Health-threatening consequences of carcinogen exposure are mediated via occurrence of electrophiles or reactive oxygen species. As a result, the accumulation of biomolecular damage leads to the cancer initiation, promotion or progression. Accordingly, there is an association between lifestyle factors including inappropriate diet or carcinogen formation during food processing, mainstream, second or third-hand tobacco smoke and other environmental or occupational carcinogens and malignant transformation. Nevertheless, increasing evidence supports the protective effects of naturally occurring phytochemicals against carcinogen exposure as well as carcinogenesis in general. Isolated phytochemicals or their mixtures present in the whole plant food demonstrate efficacy against malignancy induced by carcinogens widely spread in our environment. Phytochemicals also minimize the generation of carcinogenic substances during the processing of meat and meat products. Based on numerous data, selected phytochemicals or plant foods should be highly recommended to become a stable and regular part of the diet as the protectors against carcinogenesis.

• Klíčová slova
• Antioxidant, Carcinogens, Chemoprevention, Detoxification, Dietary phytochemicals, Metabolic activation, Scavenging effect,
• MeSH
• antikarcinogenní látky farmakologie   terapeutické užití   MeSH
• fytonutrienty farmakologie   terapeutické užití   MeSH
• karcinogeneze účinky léků   MeSH
• karcinogeny toxicita   MeSH
• lidé MeSH
• potraviny škodlivé účinky   MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• Názvy látek
• antikarcinogenní látky MeSH
• fytonutrienty MeSH
• karcinogeny MeSH