Traditional supplements of selenium generally have a low degree of absorption and increased toxicity. Therefore, it is imperative to develop innovative systems as transporters of selenium compounds, which would raise the bioavailability of this element and allow its controlled release in the organism. Nanoscale selenium has attracted a great interest as a food additive especially in individuals with selenium deficiency, but also as a therapeutic agent without significant side effects in medicine. This review is focused on the incorporation of nanotechnological applications, in particular exploring the possibilities of a more effective way of administration, especially in selenium-deficient organisms. In addition, this review summarizes the survey of knowledge on selenium nanoparticles, their biological effects in the organism, advantages, absorption mechanisms, and nanotechnological applications for peroral administration.

Central Laboratory Faculty of Pharmacy University of Veterinary and Pharmaceutical Sciences Brno Brno Czech Republic

Council for Nutritional and Environmental Medicine Rana Norway

Department of Biochemistry and Microbiology University of Chemistry and Technology Prague Czech Republic

Department of Biomedical and Environmental Analyses Faculty of Pharmacy Wroclaw Medical University Wroclaw Poland

Department of Viticulture and Enology Faculty of Horticulture Mendel University in Brno Lednice Czech Republic

School of Pharmacy and Life Sciences Robert Gordon University Aberdeen UK

State Key Laboratory of Metastable Materials Science and Technology Yanshan University Qinhuangdao People's Republic of China

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