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The utility of three-dimensional optical projection tomography in nerve injection injury imaging
E. Cvetko, M. Čapek, M. Damjanovska, MA. Reina, I. Eržen, T. Stopar-Pintarič,
Language English Country England, Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
25827062
DOI
10.1111/anae.13066
Knihovny.cz E-resources
- MeSH
- Anesthetics, Local administration & dosage MeSH
- Fluorescence MeSH
- Nerve Block adverse effects MeSH
- Lingual Nerve radiography MeSH
- Median Nerve injuries radiography MeSH
- Tomography, Optical * MeSH
- Lingual Nerve Injuries etiology radiography MeSH
- Swine MeSH
- Imaging, Three-Dimensional * MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
The examination of nerve microarchitecture has hitherto been limited solely to two-dimensional imaging techniques. The objective of this study was to evaluate the ability of optical projection tomography to discern the nerve microarchitecture and injection injury in three dimensions. Five piglets were studied, whose median and lingual nerves were unilaterally injected post mortem with preset volumes of local anaesthetic, excised and subsequently made transparent with benzyl alcohol benzyl benzoate. Images were captured in three dimensions. The same contralateral nerves were used as controls. Using optical projection tomography, we observed differences between the internal organisation of the median and the lingual nerves, which potentially explain the variations in their susceptibility to injury. This was demonstrated in three dimensions as a disruption to the fascicles in the lingual nerve, and their displacement in the median nerve. This new technology offers potential for studying nerve microarchitecture topography and its tolerance to injection injury.
Institute of Anatomy Faculty of Medicine University of Ljubljana Ljubljana Slovenia
Institute of Physiology of the Czech Academy of Sciences Prague Czech Republic
References provided by Crossref.org
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