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Antiviral acyclic nucleoside phosphonates structure activity studies
Holý A.
Language English Country Netherlands
Document type Review
- MeSH
- Antiviral Agents pharmacology chemistry MeSH
- DNA Viruses drug effects MeSH
- Financing, Organized MeSH
- DNA Virus Infections drug therapy virology MeSH
- Humans MeSH
- Nucleosides pharmacology chemistry MeSH
- Organophosphonates pharmacology chemistry MeSH
- Structure-Activity Relationship MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
This review concerns acyclic nucleoside phosphonates (ANP) and describes the concept of the design of isopolar and isosteric nucleotide analogues resistant towards degradation by enzymes in vivo. It describes the development of research which led to the discovery of several structurally related potent antivirals and ultimately resulted in the development of drugs directed against HIV, HBV and DNA-virus infections in general, namely adefovir, cidofovir and tenofovir. In addition to these "classical compounds" the review describes the present development in the field of ANP, the "open-ring ANP" and discusses the present achievements, concept of prodrug design and application.
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