TNF-α is a pleiotropic cytokine that is considered as a primary modifier of inflammatory and immune reaction in response to various inflammatory diseases and tumour. We investigated levels of TNF-α in 43 radicular cysts and 15 odontogenic keratocysts, obtained from patients undergoing surgery, under local anaesthesia, and after aspiration of cystic fluid from non-ruptured cysts. TNF-α is elevated in both cysts' fluid, but higher values were found in radicular cysts in comparison to keratocysts. The significantly higher concentration of TNF-α was associated with smaller radicular cysts, higher protein concentration, higher presence of inflammatory cells in peri cystic tissues, and the degree of vascularisation and cysts wall thickness (Mann-Whitney U-test, p<0.05). No correlation was found based on these parameters in odontogenic keratocyst, but all cysts have detectable concentrations of TNF-α. We here for the first time present that a difference in the concentration of TNF-α exists between these two cystic types.

• Klíčová slova
• Cyst size, Hystology, Odontogenic tumour, Radicular cysts, Surgery, TNF,
• Publikační typ
• časopisecké články MeSH

Keratocystic odontogenic tumour is relatively rare benign tumour. It is characterized by its fast aggressive growth and high risk of recurrence. Treatment is always surgical: conservative (enucleation, marsupialization) or aggressive (enucleation followed by application of Carnoy's solution, cryotherapy; peripheral ostectomy or en block resection of the jaw). Authors analysed retrospectively 22 patients who fulfilled inclusion criteria, i.e. had odontogenic keratocystic tumour of mandible, wherein antero-posterior dimension was at least 30 mm, and the tumour penetrated into the surrounding soft tissues. All patients underwent tumour enucleation, in 11 patients Carnoy's solution was given into the bone cavity after enucleation. The recurrence rate in the evaluation at least 36 months after surgery was both patient groups the same: 45.4%.

• Klíčová slova
• Carnoy’s solution, Enucleation, Keratocystic odontogenic tumour, Recurrence,
• MeSH
• chloroform terapeutické užití   MeSH
• dítě MeSH
• dospělí MeSH
• ethanol terapeutické užití   MeSH
• fixativa * MeSH
• kyselina octová terapeutické užití   MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• nádory mandibuly patologie   terapie   MeSH
• odontogenní nádory patologie   terapie   MeSH
• retrospektivní studie MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• Check Tag
• dítě MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• Carnoy's solution MeSH Prohlížeč
• chloroform MeSH
• ethanol MeSH
• fixativa * MeSH
• kyselina octová MeSH

TNF-alpha is a pleiotropic cytokine that is considered as a primary modifier of inflammatory and immune reaction in response to various inflammatory diseases and tumour. We investigated levels of TNF-alpha in 43 radicular cysts and 15 odontogenic keratocysts, obtained from patients undergoing surgery, under local anaesthesia, and after aspiration of cystic fluid from non-ruptured cysts. TNF-alpha is elevated in both cysts' fluid, but higher values were found in radicular cysts in comparison to keratocysts. The significantly higher concentration of TNF-alpha was associated with smaller radicular cysts, higher protein concentration, higher presence of inflammatory cells in peri cystic tissues, and the degree of vascularisation and cysts wall thickness (Mann-Whitney U-test, p < 0.05). No correlation was found based on these parameters in odontogenic keratocyst, but all cysts have detectable concentrations of TNF-alpha. We here for the first time present that a difference in the concentration of TNF-alpha exists between these two cystic types.

• MeSH
• cystická tekutina chemie   MeSH
• lidé MeSH
• odontogenní cysty chemie   MeSH
• radikulární cysta chemie   MeSH
• TNF-alfa analýza   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• srovnávací studie MeSH
• Názvy látek
• TNF-alfa MeSH

BACKGROUND: Odontogenic keratocysts (OKCs) now reclassified as Keratocystic odontogenic tumours (KCOTs) are a clinical entity with a characteristic microscopic picture, kinetic growth and biological behaviour. They arise from the proliferation of the epithelial dental lamina in both maxilla and mandible and occur in patients of all ages. 70-80% of keratocysts are found in the mandible commonly in the angle between the jaw and mandibular branch and maxillary region of the third molar. The cysts are long latent, often symptomless and may attain remarkable dimensions without significant deformation of the jaw bones. They are often found during routine dental X-ray examination. Compared to other types of jaw cyst, odontogenic cysts have a striking tendency to rapid growth and re-occurrence. AIMS: This review focuses on the biological characteristics, clinical behaviour and treatment of KCOTs. METHODS: The databases searched were the PubMed interface of MEDLINE and LILACS. RESULTS AND CONCLUSIONS: Ondontogenic keratinocysts are not currently a diagnostic problem. Orthopantomograms which are today ordinary tools of dental investigation enable diagnosis of clinically asymptomatic cystic lesions. The problem remains the optimal therapeutic approach to reduce the still high likelihood of postoperative recurrence. There is no complete consensus on the ideal operating procedure but cystectomy with delayed extirpation is favoured. An open question also remains the timeliness of screening for postoperative recurrences. Given that the first clinical manifestation of Nevoid Basal Cell Carcioma Syndome (NBCCS) may be lesions of this type, routine histopathological classification supplemented by analysis of immunophenotype should be done. Patients with proven sporadic and especially syndromic OKC should be long term screened. In patients with NBCC preventive X ray examination is recommended only once a year.

