Health-threatening consequences of carcinogen exposure are mediated via occurrence of electrophiles or reactive oxygen species. As a result, the accumulation of biomolecular damage leads to the cancer initiation, promotion or progression. Accordingly, there is an association between lifestyle factors including inappropriate diet or carcinogen formation during food processing, mainstream, second or third-hand tobacco smoke and other environmental or occupational carcinogens and malignant transformation. Nevertheless, increasing evidence supports the protective effects of naturally occurring phytochemicals against carcinogen exposure as well as carcinogenesis in general. Isolated phytochemicals or their mixtures present in the whole plant food demonstrate efficacy against malignancy induced by carcinogens widely spread in our environment. Phytochemicals also minimize the generation of carcinogenic substances during the processing of meat and meat products. Based on numerous data, selected phytochemicals or plant foods should be highly recommended to become a stable and regular part of the diet as the protectors against carcinogenesis.

• Klíčová slova
• Antioxidant, Carcinogens, Chemoprevention, Detoxification, Dietary phytochemicals, Metabolic activation, Scavenging effect,
• MeSH
• antikarcinogenní látky farmakologie   terapeutické užití   MeSH
• fytonutrienty farmakologie   terapeutické užití   MeSH
• karcinogeneze účinky léků   MeSH
• karcinogeny toxicita   MeSH
• lidé MeSH
• potraviny škodlivé účinky   MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• Názvy látek
• antikarcinogenní látky MeSH
• fytonutrienty MeSH
• karcinogeny MeSH

Traditional supplements of selenium generally have a low degree of absorption and increased toxicity. Therefore, it is imperative to develop innovative systems as transporters of selenium compounds, which would raise the bioavailability of this element and allow its controlled release in the organism. Nanoscale selenium has attracted a great interest as a food additive especially in individuals with selenium deficiency, but also as a therapeutic agent without significant side effects in medicine. This review is focused on the incorporation of nanotechnological applications, in particular exploring the possibilities of a more effective way of administration, especially in selenium-deficient organisms. In addition, this review summarizes the survey of knowledge on selenium nanoparticles, their biological effects in the organism, advantages, absorption mechanisms, and nanotechnological applications for peroral administration.

• Klíčová slova
• anticancer effect, antimicrobial activity, biomedicine, drug delivery, nanoparticles, oxidative stress, protective effect,
• MeSH
• aplikace orální MeSH
• lékové transportní systémy metody   MeSH
• lidé MeSH
• nanočástice aplikace a dávkování   chemie   MeSH
• nanomedicína metody   MeSH
• nanotechnologie MeSH
• potravinářské přísady aplikace a dávkování   chemie   MeSH
• selen aplikace a dávkování   farmakokinetika   MeSH
• střevní sliznice účinky léků   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• Názvy látek
• potravinářské přísady MeSH
• selen MeSH