The study examines production of proinflammatory IL-1b, IL-8, γ -IFN and anti-inflammatory (IL-4) cytokines in newborns from mothers with healthy pregnancy and with the intrauterine infections. Under supervision there were 55 children, newborn from the mothers with herpes virus infections: from them 21 in the early neonatal period, 19 - in the late neonatal period. The control group included 15 healthy children newborn from healthy mothers with favourable course of pregnancy. The analysis has shown that γ-IFN level, in the early neonatal period in children with intrauterine infection, was in the average 7.0±0.73 pg/ml or 3.6 times lower (P<0.05) than control. In the late neonatal period production of γ-IFN increased up to 11.2±0.74 pg/ml (Р<0.05), but without reaching of control meanings. The reduced production of γ-IFN results, apparently, to long recurrent disease. The performed examinations have shown that the development of pathological process at herpes virus infection is accompanied by significant balance disturbance of proinflammatory and anti-inflammatory cytokines during all neonatal period. The revealed cytokine profile changes in the newborns in the short age periods and their severity degree show important pathogenic role of immune mechanisms in the development and progressing of herpes virus infections.

Institute of Immunology Academy of Sciences Tashkent Pediatric Medical Institute Uzbekistan

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