid capsule is a safe and simple method leading to a reduction of cardiovascular complications during surgery.

• MeSH
• anestetika lokální aplikace a dávkování   MeSH
• celková anestezie * MeSH
• injekce * MeSH
• lidé středního věku MeSH
• lidé MeSH
• peroperační komplikace prevence a kontrola   MeSH
• pooperační bolest prevence a kontrola   MeSH
• prospektivní studie MeSH
• štítná žláza * MeSH
• trimekain aplikace a dávkování   MeSH
• tyreoidektomie * MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• klinické zkoušky MeSH
• randomizované kontrolované studie MeSH
• Názvy látek
• anestetika lokální MeSH
• trimekain MeSH

• MeSH
• anestetika lokální aplikace a dávkování   farmakologie   MeSH
• aplikace lokální MeSH
• glykokonjugáty metabolismus   MeSH
• králíci MeSH
• pohárkové buňky účinky léků   metabolismus   MeSH
• respirační sliznice účinky léků   metabolismus   MeSH
• trachea účinky léků   metabolismus   MeSH
• trimekain aplikace a dávkování   farmakologie   MeSH
• zvířata MeSH
• Check Tag
• králíci MeSH
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Názvy látek
• anestetika lokální MeSH
• glykokonjugáty MeSH
• trimekain MeSH

In a prospective randomized study, the efficacy of local anaesthetic inhalation during premedication before bronchoscopic examination was evaluated. Eighty patients with chronic nonproductive cough were inhaling either nebulized anaesthetics (10 ml of 1% trimecain; 40 patients--group A) or an isotonic chlorine solution (40 patients--group B). This was followed by topical anaesthesia using spray and laryngeal syringe. Comparing the score of cough and episodes of gagging, the inhalation of local anaesthetics appeared to make the procedure slightly more comfortable for some patients. Additional anaesthesia was less frequently needed in group A than in group B (12 vs. 19 patients). However, none of the observed differences reached statistical significance. In conclusion, the inhalation of local anaesthetics at the beginning of premedication before bronchoscopy was not confirmed as a useful method that made the examination more comfortable for patients with chronic non-productive cough, but did produce a moderately beneficial effect in some of them.

• MeSH
• anestetika lokální aplikace a dávkování   MeSH
• aplikace inhalační MeSH
• bronchoskopie * MeSH
• chlorid sodný aplikace a dávkování   MeSH
• hodnotící studie jako téma MeSH
• isotonické roztoky MeSH
• lidé středního věku MeSH
• lidé MeSH
• lokální anestezie metody   MeSH
• premedikace * MeSH
• prospektivní studie MeSH
• trimekain aplikace a dávkování   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• klinické zkoušky MeSH
• randomizované kontrolované studie MeSH
• srovnávací studie MeSH
• Názvy látek
• anestetika lokální MeSH
• chlorid sodný MeSH
• isotonické roztoky MeSH
• trimekain MeSH

The authors administered to two groups (56 and 44) patients before gastroscopy analgosedation-5 mg diazepam and local anaesthesia of the throat. To the first group diazepam was administered by the i.v., to the second group by the sublingual route. The objective was to find out whether analgosedation is desirable from the patients aspect and whether the sublingual form of premedication is accepted by the patients. The authors found that 90% of the patients wish to have analgosedation and anaesthesia before the procedure. The sublingual form of administration was accepted by 89% of the patients.

• MeSH
• anestetika lokální aplikace a dávkování   MeSH
• aplikace sublinguální MeSH
• diazepam aplikace a dávkování   MeSH
• gastroskopie * MeSH
• hypnotika a sedativa aplikace a dávkování   MeSH
• injekce intravenózní MeSH
• lidé středního věku MeSH
• lidé MeSH
• trimekain aplikace a dávkování   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• srovnávací studie MeSH
• Názvy látek
• anestetika lokální MeSH
• diazepam MeSH
• hypnotika a sedativa MeSH
• trimekain MeSH