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Length of occlusion predicts recanalization and outcome after intravenous thrombolysis in middle cerebral artery stroke
V. Rohan, J. Baxa, R. Tupy, L. Cerna, P. Sevcik, M. Friesl, J. Polivka, J. Polivka, J. Ferda,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
Free Medical Journals
od 1970 do Před 1 rokem
Open Access Digital Library
od 1970-01-01
Open Access Digital Library
od 1970-01-01
- MeSH
- čtyřrozměrná počítačová tomografie přístrojové vybavení metody MeSH
- dospělí MeSH
- fibrinolytika aplikace a dávkování farmakologie MeSH
- infarkt arteria cerebri media * farmakoterapie patologie radiografie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mozková angiografie MeSH
- mozkový krevní oběh účinky léků fyziologie MeSH
- prediktivní hodnota testů MeSH
- retrospektivní studie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- tkáňový aktivátor plazminogenu aplikace a dávkování farmakologie MeSH
- trombolytická terapie metody MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
BACKGROUND AND PURPOSE: The length of large vessel occlusion is considered a major factor for therapy in patients with ischemic stroke. We used 4D-CT angiography evaluation of middle cerebral artery occlusion in prediction of recanalization and favorable clinical outcome and after intravenous thrombolysis (IV-tPA). METHODS: In 80 patients treated with IV-tPA for acute complete middle cerebral artery/M1 occlusion determined using CT angiography and temporal maximum intensity projection, calculated from 4D-CT angiography, the length of middle cerebral artery proximal stump, occlusion in M1 or M1 and M2 segment were measured. Univariate and multivariate analyses were performed to define independent predictors of successful recanalization after 24 hours and favorable outcome after 3 months. RESULTS: The length of occlusion was measureable in all patients using temporal maximum intensity projection. Recanalization thrombolysis in myocardial infarction 2 to 3 was achieved in 37 individuals (46%). The extension to M2 segment as a category (odds ratio, 4.58; 95% confidence interval, 1.39-15.05; P=0.012) and the length of M1 segment occlusion (odds ratio, 0.82; 95% confidence interval, 0.73-0.92; P=0.0007) with an optimal cutoff value of 12 mm (sensitivity 0.67; specificity 0.71) were significant independent predictors of recanalization. Favorable outcome (modified Rankin scale 0-2) was achieved in 25 patients (31%), baseline National Institutes of Health Stroke Scale (odds ratio, 0.82; 95% confidence interval, 0.72-0.93; P=0.003) and the length of occlusion M1 in segment (odds ratio, 0.79; 95% confidence interval, 0.69-0.91; P=0.0008) with an optimal cutoff value of 11 mm (sensitivity 0.74; specificity 0.76) were significant independent predictors of favorable outcome. CONCLUSIONS: The length of middle cerebral artery occlusion is an independent predictor of successful IV-tPA treatment.
Citace poskytuje Crossref.org
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- $a Rohan, Vladimir $u From the Department of Neurology (V.R., L.C., P.S., J.P.) and Department of Imaging Methods (J.B., R.T., J.F.), Faculty of Medicine in Plzen, Charles University in Prague and Faculty Hospital Plzen, Plzen, Czech Republic; Department of Mathematics, Faculty of Applied Sciences, University of West Bohemia Plzen, Plzen, Czech Republic (M.F.); and Department of Histology and Embryology and Biomedical Centre, Faculty of Medicine in Plzen, Charles University in Prague, Plzen, Czech Republic (J.P.). rohan@fnplzen.cz.
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- $a Length of occlusion predicts recanalization and outcome after intravenous thrombolysis in middle cerebral artery stroke / $c V. Rohan, J. Baxa, R. Tupy, L. Cerna, P. Sevcik, M. Friesl, J. Polivka, J. Polivka, J. Ferda,
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- $a BACKGROUND AND PURPOSE: The length of large vessel occlusion is considered a major factor for therapy in patients with ischemic stroke. We used 4D-CT angiography evaluation of middle cerebral artery occlusion in prediction of recanalization and favorable clinical outcome and after intravenous thrombolysis (IV-tPA). METHODS: In 80 patients treated with IV-tPA for acute complete middle cerebral artery/M1 occlusion determined using CT angiography and temporal maximum intensity projection, calculated from 4D-CT angiography, the length of middle cerebral artery proximal stump, occlusion in M1 or M1 and M2 segment were measured. Univariate and multivariate analyses were performed to define independent predictors of successful recanalization after 24 hours and favorable outcome after 3 months. RESULTS: The length of occlusion was measureable in all patients using temporal maximum intensity projection. Recanalization thrombolysis in myocardial infarction 2 to 3 was achieved in 37 individuals (46%). The extension to M2 segment as a category (odds ratio, 4.58; 95% confidence interval, 1.39-15.05; P=0.012) and the length of M1 segment occlusion (odds ratio, 0.82; 95% confidence interval, 0.73-0.92; P=0.0007) with an optimal cutoff value of 12 mm (sensitivity 0.67; specificity 0.71) were significant independent predictors of recanalization. Favorable outcome (modified Rankin scale 0-2) was achieved in 25 patients (31%), baseline National Institutes of Health Stroke Scale (odds ratio, 0.82; 95% confidence interval, 0.72-0.93; P=0.003) and the length of occlusion M1 in segment (odds ratio, 0.79; 95% confidence interval, 0.69-0.91; P=0.0008) with an optimal cutoff value of 11 mm (sensitivity 0.74; specificity 0.76) were significant independent predictors of favorable outcome. CONCLUSIONS: The length of middle cerebral artery occlusion is an independent predictor of successful IV-tPA treatment.
