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Impaired pre-mRNA processing and altered architecture of 3' untranslated regions contribute to the development of human disorders
E. Michalova, B. Vojtesek, R. Hrstka,
Language English Country Switzerland
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
NLK
Free Medical Journals
from 2000
Freely Accessible Science Journals
from 2000
PubMed Central
from 2007
Europe PubMed Central
from 2007
ProQuest Central
from 2000-03-01
Open Access Digital Library
from 2000-01-01
Open Access Digital Library
from 2007-01-01
Health & Medicine (ProQuest)
from 2000-03-01
ROAD: Directory of Open Access Scholarly Resources
from 2000
PubMed
23896598
DOI
10.3390/ijms140815681
Knihovny.cz E-resources
- MeSH
- 3' Untranslated Regions MeSH
- Chorea genetics metabolism pathology MeSH
- Heredodegenerative Disorders, Nervous System genetics metabolism pathology MeSH
- Dementia genetics metabolism pathology MeSH
- Trinucleotide Repeat Expansion MeSH
- Cognition Disorders genetics metabolism pathology MeSH
- Nucleic Acid Conformation MeSH
- Humans MeSH
- Myotonic Dystrophy genetics metabolism pathology MeSH
- Neoplasms genetics metabolism pathology MeSH
- RNA Precursors genetics metabolism MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
The biological fate of each mRNA and consequently, the protein to be synthesised, is highly dependent on the nature of the 3' untranslated region. Despite its non-coding character, the 3' UTR may affect the final mRNA stability, the localisation, the export from the nucleus and the translation efficiency. The conserved regulatory sequences within 3' UTRs and the specific elements binding to them enable gene expression control at the posttranscriptional level and all these processes reflect the actual state of the cell including proliferation, differentiation, cellular stress or tumourigenesis. Through this article, we briefly outline how the alterations in the establishment and final architecture of 3' UTRs may contribute to the development of various disorders in humans.
References provided by Crossref.org
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