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Neuroinflammation and complexes of 17β-hydroxysteroid dehydrogenase type 10--amyloid β in Alzheimer's disease
Zuzana Krištofiková, Daniela Řípová, Aleš Bartoš, Markéta Bocková, Kateřina Hegnerová, Jan Řičný, Linda Čechová, Monika Vrajová, Jiří Homola,
Jazyk angličtina Země Spojené arabské emiráty
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
NT11225
MZ0
CEP - Centrální evidence projektů
- MeSH
- 17-hydroxysteroidní dehydrogenasy MeSH
- Alzheimerova nemoc komplikace MeSH
- amyloidní beta-protein MeSH
- ELISA MeSH
- lidé MeSH
- nemoci centrálního nervového systému komplikace MeSH
- nemoci cév komplikace MeSH
- nemoci periferního nervového systému komplikace MeSH
- neparametrická statistika MeSH
- peptidové fragmenty MeSH
- povrchová plasmonová rezonance MeSH
- senioři MeSH
- zánět komplikace MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Multifunctional mitochondrial enzyme 17β-hydroxysteroid dehydrogenase type 10 plays a role in the development of Alzheimer's disease. However, changes in its expression in the brain or cerebrospinal fluid are not fully specific for this type of dementia. Our previous study revealed that complexes of the enzyme and amyloid β in cerebrospinal fluid could serve as a more specific biomarker of Alzheimer's disease than either the enzyme or amyloid β individually when compared to autoimmune multiple sclerosis. In this study, enzyme-linked immunosorbent assay and the surface plasmon resonance biosensor method were used to analyse cerebrospinal fluid of patients with various neuroinflammatory diseases. Significant differences in the levels of the total enzyme, complexes, amyloid β 1-42 and total τ/phospho-τ were found in Alzheimer's disease patients while differences in complexes, total amyloid β and amyloid β 1- 42 were observed in patients with neuroinflammatory diseases (except for multiple sclerosis) when compared to non-neuroinflammatory controls. The interactions of the enzyme with amyloid β appeared to depend strongly on neuroinflammation-sensitive amyloid β. Our data demonstrated that oligomerisation/aggregation of intracellular amyloid β peptides was important in Alzheimer's disease while extracellular amyloid β could play a role in neuroinflammatory diseases. Phospho-τ is currently the best biomarker of Alzheimer's disease.
Institute of Photonics and Electronics ASCS Prague Czech Republic
Citace poskytuje Crossref.org
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