• Klíčová slova
• BONE DISEASES/etiology *, VASCULAR DISEASES, PERIPHERAL/complications *,
• MeSH
• kosti a kostní tkáň * MeSH
• lidé MeSH
• nemoci cév * MeSH
• nemoci kostí etiologie   MeSH
• onemocnění periferních cév komplikace   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

INTRODUCTION: Dementia is a multifactorial disease with Alzheimer's disease (AD) and vascular dementia (VaD) pathologies making the largest contributions. Yet, most genome-wide association studies (GWAS) focus on AD. METHODS: We conducted a GWAS of all-cause dementia (ACD) and examined the genetic overlap with VaD. Our dataset includes 800,597 individuals, with 46,902 and 8702 cases of ACD and VaD, respectively. Known AD loci for ACD and VaD were replicated. Bioinformatic analyses prioritized genes that are likely functionally relevant and shared with closely related traits and risk factors. RESULTS: For ACD, novel loci identified were associated with energy transport (SEMA4D), neuronal excitability (ANO3), amyloid deposition in the brain (RBFOX1), and magnetic resonance imaging markers of small vessel disease (SVD; HBEGF). Novel VaD loci were associated with hypertension, diabetes, and neuron maintenance (SPRY2, FOXA2, AJAP1, and PSMA3). DISCUSSION: Our study identified genetic risks underlying ACD, demonstrating overlap with neurodegenerative processes, vascular risk factors, and cerebral SVD. HIGHLIGHTS: We conducted the largest genome-wide association study of all-cause dementia (ACD) and vascular dementia (VaD). Known genetic variants associated with AD were replicated for ACD and VaD. Functional analyses identified novel loci for ACD and VaD. Genetic risks of ACD overlapped with neurodegeneration, vascular risk factors, and cerebral small vessel disease.

• Klíčová slova
• Alzheimer's disease, GWAS meta‐analysis, all‐cause dementia, cross‐ancestry, genome‐wide association study (GWAS), vascular dementia,
• MeSH
• Alzheimerova nemoc genetika   MeSH
• celogenomová asociační studie * MeSH
• demence genetika   MeSH
• genetická predispozice k nemoci genetika   MeSH
• lidé MeSH
• rizikové faktory MeSH
• vaskulární demence * genetika   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• metaanalýza MeSH

• Klíčová slova
• SYMPATHECTOMY *, VASCULAR DISEASES *,
• MeSH
• lidé MeSH
• nemoci cév * MeSH
• sympatektomie * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

• Klíčová slova
• REFLEX *, SKIN/blood supply *, VASCULAR DISEASES, PERIPHERAL/diagnosis *,
• MeSH
• končetiny * MeSH
• kůže krevní zásobení   MeSH
• lidé MeSH
• nemoci cév * MeSH
• onemocnění periferních cév diagnóza   MeSH
• reflex * MeSH
• vazodilatace * MeSH
• vysoká teplota * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

The term "microcirculation" refers to the terminal vascular network of the body, which includes arterioles, capillaries, venules as well as initial lymphatic vessels. Additionally, it insinuates to their unique function in thermoregulation, fluid balance, maintenance of cellular exchange, and metabolism. Disturbances of microvascular function were identified to precede macrovascular involvement in the presence of cardiovascular risk factors and is the hallmark of terminal disease stages like critical limb or acral ischemia. Nevertheless, despite its obvious significance in vascular medicine assessment of microvascular function became increasingly neglected in the clinical institutions during the last decades and seems to play a subordinary role in medical education. We therefore provide an overview over relevant and clinically practicable methods to assess microcirculation in vascular medicine with critical estimations of their pros and cons and their perspectives in the future.

• Klíčová slova
• Capillary microscopy, O2C, indocianine green fluorescence angiography, laser speckled contrast analyzer, tcpO2,
• MeSH
• arterioly MeSH
• kapiláry MeSH
• lidé MeSH
• mikrocirkulace MeSH
• nemoci cév * MeSH
• venuly MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

• Klíčová slova
• VASCULAR DISEASES, PERIPHERAL *,
• MeSH
• lidé MeSH
• nemoci cév * MeSH
• onemocnění periferních cév * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

In connection with the increasing importance of the endothelium in understanding the pathogenesis of vascular diseases, new types of mediators originating in the endothelium are described, such as EDRF and endothelin. The method of endothelial cell cultivation has contributed to their detection. Besides such analytical methods, a more global in vivo aspect of endothelial function is dealt with by the method of counting circulating endothelial cell carcasses in blood applicable also clinically. The increase of endothelaemia goes hand in hand with both the tendency to thrombosis and increased permeability. Similarly, the main atherosclerotic risk factors, smoking, hypertension and hypercholesterolaemia could be effective by producing an endothelial perturbation as indicated by increased endothelaemia.

