• Je něco špatně v tomto záznamu ?

Anemia in adenine-induced chronic renal failure and the influence of treatment with gum acacia thereon

B. H. Ali, M. Al Za'abi, A. Ramkumar, J. Yasin, A. Nemmar

. 2014 ; 63 (3) : 351-358. [pub] 20140224

Jazyk angličtina Země Česko

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc15033329

Anemia frequently complicates chronic kidney disease (CKD). We investigated here the effect of adenine-induced CKD in rats on erythrocyte count (EC), hematocrit (PCV) and hemoglobin (Hb) concentration, as well as on the activity of L-gamma-glutamyl transferase (GGT) and the concentrations of iron (Fe), transferrin (Tf), ferritin (F), total iron binding capacity (TIBC) / unsaturated iron binding capacity (UIBC) and hepcidin (Hp) in serum and erythropoietin (Epo) in renal tissue. Renal damage was assessed histopathologically, and also by measuring the serum concentrations of the uremic toxin indoxyl sulfate (IS), creatinine, and urea, and by creatinine clearance. We also assessed the influence of concomitant treatment with gum acacia (GA) on the above analytes. Adenine feeding induced CKD, accompanied by significant decreases (P<0.05) in EC, PCV, and Hb, and in the serum concentrations of Fe, Tf, TIBC, UIBC and Epo. It also increased Hp and F levels. GA significantly ameliorated these changes in rats with CKD. A general improvement in the renal status of rats with CKD after GA is shown due to its anti-inflammatory and anti-oxidant actions, and reduction of the uremic toxin IS, which is known to suppress Epo production, and this may be a reason for its ameliorative actions on the indices of anemia studied.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc15033329
003      
CZ-PrNML
005      
20151030140808.0
007      
ta
008      
151016s2014 xr d f 000 0|eng||
009      
AR
024    7_
$a 10.33549/physiolres.932685 $2 doi
035    __
$a (PubMed)24564605
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Ali, B. H. $u Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, Al Khod, Oman $7 gn_A_00004176
245    10
$a Anemia in adenine-induced chronic renal failure and the influence of treatment with gum acacia thereon / $c B. H. Ali, M. Al Za'abi, A. Ramkumar, J. Yasin, A. Nemmar
520    9_
$a Anemia frequently complicates chronic kidney disease (CKD). We investigated here the effect of adenine-induced CKD in rats on erythrocyte count (EC), hematocrit (PCV) and hemoglobin (Hb) concentration, as well as on the activity of L-gamma-glutamyl transferase (GGT) and the concentrations of iron (Fe), transferrin (Tf), ferritin (F), total iron binding capacity (TIBC) / unsaturated iron binding capacity (UIBC) and hepcidin (Hp) in serum and erythropoietin (Epo) in renal tissue. Renal damage was assessed histopathologically, and also by measuring the serum concentrations of the uremic toxin indoxyl sulfate (IS), creatinine, and urea, and by creatinine clearance. We also assessed the influence of concomitant treatment with gum acacia (GA) on the above analytes. Adenine feeding induced CKD, accompanied by significant decreases (P<0.05) in EC, PCV, and Hb, and in the serum concentrations of Fe, Tf, TIBC, UIBC and Epo. It also increased Hp and F levels. GA significantly ameliorated these changes in rats with CKD. A general improvement in the renal status of rats with CKD after GA is shown due to its anti-inflammatory and anti-oxidant actions, and reduction of the uremic toxin IS, which is known to suppress Epo production, and this may be a reason for its ameliorative actions on the indices of anemia studied.
650    _2
$a adenin $7 D000225
650    _2
$a anemie $x farmakoterapie $7 D000740
650    _2
$a zvířata $7 D000818
650    _2
$a arabská guma $x farmakologie $x terapeutické užití $7 D006170
650    _2
$a chronické selhání ledvin $x krev $x chemicky indukované $x komplikace $7 D007676
650    _2
$a mužské pohlaví $7 D008297
650    12
$a fytoterapie $7 D008517
650    _2
$a náhodné rozdělení $7 D011897
650    _2
$a potkani Wistar $7 D017208
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Al Za'abi, M. $u Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, Al Khod, Oman $7 gn_A_00003198
700    1_
$a Ramkumar, A. $u Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, Al Khod, Oman
700    1_
$a Yasin, J. $u Department of Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain,United Arab Emirates
700    1_
$a Nemmar, A. $u Department of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain,United Arab Emirates
773    0_
$w MED00003824 $t Physiological research Academia Scientiarum Bohemoslovaca $x 1802-9973 $g Roč. 63, č. 3 (2014), s. 351-358
856    41
$u http://www.biomed.cas.cz/physiolres/ $y domovská stránka časopisu
910    __
$a ABA008 $b A 4120 $c 266 $y 4 $z 0
990    __
$a 20151016 $b ABA008
991    __
$a 20151027073507 $b ABA008
999    __
$a ok $b bmc $g 1095668 $s 916460
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2014 $b 63 $c 3 $d 351-358 $e 20140224 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
LZP    __
$b NLK118 $a Pubmed-20151016

Najít záznam

Citační ukazatele

Možnosti archivace