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Genetic aspects of endothelium dysfunction in Uzbek hypertensive patients
Gulnoza Khamidullaeva, Amayak Kevorkov, Marietta Eliseyeva
Medical and Health Science Journal.
2010 ;
4 (4) :
30-36.
Jazyk angličtina Země Česko
Perzistentní odkaz
https://www.medvik.cz/link/bmc14048383
- Klíčová slova
- bradykinin B2-receptor, beta2-adrenoreceptor,
- MeSH
- alely MeSH
- analýza polymorfismu délky amplifikovaných restrikčních fragmentů MeSH
- angiotensin konvertující enzym genetika MeSH
- angiotensinogen genetika MeSH
- cévní endotel * patofyziologie MeSH
- cytochrom P450 CYP11B2 genetika MeSH
- dospělí MeSH
- genotyp MeSH
- heterotrimerní G-proteiny genetika MeSH
- hypertenze * MeSH
- lidé středního věku MeSH
- lidé MeSH
- multivariační analýza MeSH
- polymorfismus genetický * MeSH
- receptor angiotensinu typ 1 genetika MeSH
- synthasa oxidu dusnatého, typ III genetika MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Geografické názvy
- Uzbekistán MeSH
The objective of the study was to evaluate the prevalence of ACE/ID, AGT/M235T, AT1R/A1166C, CYP11B2/C344T, B2ВKR/ 9-9, ecNOS/4a4b, GNB3/C825T, and ARB2/Gln27Glu gene polymorphisms and their association with endothelium dysfunction (ED) in Uzbek hypertensive patients. The study found an association between ED and AGT M235T gene polymorphism. Genetic models disclosed that the T-allele, MT-, and TT-genotypes of the AGT gene were associated with an increased risk of ED. However, multivariate logistic regression analysis confirmed the negative association between the MM genotype of the AGT gene and positive association between IMT and ED. An association between essential hypertension (EH) in Uzbek males with ACE/ID and GNB3/C825T gene polymorphisms has been demonstrated. There is an
Bibliografie atd.
Literatura
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