• MeSH
• arterioskleróza etiologie   MeSH
• cévní endotel fyziologie   MeSH
• kapilární permeabilita MeSH
• lidé MeSH
• modely kardiovaskulární MeSH
• trombocyty fyziologie   MeSH
• trombóza etiologie   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH

• Klíčová slova
• ARTERIOSCLEROSIS OBLITERANS *, ELECTROMYOGRAPHY *, RAYNAUD'S DISEASE *, THROMBOANGIITIS OBLITERANS *,
• MeSH
• arteriosclerosis obliterans * MeSH
• elektromyografie * MeSH
• lidé MeSH
• nemoci cév * MeSH
• Raynaudova nemoc * MeSH
• tromboangitis obliterans * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

BACKGROUND: The aim of this study was to evaluate the clinical experience with 310 robot assisted vascular procedures. The da Vinci system has been used by a variety of disciplines for laparoscopic procedures but the use of robots in vascular surgery is still relatively uncommon. METHODS: From November 2005 to May 2014, 310 robot assisted vascular operations were performed. Two hundred and twenty four patients were prospectively evaluated for occlusive disease, 61 patients for abdominal aortic aneurysm, four for a common iliac artery aneurysm, four for a splenic artery aneurysm, one for a internal mammary artery aneurysm, and after the unsuccessful endovascular treatment five for hybrid procedures, two patients for median arcuate ligament release and nine for endoleak II treatment post EVAR. Among these patients, 224 underwent robotic occlusive disease treatment (Group I), 65 robotic aorto-iliac aneurysm surgery (Group II) and 21 other robotic procedures (Group III). RESULTS: A total of 298 cases (96.1%) were successfully completed robotically. In 10 patients (3.2%) conversion was necessary. The 30 day mortality was 0.3%, and two (0.6%) late prosthetic infections were seen. Targeted Group I and Group II patients were compared. Robotic ilio-femoral bypass, aorto-femoral bypass, or aorto-iliac thrombo-endarterectomy with prosthetic patch (Group I) required an operative time of 194 (range, 127-315) minutes and robotic aorto-iliac aneurysm surgery (Group II), 253 (range, 185-360) minutes. The mean aortic cross clamping time was 37 minutes in Group I and 93 minutes in Group II. The mean blood loss was more significant in Group II (1,210 mL) than in Group I (320 mL). CONCLUSION: From a practical point of view, the greatest advantage of the robot assisted procedure has been the speed and relative simplicity of construction of the vascular anastomosis. This experience with robot assisted laparoscopic surgery has demonstrated the feasibility of this technique in different areas of vascular surgery.

• Klíčová slova
• Aortic and non-aortic surgery, Laparoscopic vascular surgery, Robot assisted vascular surgery,
• MeSH
• aneurysma břišní aorty chirurgie   MeSH
• aneurysma chirurgie   MeSH
• arteria lienalis chirurgie   MeSH
• arteriální okluzní nemoci chirurgie   MeSH
• dospělí MeSH
• endoleak etiologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• mamární tepny chirurgie   MeSH
• nemoci aorty chirurgie   MeSH
• nemoci cév chirurgie   MeSH
• retrospektivní studie MeSH
• roboticky asistované výkony metody   MeSH
• senioři MeSH
• výkony cévní chirurgie přístrojové vybavení   metody   MeSH
• výsledek terapie MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• audiovizuální média MeSH
• časopisecké články MeSH

• Klíčová slova
• BRAIN/diseases *, NECROSIS *, VASCULAR DISEASES, PERIPHERAL/complications *,
• MeSH
• mozek * MeSH
• nekróza * MeSH
• nemoci cév * MeSH
• nemoci mozku * MeSH
• onemocnění periferních cév komplikace   MeSH
• Publikační typ
• časopisecké články MeSH