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Feasible predictions of bone remodelling using modelling techniques
Klika V., Maršík F.
Language English Country Czech Republic
- MeSH
- Biomechanical Phenomena physiology MeSH
- Estradiol isolation & purification classification blood MeSH
- Financing, Organized MeSH
- Bone Density physiology MeSH
- Humans MeSH
- RANK Ligand isolation & purification classification blood MeSH
- Mechanical Phenomena MeSH
- Nitric Oxide classification MeSH
- Parathyroid Hormone isolation & purification classification blood MeSH
- Bone Remodeling physiology MeSH
- Statistics as Topic MeSH
- Models, Theoretical MeSH
- Thermodynamics MeSH
- Check Tag
- Humans MeSH
This manuscript gives an overview of our team effort to formulate a bone remodelling model that would comprise both crucial control mechanisms in this process: RANKLRANK- OPG pathway and (dynamic) loading. Main focus is aimed at how model of interdisciplinary problem can be tracked down and how its results and analysis may provide valuable information hopefully not only to mathematicians but to clinicians as well. Modelling is always a theoretical work that is always built upon some simplifications and assumptions which lead to intrinsic limitations of the model that need to be found. Here we provide feasible results that can be obtained through our approach and offer them to discussion.
Lit.: 61
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- $a Institute of Thermomechanics v.v.i., Academy of Sciences of Czech Republic, Prague
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- $a Lit.: 61
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- $a This manuscript gives an overview of our team effort to formulate a bone remodelling model that would comprise both crucial control mechanisms in this process: RANKLRANK- OPG pathway and (dynamic) loading. Main focus is aimed at how model of interdisciplinary problem can be tracked down and how its results and analysis may provide valuable information hopefully not only to mathematicians but to clinicians as well. Modelling is always a theoretical work that is always built upon some simplifications and assumptions which lead to intrinsic limitations of the model that need to be found. Here we provide feasible results that can be obtained through our approach and offer them to discussion.
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