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Long-term protection against hepatitis B after newborn vaccination : 20-year follow-up
L Roznovsky, I Orsagova, A Kloudova, J Tvrdik, L Kabieszova, I Lochman, J Mrazek, L Hozakova, A Zjevikova, L Pliskova
Jazyk angličtina Země Německo
Grantová podpora
NR9275
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Část
Zdroj
NLK
ProQuest Central
od 1997-01-01 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2000-02-01 do Před 1 rokem
Nursing & Allied Health Database (ProQuest)
od 1997-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 1997-01-01 do Před 1 rokem
Public Health Database (ProQuest)
od 1997-01-01 do Před 1 rokem
- MeSH
- čas MeSH
- dítě MeSH
- hepatitida - antigeny imunologie krev MeSH
- hepatitida B - protilátky imunologie krev MeSH
- hepatitida B imunologie prevence a kontrola virologie MeSH
- kojenec MeSH
- lidé MeSH
- mladiství MeSH
- následné studie MeSH
- novorozenec MeSH
- očkovací schéma MeSH
- předškolní dítě MeSH
- těhotenství MeSH
- vakcína proti hepatitidě B * aplikace a dávkování imunologie MeSH
- vakcinace MeSH
- vertikální přenos infekce * prevence a kontrola MeSH
- virus hepatitidy B * imunologie MeSH
- Check Tag
- dítě MeSH
- kojenec MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- novorozenec MeSH
- předškolní dítě MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
BACKGROUND: Hepatitis B vaccination in children born to hepatitis B surface antigen (HBsAg)-positive mothers considerably decreases the risk of vertical transmission. However, whether this protection against carriage of hepatitis B virus is maintained into early adulthood is as yet unknown. PATIENTS AND METHODS: A combined passive-active immunization programme for newborns of HBsAg-positive mothers was initiated in the north-eastern part of the Czech Republic in 1988. The number of immunized newborns had reached 665 newborns by the end of 2006. All mothers of immunized infants were HBsAg-positive during pregnancy, and 34 (5%) were also hepatitis B e antigen (HBeAg)-positive. The immunization programme consists of providing newborns with protection at birth with hepatitis B immunoglobulin, followed by three 10-ug doses of plasma-derived or, since 1990, recombinant vaccine administered at 0, 1 and 6months of life. Only 29 children of HBeAg-positive mothers received vaccine at 0, 1 and 2months of life. Blood samples were obtained after immunization, at 2years of age, and biennially thereafter. Samples were tested for HBsAg and hepatitis B surface and core antibodies (anti-HBs, anti-HBc). RESULTS: The immunization schedules were completed in 640 children. A protective anti-HBs level after immunization was proven in 574 of 620 children (93%). Persistence of protective anti-HBs antibodies was detected in 70, 40 and 25% of children at 5, 10 and 15years of age. Vertical transmission with chronic HBsAg carrier status was detected in two infants. Anti-HBc seroconversion was proven in ten children from 3 to 15years of age. Natural boosting with an anti-HBs increase was detected in 38 children (twice in one child). CONCLUSION: Our results show that combined active-passive immunization of newborns against hepatitis B provides persistent protection up to adolescence despite a frequent waning of anti-HBs antibodies, suggesting there is no need for booster vaccination during adolescence.
Department of Infectious Diseases University Hospital Ostrava Czech Republic
Department of Informatics and Computers University of Ostrava Czech Republic
Citace poskytuje Crossref.org
Obsahuje tabulku
Bibliografie atd.Literatura
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