The influence of the postantibiotic effect (PAE) and the postantibiotic sub-MICs effect (PA SME) of imipenem and enoxacin on the surface hydrophobicity of S. typhimurium and S. enteritidis strains were studied by evaluating Congo red binding and the aggregation in molar solutions of ammonium sulfate (SAT). A PAE was induced by 2x and 4 x MIC of antibiotics tested for 0.5 h. Suprainhibitory concentrations of imipenem against S. typhimurium induced a short PAE (0.3-0.6 h) compared to S. enteritidis (6.0-9.7 h). Suprasubinhibitory concentrations of imipenem did not allow a regrowth of S. enteritidis. Similar results were also found for enoxacin. Evaluation of surface hydrophobic properties of the salmonellas after affecting both PAEs and PA SMEs has shown that imipenem at concentrations 4 x MIC and 4 x MIC + 0.3 x MIC partially influenced the hydrophobicity of S. typhimurium. S. enteritidis was more susceptible toward both antibiotics tested.

• MeSH
• Anti-Bacterial Agents pharmacology   MeSH
• Enoxacin pharmacology   MeSH
• Imipenem pharmacology   MeSH
• Surface Properties drug effects   MeSH
• Salmonella enteritidis drug effects   MeSH
• Salmonella typhimurium drug effects   MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Anti-Bacterial Agents MeSH
• Enoxacin MeSH
• Imipenem MeSH

The postantibiotic effect (PAE) (postantibiotic phase induced by 2x or 4x MIC) as well as the postantibiotic effect of subinhibitory concentrations (0.1x, 0.2x and 0.3x MIC) (PA SME) of netilmicin, tobramycin, ciprofloxacin and pefloxacin affected the production of the virulence factor alginate by a P. aeruginosa strain. Aminoglycosides and ciprofloxacin at a concentration of 4x MIC inhibited the alginate production more significantly than 2x MIC. Suprainhibitory concentrations of aminoglycosides were more effective than pefloxacin (2x or 4x MIC) and ciprofloxacin (2x MIC). PA SME demonstrated by the above antibiotics (with the exception of ciprofloxacin 2x MIC + 0.1x MIC) suppressed alginate production more efficiently.

• MeSH
• Alginates metabolism   MeSH
• Anti-Bacterial Agents pharmacology   MeSH
• Anti-Infective Agents pharmacology   MeSH
• Depression, Chemical MeSH
• Ciprofloxacin administration & dosage   pharmacology   MeSH
• Gentamicins administration & dosage   pharmacology   MeSH
• Cross Infection microbiology   MeSH
• Glucuronic Acid MeSH
• Hexuronic Acids MeSH
• Humans MeSH
• Microbial Sensitivity Tests MeSH
• Netilmicin administration & dosage   pharmacology   MeSH
• Pefloxacin administration & dosage   pharmacology   MeSH
• Pseudomonas Infections microbiology   MeSH
• Pseudomonas aeruginosa drug effects   isolation & purification   metabolism   pathogenicity   MeSH
• Tobramycin administration & dosage   pharmacology   MeSH
• Virulence drug effects   MeSH
• Dose-Response Relationship, Drug MeSH
• Check Tag
• Humans MeSH
• Publication type
• Journal Article MeSH
• Comparative Study MeSH
• Names of Substances
• Alginates MeSH
• Anti-Bacterial Agents MeSH
• Anti-Infective Agents MeSH
• Ciprofloxacin MeSH
• Gentamicins MeSH
• Glucuronic Acid MeSH
• Hexuronic Acids MeSH
• Netilmicin MeSH
• Pefloxacin MeSH
• Tobramycin MeSH