Migréna
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The author describes two clinical observations of migraine of the basilar artery: with infarction of the cerebellar hemisphere in a 21-year-old woman and migraine equivalents of transient homonymous hemianopsia in a 27-year-old man. The author analyzed the clinical picture and assessed seven diagnostic criteria of migraine of the basilar artery. In the prophylaxis of migrainous attacks in both instanes metipranolol-80 mg/day-proved effective.
- MeSH
- arteria basilaris * MeSH
- cerebrální infarkt komplikace MeSH
- dospělí MeSH
- lidé MeSH
- migréna etiologie MeSH
- nemoci mozečku komplikace MeSH
- vertebrobazilární insuficience komplikace MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- kazuistiky MeSH
- MeSH
- cévní bolest hlavy * diagnóza farmakoterapie MeSH
- cluster headache diagnóza farmakoterapie MeSH
- lidé MeSH
- migréna * diagnóza farmakoterapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- MeSH
- dospělí MeSH
- krční obratle patofyziologie MeSH
- krční svaly MeSH
- lidé středního věku MeSH
- lidé MeSH
- migréna etiologie patofyziologie terapie MeSH
- mladiství MeSH
- pohyb MeSH
- senioři MeSH
- spasmus patofyziologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- Klíčová slova
- CHIROPRACTIC *, MIGRAINE/therapy *,
- MeSH
- chiropraxe * MeSH
- komplementární terapie * MeSH
- krční obratle * MeSH
- lidé MeSH
- migréna terapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- MeSH
- akutní nemoc MeSH
- diferenciální diagnóza MeSH
- dospělí MeSH
- hemiplegie komplikace diagnóza genetika MeSH
- lidé MeSH
- migréna komplikace diagnóza genetika MeSH
- mladiství MeSH
- tranzitorní ischemická ataka diagnóza MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- Publikační typ
- anglický abstrakt MeSH
- časopisecké články MeSH
- Klíčová slova
- MIGRAINE *,
- MeSH
- lidé MeSH
- migréna s aurou * MeSH
- migréna * MeSH
- mozeček * MeSH
- nervová tkáň * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
BACKGROUND: Migraine and epilepsy are two paroxysmal chronic neurological disorders affecting a high number of individuals and being responsible for a high individual and socioeconomic burden. The link between these disorders has been of interest for decades and innovations concerning diagnosing and treatment enable new insights into their relationship. FINDINGS: Although appearing to be distinct at first glance, both diseases exhibit a noteworthy comorbidity, shared pathophysiological pathways, and significant overlaps in characteristics like clinical manifestation or prophylactic treatment. This review aims to explore the intricate relationship between these two conditions, shedding light on shared pathophysiological foundations, genetic interdependencies, common and distinct clinical features, clinically overlapping syndromes, and therapeutic similarities. There are several shared pathophysiological mechanisms, like CSD, the likely underlying cause of migraine aura, or neurotransmitters, mainly Glutamate and GABA, which represent important roles in triggering migraine attacks and seizures. The genetic interrelations between the two disorders can be observed by taking a closer look at the group of familial hemiplegic migraines, which are caused by mutations in genes like CACNA1A, ATP1A2, or SCN1A. The intricate relationship is further underlined by the high number of shared clinical features, which can be observed over the entire course of migraine attacks and epileptic seizures. While the variety of the clinical manifestation of an epileptic seizure is naturally higher than that of a migraine attack, a distinction can indeed be difficult in some cases, e.g. in occipital lobe epilepsy. Moreover, triggering factors like sleep deprivation or alcohol consumption play an important role in both diseases. In the period after the seizure or migraine attack, symptoms like speech difficulties, tiredness, and yawning occur. While the actual attack of the disease usually lasts for a limited time, research indicates that individuals suffering from migraine and/or epilepsy are highly affected in their daily life, especially regarding cognitive and social aspects, a burden that is even worsened using antiseizure medication. This medication allows us to reveal further connections, as certain antiepileptics are proven to have beneficial effects on the frequency and severity of migraine and have been used as a preventive drug for both diseases over many years. CONCLUSION: Migraine and epilepsy show a high number of similarities in their mechanisms and clinical presentation. A deeper understanding of the intricate relationship will positively advance patient-oriented research and clinical work.
- Klíčová slova
- Anti-seizure medication, Epilepsy, Genetics, Hemiplegic migraine, Migraine, Migralepsy, Neurotransmitters,
- MeSH
- antikonvulziva terapeutické užití MeSH
- epilepsie * etiologie genetika MeSH
- komorbidita MeSH
- lidé MeSH
- migréna s aurou * genetika MeSH
- migréna * diagnóza genetika epidemiologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- antikonvulziva MeSH
- Klíčová slova
- MIGRAINE/etiology and pathogenesis *,
- MeSH
- migréna etiologie MeSH
- Publikační typ
- časopisecké články MeSH
Migraine is a complex brain disorder explained by the interaction of genetic and environmental factors. In monogenic migraines, including familial hemiplegic migraine and migraine with aura associated with hereditary small-vessel disorders, the identified genes code for proteins expressed in neurons, glial cells, or vessels, all of which increase susceptibility to cortical spreading depression. The study of monogenic migraines has shown that the neurovascular unit plays a prominent role in migraine. Genome-wide association studies have identified numerous susceptibility variants that each result in only a small increase in overall migraine risk. The more than 180 known variants belong to several complex networks of "pro-migraine" molecular abnormalities, which are mainly neuronal or vascular. Genetics has also highlighted the importance of shared genetic factors between migraine and its major co-morbidities, including depression and high blood pressure. Further studies are still needed to map all of the susceptibility loci for migraine and then to understand how these genomic variants lead to migraine cell phenotypes.
- Klíčová slova
- Familial hemiplegic migraine, Genetics, Genome-wide association studies, Migraine, Polygenic,
- MeSH
- celogenomová asociační studie MeSH
- lidé MeSH
- migréna s aurou * MeSH
- migréna * genetika MeSH
- šířící se kortikální deprese * fyziologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