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- $a Baxa, Jan $u From the Department of Neurology (V.R., L.C., P.S., J.P.) and Department of Imaging Methods (J.B., R.T., J.F.), Faculty of Medicine in Plzen, Charles University in Prague and Faculty Hospital Plzen, Plzen, Czech Republic; Department of Mathematics, Faculty of Applied Sciences, University of West Bohemia Plzen, Plzen, Czech Republic (M.F.); and Department of Histology and Embryology and Biomedical Centre, Faculty of Medicine in Plzen, Charles University in Prague, Plzen, Czech Republic (J.P.).
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- $a Tupy, Radek $u From the Department of Neurology (V.R., L.C., P.S., J.P.) and Department of Imaging Methods (J.B., R.T., J.F.), Faculty of Medicine in Plzen, Charles University in Prague and Faculty Hospital Plzen, Plzen, Czech Republic; Department of Mathematics, Faculty of Applied Sciences, University of West Bohemia Plzen, Plzen, Czech Republic (M.F.); and Department of Histology and Embryology and Biomedical Centre, Faculty of Medicine in Plzen, Charles University in Prague, Plzen, Czech Republic (J.P.).
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- $a Cerna, Lenka $u From the Department of Neurology (V.R., L.C., P.S., J.P.) and Department of Imaging Methods (J.B., R.T., J.F.), Faculty of Medicine in Plzen, Charles University in Prague and Faculty Hospital Plzen, Plzen, Czech Republic; Department of Mathematics, Faculty of Applied Sciences, University of West Bohemia Plzen, Plzen, Czech Republic (M.F.); and Department of Histology and Embryology and Biomedical Centre, Faculty of Medicine in Plzen, Charles University in Prague, Plzen, Czech Republic (J.P.).
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- $a Sevcik, Petr $u From the Department of Neurology (V.R., L.C., P.S., J.P.) and Department of Imaging Methods (J.B., R.T., J.F.), Faculty of Medicine in Plzen, Charles University in Prague and Faculty Hospital Plzen, Plzen, Czech Republic; Department of Mathematics, Faculty of Applied Sciences, University of West Bohemia Plzen, Plzen, Czech Republic (M.F.); and Department of Histology and Embryology and Biomedical Centre, Faculty of Medicine in Plzen, Charles University in Prague, Plzen, Czech Republic (J.P.).
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- $a Friesl, Michal $u From the Department of Neurology (V.R., L.C., P.S., J.P.) and Department of Imaging Methods (J.B., R.T., J.F.), Faculty of Medicine in Plzen, Charles University in Prague and Faculty Hospital Plzen, Plzen, Czech Republic; Department of Mathematics, Faculty of Applied Sciences, University of West Bohemia Plzen, Plzen, Czech Republic (M.F.); and Department of Histology and Embryology and Biomedical Centre, Faculty of Medicine in Plzen, Charles University in Prague, Plzen, Czech Republic (J.P.).
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- $a Polivka, Jiri $u From the Department of Neurology (V.R., L.C., P.S., J.P.) and Department of Imaging Methods (J.B., R.T., J.F.), Faculty of Medicine in Plzen, Charles University in Prague and Faculty Hospital Plzen, Plzen, Czech Republic; Department of Mathematics, Faculty of Applied Sciences, University of West Bohemia Plzen, Plzen, Czech Republic (M.F.); and Department of Histology and Embryology and Biomedical Centre, Faculty of Medicine in Plzen, Charles University in Prague, Plzen, Czech Republic (J.P.).
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- $a Ferda, Jiri $u From the Department of Neurology (V.R., L.C., P.S., J.P.) and Department of Imaging Methods (J.B., R.T., J.F.), Faculty of Medicine in Plzen, Charles University in Prague and Faculty Hospital Plzen, Plzen, Czech Republic; Department of Mathematics, Faculty of Applied Sciences, University of West Bohemia Plzen, Plzen, Czech Republic (M.F.); and Department of Histology and Embryology and Biomedical Centre, Faculty of Medicine in Plzen, Charles University in Prague, Plzen, Czech Republic (J.P.).
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