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Glia and Neural Stem and Progenitor Cells of the Healthy and Ischemic Brain: The Workplace for the Wnt Signaling Pathway
T. Knotek, L. Janeckova, J. Kriska, V. Korinek, M. Anderova
Language English Country Switzerland
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
NLK
Free Medical Journals
from 2010
PubMed Central
from 2010
Europe PubMed Central
from 2010
ProQuest Central
from 2010-03-01
Open Access Digital Library
from 2010-01-01
Open Access Digital Library
from 2010-01-01
ROAD: Directory of Open Access Scholarly Resources
from 2010
PubMed
32708801
DOI
10.3390/genes11070804
Knihovny.cz E-resources
- MeSH
- Cell Differentiation genetics MeSH
- Molecular Targeted Therapy methods trends MeSH
- Adult MeSH
- Brain Ischemia genetics metabolism pathology physiopathology MeSH
- Humans MeSH
- Brain cytology pathology physiology MeSH
- Neural Stem Cells pathology physiology MeSH
- Neurogenesis physiology MeSH
- Neuroglia pathology physiology MeSH
- Wnt Signaling Pathway genetics physiology MeSH
- Ischemic Attack, Transient genetics metabolism pathology therapy MeSH
- Health MeSH
- Animals MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
Wnt signaling plays an important role in the self-renewal, fate-commitment and survival of the neural stem/progenitor cells (NS/PCs) of the adult central nervous system (CNS). Ischemic stroke impairs the proper functioning of the CNS and, therefore, active Wnt signaling may prevent, ameliorate, or even reverse the negative effects of ischemic brain injury. In this review, we provide the current knowledge of Wnt signaling in the adult CNS, its status in diverse cell types, and the Wnt pathway's impact on the properties of NS/PCs and glial cells in the context of ischemic injury. Finally, we summarize promising strategies that might be considered for stroke therapy, and we outline possible future directions of the field.
2nd Faculty of Medicine Charles University 84 5 Uvalu 150 06 Prague Czech Republic
Institute of Molecular Genetics Czech Academy of Sciences 1083 Videnska 142 20 Prague Czech Republic
References provided by Crossref.org
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