Since the worldwide incidence of bone disorders and cartilage damage has been increasing and traditional therapy has reached its limits, nanomaterials can provide a new strategy in the regeneration of bones and cartilage. The nanoscale modifies the properties of materials, and many of the recently prepared nanocomposites can be used in tissue engineering as scaffolds for the development of biomimetic materials involved in the repair and healing of damaged tissues and organs. In addition, some nanomaterials represent a noteworthy alternative for treatment and alleviating inflammation or infections caused by microbial pathogens. On the other hand, some nanomaterials induce inflammation processes, especially by the generation of reactive oxygen species. Therefore, it is necessary to know and understand their effects in living systems and use surface modifications to prevent these negative effects. This contribution is focused on nanostructured scaffolds, providing a closer structural support approximation to native tissue architecture for cells and regulating cell proliferation, differentiation, and migration, which results in cartilage and bone healing and regeneration.

• Keywords
• bones, cartilage, healing, implants, musculoskeletal disorders, nanocomposites, nanomaterials,
• Publication type
• Journal Article MeSH
• Review MeSH

Nanoparticles can be considered as a useful tool for improving properties of poorly soluble active ingredients. Hydrochlorothiazide (Class IV of the Biopharmaceutical Classification System) was chosen as a model compound. Antisolvent precipitation-solvent evaporation and emulsion solvent evaporation methods were used for preparation of 18 samples containing hydrochlorothiazide nanoparticles. Water solutions of surfactants sodium dodecyl sulfate, Tween 80 and carboxymethyl dextran were used in mass concentrations of 1%, 3% and 5%. Acetone and dichloromethane were used as solvents of the model compound. The particle size of the prepared samples was measured by dynamic light scattering. The selected sample of hydrochlorothiazide nanoparticles stabilized with carboxymethyl dextran sodium salt with particle size 2.6 nm was characterized additionally by Fourier transform mid-infrared spectroscopy and scanning electron microscopy. It was found that the solubility of this sample was 6.5-fold higher than that of bulk hydrochlorothiazide.

• Keywords
• dynamic light scattering, hydrochlorothiazide, infrared spectroscopy, nanoparticles, scanning electron microscopy, solubility,
• MeSH
• Dynamic Light Scattering MeSH
• Hydrochlorothiazide chemical synthesis   chemistry   MeSH
• Molecular Structure MeSH
• Nanoparticles chemistry   MeSH
• Surface-Active Agents chemistry   MeSH
• Drug Compounding methods   MeSH
• Solvents chemistry   MeSH
• Solubility MeSH
• Particle Size MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Hydrochlorothiazide MeSH
• Surface-Active Agents MeSH
• Solvents MeSH