-
Something wrong with this record ?
Azoospermia with variable testicular histology after 7 months of treatment with a deslorelin implant in toms
R. Novotny, R. Vitasek, A. Bartoskova, P. Cizek, P. Prinosilova, K. Novakova,
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Contraception methods veterinary MeSH
- Azoospermia chemically induced veterinary MeSH
- Gonadotropin-Releasing Hormone agonists MeSH
- Drug Implants MeSH
- Cats * MeSH
- Contraceptive Agents, Male administration & dosage MeSH
- Sperm Motility drug effects MeSH
- Spermatogenesis drug effects MeSH
- Testis anatomy & histology MeSH
- Triptorelin Pamoate administration & dosage analogs & derivatives MeSH
- Animals MeSH
- Check Tag
- Cats * MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
The main aim of the study was to assess whether the longer use of a GnRH-agonist implant (deslorelin 4.7 mg, Suprelorin) in toms would lead to the suppression of spermatogenesis comparable with histologic appearance in juvenile animals as was previously described in dogs. The other aims were to monitor the progression of the testes size decrease and development of azoospermia 5 to 7 months after treatment with a GnRH-agonist implant. In animals, 5, 6, and 7 months after GnRH-agonist implant insertion, variable histological appearance of germinal epithelium was found, when tubules with elongating spermatids, round spermatids, spermatocytes, and spermatogonia as the most developed germinal cells were found in each group of toms. In all male cats, 5, 6, and 7 months after implant insertion, testosterone concentrations and testes size significantly differed between the first and the last visit. All animals, except one tom castrated 5 months after implant insertion, developed complete azoospermia. However, in this tom, all spermatozoa were immotile. Treatment with the subcutaneous GnRH-agonist implant was well tolerated, and no treatment-related adverse effects were noted. These results reported the efficacy of 4.7-mg deslorelin implant (Suprelorin) during its 7 months of use. The complete azoospermia confirms its contraceptive effect. However, the histologic evaluation revealed a great individual variability in the degree of spermatogenic suppression. The question as to whether spermatogenesis in toms can be suppressed in all males to the level of spermatogonia/primary spermatocytes after prolonged exposure to deslorelin has yet to be answered.
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc16000350
- 003
- CZ-PrNML
- 005
- 20160127122320.0
- 007
- ta
- 008
- 160108s2015 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.theriogenology.2014.12.026 $2 doi
- 035 __
- $a (PubMed)25617987
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Novotny, R $u Department of Reproduction, Clinic of Dog and Cat Diseases, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic. Electronic address: novotnyr@vfu.cz.
- 245 10
- $a Azoospermia with variable testicular histology after 7 months of treatment with a deslorelin implant in toms / $c R. Novotny, R. Vitasek, A. Bartoskova, P. Cizek, P. Prinosilova, K. Novakova,
- 520 9_
- $a The main aim of the study was to assess whether the longer use of a GnRH-agonist implant (deslorelin 4.7 mg, Suprelorin) in toms would lead to the suppression of spermatogenesis comparable with histologic appearance in juvenile animals as was previously described in dogs. The other aims were to monitor the progression of the testes size decrease and development of azoospermia 5 to 7 months after treatment with a GnRH-agonist implant. In animals, 5, 6, and 7 months after GnRH-agonist implant insertion, variable histological appearance of germinal epithelium was found, when tubules with elongating spermatids, round spermatids, spermatocytes, and spermatogonia as the most developed germinal cells were found in each group of toms. In all male cats, 5, 6, and 7 months after implant insertion, testosterone concentrations and testes size significantly differed between the first and the last visit. All animals, except one tom castrated 5 months after implant insertion, developed complete azoospermia. However, in this tom, all spermatozoa were immotile. Treatment with the subcutaneous GnRH-agonist implant was well tolerated, and no treatment-related adverse effects were noted. These results reported the efficacy of 4.7-mg deslorelin implant (Suprelorin) during its 7 months of use. The complete azoospermia confirms its contraceptive effect. However, the histologic evaluation revealed a great individual variability in the degree of spermatogenic suppression. The question as to whether spermatogenesis in toms can be suppressed in all males to the level of spermatogonia/primary spermatocytes after prolonged exposure to deslorelin has yet to be answered.
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a azoospermie $x chemicky indukované $x veterinární $7 D053713
- 650 12
- $a kočky $7 D002415
- 650 _2
- $a antikoncepce $x metody $x veterinární $7 D003267
- 650 _2
- $a kontraceptiva mužská $x aplikace a dávkování $7 D003272
- 650 _2
- $a implantované léky $7 D004343
- 650 _2
- $a hormon uvolňující gonadotropiny $x agonisté $7 D007987
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a motilita spermií $x účinky léků $7 D013081
- 650 _2
- $a spermatogeneze $x účinky léků $7 D013091
- 650 _2
- $a testis $x anatomie a histologie $7 D013737
- 650 _2
- $a triptorelin-pamoát $x aplikace a dávkování $x analogy a deriváty $7 D017329
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Vitasek, R $u Department of Reproduction, Clinic of Dog and Cat Diseases, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic.
- 700 1_
- $a Bartoskova, A $u Department of Reproduction, Clinic of Dog and Cat Diseases, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic.
- 700 1_
- $a Cizek, P $u Department of Anatomy, Histology and Embryology, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic.
- 700 1_
- $a Prinosilova, P $u Department of Genetics and Reproduction, Veterinary Research Institute, Brno, Czech Republic.
- 700 1_
- $a Novakova, K $u Department of Reproduction, Clinic of Dog and Cat Diseases, University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic.
- 773 0_
- $w MED00004512 $t Theriogenology $x 1879-3231 $g Roč. 83, č. 7 (2015), s. 1188-93
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/25617987 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20160108 $b ABA008
- 991 __
- $a 20160127122444 $b ABA008
- 999 __
- $a ok $b bmc $g 1102631 $s 924556
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2015 $b 83 $c 7 $d 1188-93 $e 20141231 $i 1879-3231 $m Theriogenology $n Theriogenology $x MED00004512
- LZP __
- $a Pubmed-20160108