• MeSH
• lidé MeSH
• nádorové biomarkery analýza   MeSH
• nádory čelistí chemie   diagnóza   chirurgie   MeSH
• odontogenní cysty chemie   diagnóza   chirurgie   MeSH
• odontogenní nádory chemie   diagnóza   chirurgie   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• Názvy látek
• nádorové biomarkery MeSH

A retrospective series of 31 purely epithelial odontogenic tumours consisted of 21 ameloblastomas, 2 adenomatoid odontogenic tumours, 2 calcifying epithelial odontogenic tumours, and 6 calcifying odontogenic cysts. Modern histological classification gives an accurate picture of some of the structural and biological differences between the above types of tumour. In spite of the, their common basis does result in some of the common features so that the precise classification of the specific tumour may pose problems or give rise to terminological disputes. For practical work it will do in the group of epithelial odontogenic tumours to insist strictly on the basic condition of the absence of either proliferating mesenchyma or hard dental tissues. This requirement naturally leads to the placing of ameloblastic odontoma outside the field of purely epithelial odontongenic tumours. Judging the biological nature of epithelial odontogenic tumours according to their structure is not reliable, a fact brought out by comparisons of ameloblastoma and adenomatoid odontogenic tumours. Rather one could rely on the nature of tumour growth. An evidently carcindependent classification pattern. Suspicion of a higher degree of malignity can be expressed by description.

• MeSH
• ameloblastom patologie   MeSH
• dítě MeSH
• dospělí MeSH
• lidé MeSH
• nádory čelistí klasifikace   patologie   MeSH
• nemoci čelistí patologie   MeSH
• odontogenní cysty patologie   MeSH
• odontogenní nádory klasifikace   patologie   MeSH
• senioři MeSH
• Check Tag
• dítě MeSH
• dospělí MeSH
• lidé MeSH
• senioři MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH

A retrospective series of 9 purely mesenchymal odontogenic tumours was found to consist of 3 odontogenic fibromas, 2 myxomas, and 4 cementomas including one true benign cementoblastoma and two cementifying fibromas. One as seen to contain a conspicuously blood supplied proliferating fibrous component giving the tumour the appearance of a malignant process though no relapse was noted after the jaw resection. Periapical cement dysplasia was seen in only one case of the group; there was no case of gigantiform cementoma. The problems of mutual differential diagnosis and distinction from osteogenic tumours are subject to discussion.

• MeSH
• lidé MeSH
• nádory čelistí klasifikace   patologie   MeSH
• odontogenní nádory klasifikace   patologie   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH

In a group of 34 epitheliomesenchymal odontogenic tumours no difficulties were encountered in recognizing the seven-member group of ameloblastic fibroma (with ameloblastic odontoma and dentinoma included as variants) as distinct from group of odontomas (ameloblastic o. - 2x, complex o. - 20x, combined o. - 5x) The definition is rather a general one with the distinction of variants only sometimes possible. No ameloblastic fibrosarcoma or ameloblastic odontosarcoma were seen in the group; therefore, the question should be asked whether it is really expedient to keep independent places in the classification for so rare tumours.

• MeSH
• lidé MeSH
• nádory čelistí klasifikace   patologie   MeSH
• odontogenní nádory klasifikace   patologie   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH

• MeSH
• lidé MeSH
• odontogenní nádory klasifikace   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH

Gorlin-Goltz syndrome (GGS) is an infrequent multisystemic disease with an autosomal dominant trait, which depicted presence of numerous basal cell carcinoma in conjunction with multiorgan abnormalities. This syndrome may be diagnosed early by a dentist by routine radiographic exams in the first decade of life, since the keratocystic odontogenic tumour are usually one of the first manifestations of the syndrome. This article includes a case report of the GGS with regard to its history, incidence, etiology, features, investigations, diagnostic criteria, keratocystic odontogenic tumour and treatment modalities.

• Klíčová slova
• Bifid rib, Carnoy’s solution, Marsupialization, Nevoid basal cell carcinoma, Odontogenic keratocyst, “En-bloc” resection,
• MeSH
• bazocelulární karcinom * MeSH
• dítě MeSH
• fenotyp MeSH
• lidé MeSH
• nádory kůže * MeSH
• odontogenní nádory * MeSH
• syndrom bazocelulárního névu * diagnóza   MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

Ameloblastoma represents the most common epithelial odontogenic tumor. Because of the proximity of the maxillary tumors to the orbit and skull base, it should be managed as radically as possible. Maxillectomy, mainly via the transfacial or transoral approach, represents the most common type of surgical procedure. Drawback of these approaches is limited control of the superiomedial extent of the tumour in the paranasal area. We report the use of a combined endoscopic endonasal and transoral approach to manage maxillary plexiform ameloblastoma in a 48-year-old male patient. A combined endoscopic endonasal and transoral approach enabled the radical removal of tumour with a 1.5cm margin of radiographically intact bone with good control from both intrasinusal and intraoral aspects. Adequate visualization of the extent of the lesion (e.g. orbit, infratemporal fossa, anterior cranial base) had been achieved. Non-complicated healing was achieved. This technique of partial maxillectomy led to very good aesthetic and functional results. No recurrence had been noted during review appointments. The combination of endoscopic endonasal and transoral approach for a partial maxillectomy allows sufficient reduction of the defect, thus eliminating the necessity for reconstruction and reducing the morbidity associated with it.

• Klíčová slova
• Ameloblastoma, Endoscopic endonasal resection, Odontogenic tumour, Oroantral fistula, Partial maxillectomy, Safety margins,
• MeSH
• ameloblastom * MeSH
• estetika stomatologická MeSH
• lidé středního věku MeSH
• lidé MeSH
• lokální recidiva nádoru MeSH
• maxila MeSH
• paranazální dutiny * MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH