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Caspase-7 participates in differentiation of cells forming dental hard tissues
E. Matalova, H. Lesot, E. Svandova, T. Vanden Berghe, PT. Sharpe, C. Healy, P. Vandenabeele, AS. Tucker,
Language English Country Japan
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
Free Medical Journals
from 1969 to 1 year ago
Medline Complete (EBSCOhost)
from 1998-08-01 to 1 year ago
Wiley Free Content
from 1997 to 1 year ago
PubMed
23713787
DOI
10.1111/dgd.12066
Knihovny.cz E-resources
- MeSH
- Ameloblasts cytology enzymology metabolism MeSH
- Cell Differentiation * MeSH
- Time Factors MeSH
- Immunohistochemistry MeSH
- Caspase 7 genetics metabolism MeSH
- Mice, Inbred C57BL MeSH
- Mice, Knockout MeSH
- Mice MeSH
- Odontoblasts cytology enzymology metabolism MeSH
- Odontogenesis MeSH
- Cell Proliferation MeSH
- X-Ray Microtomography MeSH
- Incisor embryology growth & development metabolism MeSH
- Dental Enamel embryology growth & development metabolism MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Apoptosis during tooth development appears dependent on the apoptotic executioner caspase-3, but not caspase-7. Instead, activated caspase-7 has been found in differentiated odontoblasts and ameloblasts, where it does not correlate with apoptosis. To further investigate these findings, the mouse incisor was used as a model. Analysis of caspase-7-deficient mice revealed a significant thinner layer of hard tissue in the adult incisor. Micro computed tomography scan confirmed this decrease in mineralized tissues. These data strongly suggest that caspase-7 might be directly involved in functional cell differentiation and regulation of the mineralization of dental matrices.
References provided by Crossref.org
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