Dry eye disease (DED) is a complex multifactorial disease that affects an increasing number of patients worldwide. Close to 30% of the population has experienced dry eye (DE) symptoms and presented with some signs of the disease during their lifetime. The significant heterogeneity in the medical background of patients with DEs and in their sensitivity to symptoms renders a clear understanding of DED complicated. It has become evident over the past few years that DED results from an impairment of the ocular surface homeostasis. Hence, a holistic treatment approach that concomitantly addresses the different mechanisms that result in the destabilization of the tear film (TF) and the ocular surface would be appropriate. The goal of the present review is to compile the different types of scientific evidence (from in silico modeling to clinical trials) that help explain the mechanism of action of cationic emulsion (CE)-based eye drop technology for the treatment of both the signs and the symptoms of DED. These CE-based artificial tear (AT) eye drops designed to mimic, from a functional point of view, a healthy TF contribute to the restoration of a healthy ocular surface environment and TF that leads to a better management of DE patients. The CE-based AT eye drops help restore the ocular surface homeostasis in patients who have unstable TF or no tears.

• Klíčová slova
• artificial tear, cationic emulsion, dry eye, polar lipid, tear film lipid layer,
• MeSH
• dospělí MeSH
• emulze chemie   farmakologie   MeSH
• homeostáza MeSH
• lidé MeSH
• oči - fyziologické jevy účinky léků   MeSH
• povrchové vlastnosti účinky léků   MeSH
• slzy fyziologie   MeSH
• syndromy suchého oka farmakoterapie   MeSH
• zdraví dobrovolníci pro lékařské studie statistika a číselné údaje   MeSH
• zvlhčující oční kapky aplikace a dávkování   chemie   terapeutické užití   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• srovnávací studie MeSH
• Názvy látek
• emulze MeSH
• zvlhčující oční kapky MeSH

Some people aged 80 years and older are "memory SuperAgers" (SAs), that is, they have the episodic memory of a sexagenarian. In a sample of 208 non-demented adults, we found that 12% were SAs. A total of 101 participants completed the 4-year study; of this subsample, 10.9% were stable SAs and 61.3% stable non-SAs across all assessments. The SA phenotype is conducive to further research.

• Klíčová slova
• SuperAgers, cognitive performance stability, episodic memory, healthy aging, longitudinal study,
• MeSH
• epizodická paměť * MeSH
• kognice * MeSH
• lidé MeSH
• neuropsychologické testy statistika a číselné údaje   MeSH
• senioři nad 80 let MeSH
• stárnutí * MeSH
• zdraví dobrovolníci pro lékařské studie statistika a číselné údaje   MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH