• Je něco špatně v tomto záznamu ?

Mutational analysis (c.402C>G) of the FOXL2 gene and immunohistochemical expression of the FOXL2 protein in testicular adult type granulosa cell tumors and incompletely differentiated sex cord stromal tumors

O. Hes, T. Vaněček, F. Petersson, P. Grossmann, M. Hora, DM. Perez Montiel, P. Steiner, M. Dvořák, M. Michal,

. 2011 ; 19 (4) : 347-51.

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc12028442

BACKGROUND: Recently a somatic point mutation in the FOXL2 gene has been characterized in ovarian adult type of granulosa cell tumor (ATGCT) (94.6%), thecomas (12.5%), but not in juvenile type of ovarian granulosa cell tumor, other ovarian sex cord tumors and ovarian surface epithelial neoplasms. Whether this mutation is present in testicular ATGCT or incompletely differentiated sex cord stromal tumor (ISCST) is not known. DESIGN: Four ATGCTs, 4 ISCST were immunohistochemically investigated with anti-FOXL2 and 3 ovarian ATGCTs were used as positive control. RESULTS: Weak-to-moderate immunoreactivity was found in all tested testicular and ovarian tumors. PCR and direct sequencing were used for detection of c.402C>G of the FOXL2 gene. No mutation was found in any of the testicular ATGCTs or ISCSTs whereas all ovarian tumors showed the c.402C>G point mutation of the FOXL2 gene. CONCLUSIONS: On the basis of this small series of these rare testicular neoplasms, it seems that the c.402C>G mutation of the FOXL2 gene frequently found in adult type of ovarian GCT does not play any significant role in the development of ATGCT and ISCST.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc12028442
003      
CZ-PrNML
005      
20121206112709.0
007      
ta
008      
120817s2011 xxu f 000 0#eng||
009      
AR
024    7_
$a 10.1097/pai.0b013e3182039ef2 $2 doi
035    __
$a (PubMed)21293260
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Hes, Ondřej, $d 1968- $7 jn20001103502 $u Department of Special Diagnostics, Charles University and University Hospital Plzen, Plzen, Czech Republic. hes@medima.cz
245    10
$a Mutational analysis (c.402C>G) of the FOXL2 gene and immunohistochemical expression of the FOXL2 protein in testicular adult type granulosa cell tumors and incompletely differentiated sex cord stromal tumors / $c O. Hes, T. Vaněček, F. Petersson, P. Grossmann, M. Hora, DM. Perez Montiel, P. Steiner, M. Dvořák, M. Michal,
520    9_
$a BACKGROUND: Recently a somatic point mutation in the FOXL2 gene has been characterized in ovarian adult type of granulosa cell tumor (ATGCT) (94.6%), thecomas (12.5%), but not in juvenile type of ovarian granulosa cell tumor, other ovarian sex cord tumors and ovarian surface epithelial neoplasms. Whether this mutation is present in testicular ATGCT or incompletely differentiated sex cord stromal tumor (ISCST) is not known. DESIGN: Four ATGCTs, 4 ISCST were immunohistochemically investigated with anti-FOXL2 and 3 ovarian ATGCTs were used as positive control. RESULTS: Weak-to-moderate immunoreactivity was found in all tested testicular and ovarian tumors. PCR and direct sequencing were used for detection of c.402C>G of the FOXL2 gene. No mutation was found in any of the testicular ATGCTs or ISCSTs whereas all ovarian tumors showed the c.402C>G point mutation of the FOXL2 gene. CONCLUSIONS: On the basis of this small series of these rare testicular neoplasms, it seems that the c.402C>G mutation of the FOXL2 gene frequently found in adult type of ovarian GCT does not play any significant role in the development of ATGCT and ISCST.
650    _2
$a mladiství $7 D000293
650    _2
$a dospělí $7 D000328
650    _2
$a senioři $7 D000368
650    _2
$a buněčná diferenciace $7 D002454
650    _2
$a dítě $7 D002648
650    _2
$a předškolní dítě $7 D002675
650    _2
$a mutační analýza DNA $7 D004252
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a forkhead transkripční faktory $x genetika $x metabolismus $7 D051858
650    _2
$a genetické asociační studie $7 D056726
650    _2
$a nádor z folikulárních buněk $x diagnóza $x genetika $x patologie $7 D006106
650    _2
$a lidé $7 D006801
650    _2
$a imunohistochemie $7 D007150
650    _2
$a kojenec $7 D007223
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a nádory vaječníků $x diagnóza $x genetika $x patologie $7 D010051
650    _2
$a bodová mutace $x genetika $7 D017354
650    _2
$a gonadální stromální nádory $x diagnóza $x genetika $x patologie $7 D018312
650    _2
$a testikulární nádory $x diagnóza $x genetika $x patologie $7 D013736
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Vaněček, Tomáš $7 xx0044814
700    1_
$a Petersson, Fredrik
700    1_
$a Grossmann, Petr
700    1_
$a Hora, Milan
700    1_
$a Perez Montiel, Delia M
700    1_
$a Steiner, Petr
700    1_
$a Dvořák, Miroslav
700    1_
$a Michal, Michal, $d 1959- $7 jn20001103501
773    0_
$w MED00005735 $t Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry $x 1533-4058 $g Roč. 19, č. 4 (2011), s. 347-51
856    41
$u https://pubmed.ncbi.nlm.nih.gov/21293260 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y m
990    __
$a 20120817 $b ABA008
991    __
$a 20121206112742 $b ABA008
999    __
$a ok $b bmc $g 950484 $s 785788
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2011 $b 19 $c 4 $d 347-51 $i 1533-4058 $m Applied immunohistochemistry & molecular morphology $n Appl. immunohistochem. mol. morphol. (Print) $x MED00005735
LZP    __
$a Pubmed-20120817/11/04

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace