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Role of γ-h2ax in dna-damage response and its possible clinical applications
Eva Novotna , Ales Tichy, Karolina Foltanova, Jirina Vavrova
Jazyk angličtina Země Česko
Typ dokumentu přehledy
Digitální knihovna NLK
Zdroj
NLK
ROAD: Directory of Open Access Scholarly Resources
od 2011
- MeSH
- biologické markery MeSH
- chromatin genetika metabolismus MeSH
- DNA vazebné proteiny genetika metabolismus MeSH
- DNA účinky záření MeSH
- dvouřetězcové zlomy DNA účinky záření MeSH
- financování organizované MeSH
- fosforylace MeSH
- fosfoserin metabolismus MeSH
- histony genetika metabolismus MeSH
- ionizující záření MeSH
- jaderné proteiny genetika metabolismus MeSH
- lidé MeSH
- nádory diagnóza MeSH
- oprava DNA MeSH
- tyrosin metabolismus MeSH
- vazba proteinů MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
The integrity of the human genome is constantly threatened by exogenous or endogenous genotoxic agents that cause DNA damage. The ionizing radiation (IR)-induced DNA double-strand breaks (DSBs) are considered as the most deleterious forms of DNA damage which could lead to genomic instability and to cancer development, if left unrepaired. The DNA damage response (DDR) is comprised of a network of proteins that cooperate to regulate cell cycle progression and repair of DNA lesions. Our understanding of molecular basis of repair processes and of functions of repair proteins, as well as understanding of chromatin modifications may provide new possibilities in improvement of cancer management. Phosphorylation of histone variant H2AX at serine 139 (γ-H2AX) and formation of γ-H2AX repair foci seems to be the most sensitive DNA damage marker in the chromatin flanking the free DNA double-stranded ends in DSBs. Monitoring of γ-H2AX levels can serve for early indication of cancer development, as biomarker of cancer therapy efficiency or as a biodosimetric marker of radiation exposure.
Department of Medical Biochemistry Faculty of Medicine in Hradec Králové Charles University Prague
Department of Radiobiology Faculty of Military Health Sciences University of Defence Hradec Králové
Citace poskytuje Crossref.org
Literatura
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